The Functions of Glucose-Responsive ATP-sensitive K (KATP) Channels in Peripheral Nervous Systems

• Project/Area Number: 15H06720
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Aichi Medical University
• Principal Investigator: Himeno Tatsuhito 愛知医科大学, 医学部, 助教 (60753762)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病性多発神経障害 / 糖尿病性合併症 / 糖尿病神経障害 / グルコース応答性カリウムチャネル / KATP channel / グルコース応答性 / 末梢神経系

Outline of Final Research Achievements

We aimed to clarify the pathology of diabetic polyneuropathy. Based on the finding that glucose responsive KATP channel (KATP), a target of insulin secretagogue sulfonyl urea (SU) drug, controls nerve excitability according to energy metabolic state, we investigated the physiological role of KATP in the peripheral nervous system.
As a result, it was revealed that SUs and KATP openers can exert neuroprotective action or conversely nerve injury action in dorsal root ganglion neuron cultures. In the KATP knockout mice, it was revealed that the peripheral nervous system declined at an earlier stage than the wild type mice with aging. Thus, it was suggested that KATP plays an important role in maintaining the peripheral nervous system.

Research Products

• [Journal Article] Novel mechanism for counter-regulatory responses to hypoglycemia. (2017)
  • Author(s): Tatsuhito Himeno, Jiro Nakamura.
  • Journal Title: Journal of Diabetes Investigations Volume: 8 Issue: 1 Pages: 29-31
  • DOI: 10.1111/jdi.12527
  • Peer Reviewed / Open Access
• [Presentation] 末梢神経系におけるglucose応答性KATP channelの生理的機能に関する検討 (2017)
  • Author(s): 下田博美、姫野龍仁、茂木幹雄、浅野紗恵子、速水智英、浅野栄水、山田祐一郎、三浦絵美梨、近藤正樹、恒川新、加藤義郎、神谷英紀、中村二郎
  • Organizer: 第31回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2017-02-10
• [Presentation] The Functions of Glucose-Responsive ATP-sensitive Potassium Channels in The Peripheral Nervous System of Mice (2016)
  • Author(s): TATSUHITO HIMENO, HIDEKI KAMIYA, YUSUKE SEINO, KEIKO NARUSE, TOMOHIDE HAYAMI, MIKIO MOTEGI, SAEKO NODA, TETSUJI OKAWA, MASAKI KONDO, SHIN TSUNEKAWA, SUSUMU SEINO, JIRO NAKAMURA,
  • Organizer: the American Diabetes Association’s 76th Scientific Sessions
  • Place of Presentation: New Orleans
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] The Functions of Glucose-Responsive ATP-sensitive Potassium Channels in The Peripheral Nervous System of Mice (2016)
  • Author(s): Tatsuhito Himeno, Hideki Kamiya, Yusuke Seino, Keiko Naruse, Tomohide Hayami, Mikio Motegi, Saeko Noda, Tetsuji Okawa, Masaki Kondo, Shin Tsunekawa, Susumu Seino, Jiro Nakamura
  • Organizer: the American Diabetes Association's 76th Scientific Sessions
  • Place of Presentation: New Orleans
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Remarks] 愛知医科大学糖尿病内科
  • URL: http://www.aichi-med-u.ac.jp/su06/su0607/su060703/06.html