| Project/Area Number |
15H06712
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔扁平上皮癌 / 血液型抗原 / Lewis y / 糖タンパク質 / フコシルトランスフェラーゼ / EGFR / チロシンリン酸化 / 糖脂質 |
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| Outline of Final Research Achievements |
It was demonstrated that blood group antigen Lewis y modification on EGF receptor (R) suppresses phosphorylated EGFR, resulting in the attenuation of malignant properties in oral squamous cell carcinomas. As the mechanisms, it was shown that Lewis y modification on EGFR blocks EGF binding sites on it, resulting in the reduction of dimerization of EGFR and the suppression of phosphorylation of EGFR.
Attenuation of expression of Lewis y in cancer cells leads to the detachment of cells under EGF stimulation and the suppression of adhesion to extracellular matrix. Collectively, this study suggests the reduction of expression of Lewis y makes up environments that cancer cells are tend to move to different areas, resulting in the promotion of malignant properties.
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