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The improvement effect of periodontal disease by cacao bean extract

Research Project

Project/Area Number 15H06697
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Epidemiology and preventive medicine
Research InstitutionKanagawa Dental College

Principal Investigator

Sasaki Haruka  神奈川歯科大学, 大学院歯学研究科, 特別研究員 (50757200)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsカカオ抽出物 / カカオ豆抽出物 / 歯周病 / 抗菌効果 / 抗酸化
Outline of Final Research Achievements

It is reported that cocoa bean extract has the inhibition effects of the collagenase produced by Porphyromonas gingivalis (P. gingivalis) such as the periodontal pathogenic bacteria. Therefore, we assessed the improvement effect of periodontal disease using cocoa bean extract (CBP and PW-VE-R) against P. gingivalis. The antimicrobial activity of cocoa bean against P. gingivalis and biofilm was recognized by using CBP and PW-VE-R. In addition, the scavenging activities against the reactive oxygen species such superoxide and hydroxyl radical wer indicated with cocoa bean extract. These results suggested that cocoa bean extract might have the improvement effect on periodontal tissue destruction.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Protective effects of (6R)-5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva2016

    • Author(s)
      Tanaka Y, Toyama T, Wada-Takahashi S, Sasaki H, Miyamoto C, Maehata Y, Yoshino F, Yoshida A, Takahashi S-S, Watanabe K, Lee M-C, Todoki K, Hamada N
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 1 Pages: 69-75

    • DOI

      10.3164/jcbn.15-69

    • NAID

      130005116629

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] バイオフィルム除去に効果的な抗菌療法とは?2015

    • Author(s)
      佐々木悠
    • Journal Title

      日本歯科評論

      Volume: 75 Pages: 143-146

    • Related Report
      2015 Annual Research Report
  • [Presentation] Transmission of Porphyromonas gulae between dogs and their owners2016

    • Author(s)
      佐々木悠
    • Organizer
      日本細菌学会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 口腔用組成物2017

    • Inventor(s)
      佐々木悠
    • Industrial Property Rights Holder
      佐々木悠
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-14
    • Related Report
      2016 Annual Research Report

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Published: 2015-08-26   Modified: 2018-12-17  

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