Development of new method for risk assessment of nanomaterials by concurrent analysis of uptake potential and toxicity using flowcytometer
| Project/Area Number |
15H06893
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | National Institute of Occupational Safety and Health,Japan |
|---|
Principal Investigator |
Toyooka Tatsushi 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 産業毒性・生体影響研究グループ, 任期付研究員 (40423842)
|
|---|
| Research Collaborator |
Miura Nobuhiko 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 産業毒性・生体影響研究グループ, 上席研究員 (20229644)
Wang Rui-sheng 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 産業毒性・生体影響研究グループ, 上席研究員 (10321895)
Ibuki Yuko 静岡県立大学, 品栄養環境科学研究院, 教授 (30236781)
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 遺伝毒性 / ナノ毒性 / ナノ粒子 / 取り込み量 / フローサイトメーター / ナノマテリアル |
|---|
| Outline of Final Research Achievements |
Establishment of a health risk-assessment method for nanomaterials is an urgent issue internationally. So far, we have developed a method for measure the intracellular uptake of nanoparticles using the side scattered light of the flow cytometer. This method canquickly and easily evaluate uptake potential of nanoparticles . On the other hand, although the method can evaluate uptake potential of nanoparticles, it is unknown what type of toxic effect is occurred. Therefore, in this study, we tried to develop a new nanomaterial evaluation method that can simultaneously analyze its toxic effects in addition to the intracellular uptake of nanomaterials.
|
Report
(3 results)
Research Products
(5 results)
