Development of a technique to recover the decreased ability of spermatogenesis
| Project/Area Number |
15H06864
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Integrative animal science
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Suzuki Shinnosuke 国立研究開発法人理化学研究所, バイオリソースセンター, 基礎科学特別研究員 (00755994)
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 精子形成 / 精子幹細胞 / 発生・分化 / 生殖細胞 / 老化 |
|---|
| Outline of Final Research Achievements |
In this study, I focused on the differential expression patterns between germ line stem cells (GSCs) and defective GSCs (dGSCs), but I can not find a core factor of keeping the spermatogenic ability. On the other hand, I try to establish a new technique to regulate the multiple gene expression using modified genome editing technologies, CRISPR/Cas9 system, because the genes which expression are dramatically reduced in dGS cells compared to GS cells have the multiple loci and its function analysis is difficult.
|
Report
(3 results)
Research Products
(2 results)
