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Energy and ROS metabolism in radioresistant brain tumor stem cells

Research Project

Project/Area Number 15H06804
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurosurgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

Sun Lue  産業医科大学, 産業生態科学研究所, 訪問研究員 (40757704)

Research Collaborator YAMADA Shokei  
Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脳腫瘍 / がん幹細胞 / 酸化ストレス / 解糖系 / ミトコンドリア呼吸 / 放射線抵抗性 / レドックスバランス / ESR / ミトコンドリア / エネルギー代謝 / 放射線
Outline of Final Research Achievements

First of this study, we focus on Redox metabolism before and after irradiation in brain tumor stem-like cells (btSLCs). However we did not find noticeable difference between them. Next, we focus on energy metabolism in btSLCs. We found that btSLCs displayed lower oxidative phosphorylation activity and higher and lactate production than parental cells. Our findings also indicate that btSLCs metabolism plays an important role in maintaining radioresistance, and provide greater insight into the development of metabolic targeting radiotherapy to disrupt btSLCs.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (7 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] Loma Linda University Medical Center(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets2017

    • Author(s)
      Lue Sun, Takashi Moritake, Kazuya Ito, Yoshitaka Matsumoto, Hironobu Yasui, Hidehiko Nakagawa, Aki Hirayama, Osamu Inanami, and Koji Tsuboi
    • Journal Title

      PlosOns

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 包括的代謝解析による放射線抵抗性がん幹細胞の特性解析2015

    • Author(s)
      孫略、盛武敬、香﨑正宙、岡﨑龍史
    • Journal Title

      日本放射線影響学会第1回放射線ワークショップ講演論文集

      Volume: 0 Pages: 66-67

    • Related Report
      2015 Annual Research Report
  • [Presentation] Energy and ROS Metabolism in Radioresistant Brain Tumor Cells2016

    • Author(s)
      Lue Sun, Takashi Moritake, Masaoki Kohzaki, Akira Ootsuyama and Ryuji Okazaki
    • Organizer
      The Society for Redox Biology and Medicine’s 23rd Annual Meeting
    • Place of Presentation
      サンフランシスコ (アメリカ)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Energy and ROS metabolism in radioresistant brain tumor stem cells.2016

    • Author(s)
      Lue Sun
    • Organizer
      Loma Linda University Medical Center
    • Place of Presentation
      Loma Linda (アメリカ)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 包括的代謝解析による放射線抵抗性がん幹細胞の特性解析2015

    • Author(s)
      孫略、盛武敬、香﨑正宙、岡﨑龍史
    • Organizer
      日本放射線影響学会第1回放射線ワークショップ
    • Place of Presentation
      富山大学五福キャンパス(富山市、富山県)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 髄芽腫幹細胞のエネルギー代謝機構と放射線抵抗性2015

    • Author(s)
      孫略、盛武敬、香﨑正宙、岡﨑龍史
    • Organizer
      第52回放射線影響懇話会
    • Place of Presentation
      かごしま県民 交流センター(鹿児島市、鹿児島県)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2022-01-28  

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