| Project/Area Number |
15H06864
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Integrative animal science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Suzuki Shinnosuke 国立研究開発法人理化学研究所, バイオリソースセンター, 基礎科学特別研究員 (00755994)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 精子形成 / 精子幹細胞 / 発生・分化 / 生殖細胞 / 老化 |
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| Outline of Final Research Achievements |
In this study, I focused on the differential expression patterns between germ line stem cells (GSCs) and defective GSCs (dGSCs), but I can not find a core factor of keeping the spermatogenic ability. On the other hand, I try to establish a new technique to regulate the multiple gene expression using modified genome editing technologies, CRISPR/Cas9 system, because the genes which expression are dramatically reduced in dGS cells compared to GS cells have the multiple loci and its function analysis is difficult.
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