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Development of a technique to recover the decreased ability of spermatogenesis

Research Project

Project/Area Number 15H06864
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Integrative animal science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Suzuki Shinnosuke  国立研究開発法人理化学研究所, バイオリソースセンター, 基礎科学特別研究員 (00755994)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords精子形成 / 精子幹細胞 / 発生・分化 / 生殖細胞 / 老化
Outline of Final Research Achievements

In this study, I focused on the differential expression patterns between germ line stem cells (GSCs) and defective GSCs (dGSCs), but I can not find a core factor of keeping the spermatogenic ability. On the other hand, I try to establish a new technique to regulate the multiple gene expression using modified genome editing technologies, CRISPR/Cas9 system, because the genes which expression are dramatically reduced in dGS cells compared to GS cells have the multiple loci and its function analysis is difficult.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results)

  • [Presentation] Germline Stem (GS) 細胞における複数遺伝子の高効率機能解析技術の開発2016

    • Author(s)
      鈴木伸之介、阿部訓也
    • Organizer
      第109回日本繁殖生物学会
    • Place of Presentation
      麻布大学
    • Year and Date
      2016-09-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Germline Stem (GS) 細胞の精子形成能獲得に必要な遺伝子の探索2015

    • Author(s)
      鈴木伸之介、池田理恵子、浦大樹、佐藤卓也、小川毅彦、阿部訓也
    • Organizer
      第108回日本繁殖生物学会
    • Place of Presentation
      宮崎大学木花キャンパス
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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