| Project/Area Number |
15H06727
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Gタンパク共役型脂質受容体 / 炎症性腸疾患 / GPR35 / GPR40 / 正常消化管上皮細胞 / GLP-2 |
|---|
| Outline of Final Research Achievements |
GPR35 activation promoted wound repair by colonic epithelial cells, and ameliorated onset of DSS-induced colitis via coupling of Gi protein, decrease in cAMP, upregulation of fibronectin and integrin α5 expression, and ERK phosphorylation in colonic epithelial cells. GPR40 stimulation was effective in both onset and mucosal healing of DSS-induced colitis, mediated by increase in GLP-2 production. Our results indicates that lipid G protein-coupled receptors such as GPR35 and GPR40 may be novel candidates for therapeutic target in inflammatory bowel disease.
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