| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
It is reported that cocoa bean extract has the inhibition effects of the collagenase produced by Porphyromonas gingivalis (P. gingivalis) such as the periodontal pathogenic bacteria. Therefore, we assessed the improvement effect of periodontal disease using cocoa bean extract (CBP and PW-VE-R) against P. gingivalis. The antimicrobial activity of cocoa bean against P. gingivalis and biofilm was recognized by using CBP and PW-VE-R. In addition, the scavenging activities against the reactive oxygen species such superoxide and hydroxyl radical wer indicated with cocoa bean extract. These results suggested that cocoa bean extract might have the improvement effect on periodontal tissue destruction.
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