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Effect of Synthetic Bone Mineral to Osseointegration in a Rat Model of Osteoporosis

Research Project

Project/Area Number 15H06645
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNihon University

Principal Investigator

WATANABE Takehiro  日本大学, 松戸歯学部, 助手(専任扱) (80759986)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsサプリメント / 骨粗鬆症 / インプラント / 歯学
Outline of Final Research Achievements

The purpose of the present study was to confirm whether intake of Synthetic bone mineral (SBM) developed for osteoporosis supplement, affect peri-implant bone formation in an ovariectomized rat.
Pull-out strength and BMD for the Diet with SBM group were significantly greater than those without SBM group.Fluorescence microscopy imaging of the Diet with SBM group demonstrated more green fluorescence (indicating bone formation) than that of the Diet without SBM group. BV/TV, BS/BV, TbTh and Vtr in the Diet with SBM group were significantly greater than those in the Diet without SBM group. This study demonstrated that SBM could be effective in accelerating peri-implant bone formation and improve the trabecular structure in an ovariectomized rat.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (6 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis2016

    • Author(s)
      Takahashi, T. Watanabe, T. Nakada, H. Tanimoto, Y. Kimoto, S. Mijares, D. Q. Zhang, Y. Kawai, Y.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 60 Issue: 2 Pages: 131-137

    • DOI

      10.1016/j.jpor.2015.12.006

    • NAID

      130005172131

    • ISSN
      1883-1958, 1883-9207
    • Year and Date
      2016-04-25
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Improved Bone Micro Architecture Healing Time after Implant Surgery in an Ovariectomized Rat2016

    • Author(s)
      Takahashi, T. Watanabe, T. Nakada, H. T, H. Sato, Y. Tanimoto, T. Sakae, S. Kimoto, Mijares, D. Q. Zhang, Y. Kawai, Y.
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 25 Issue: 3 Pages: 257-262

    • DOI

      10.2485/jhtb.25.257

    • NAID

      130005163161

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Study on Synthetic Bone Mineral to Shorten Implant Treatment in a Rat Model of Osteoporosis2017

    • Author(s)
      Takehiro Watanabe Takahiro Takahashi, Hiroshi Nakada, Hiroki sato2, Daisuke Isaji, Yasuhiro Tanimoto, Suguru Kimoto, and Yasuhiko Kawai
    • Organizer
      IADR/AADR/CADR GENERAL SESSION & EXHIBITION; SAN FRANCISCO, CALIF.
    • Place of Presentation
      Moscone Center(San francisco・America)
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] サプリメントの摂取が 骨粗鬆症モデルラットの インプラント体周囲骨の骨形成に与える影響2016

    • Author(s)
      髙橋卓裕、渡辺丈紘、佐藤博紀、中田浩史、飯島守雄、 伊藤誠康、岡田裕之、河相安彦
    • Organizer
      第46回日本口腔インプラント学会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨粗鬆症ラットにおけるインプラント体周囲骨の微小構造に対するサプリメントの影響2016

    • Author(s)
      渡辺丈紘、高橋卓裕、佐藤博紀、谷本安浩、中田浩史、木本統、北村彩、佐藤佳奈美、飯島守雄、河相安彦
    • Organizer
      公益社団法人日本補綴歯科学会第125回学術大会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨粗鬆症モデルラットにおいて SBM の経口摂取が骨形成作用に与える影響2016

    • Author(s)
      石渡幸志、渡辺丈紘、 高橋卓裕、 佐藤博紀、谷本安浩、中田浩史、梅木賢人、木本統、河相安彦
    • Organizer
      公益社団法人日本補綴歯科学会第125回学術大会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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