PCSK9 and coronary atherosclerosis

• Project/Area Number: 15H06914
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Kataoka Yu 国立研究開発法人国立循環器病研究センター, 病院, 医長 (70463271)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 動脈硬化症機序解明 / PCSK9 / 動脈硬化症 / 循環器 / 冠動脈硬化進展 / matured型PCSK9 / 血管内超音波

Outline of Final Research Achievements

We demonstrated that PCSK9 level, especially mature PCSK9 form associated with the extent of coronary atherosclerosis in patients with familial hypercholesterolemia. The association of PCSK9 with atherosclerotic cardiovascular events was also identified in the analysis of cohort study.

Research Products

• [Journal Article] Mature proprotein convertase subtilisin/kexin type 9, coronary atheroma burden, and vessel remodeling in heterozygous familial hypercholesterolemia. (2017)
  • Author(s): Kataoka Y, Harada-Shiba M, Nakao K, Nakashima T, Kawakami S, Fujino M, Kanaya T, Nagai T, Tahara Y, Asaumi Y, Hori M, Ogura M, Goto Y, Noguchi T, Yasuda S.
  • Journal Title: J Clin Lipidol Volume: 11 Pages: 413-421
  • Peer Reviewed
• [Presentation] 家族性高コレステロール血症におけるPCSK9と冠動脈硬化の関係 (2016)
  • Author(s): 片岡 有、中尾 一泰、野口 暉夫、安田 聡、斯波 真理子
  • Organizer: 2016年度 動脈硬化学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
• [Presentation] The Association between PCSK9 Subtype and Coronary Atherosclerosis in Familial Hypercholesterolemia: Insights from Intravascular Ultrasound (2016)
  • Author(s): 片岡 有、中尾 一泰、野口 暉夫、安田 聡、斯波 真理子
  • Organizer: 2016年度 日本循環器学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-20