主観的な時間経験の変容に関わる脳内メカニズムの解明

• Project/Area Number: 15J02216
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Brain biometrics
• Research Institution: Osaka University
• Principal Investigator: 林 正道 大阪大学, 生命機能研究科, 特別研究員(SPD)
• Project Period (FY): 2015-04-24 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 時間知覚 / 機能的MRI / 経頭蓋磁気刺激 / 経頭蓋磁気刺激法

Outline of Annual Research Achievements

主観的な時間の長さ（時間長）の変容に関わる神経基盤の解明を進めるため、前年度に取得したデータの解析を進めた。その結果、（１）右下頭頂小葉（rIPL）領域が、同一時間長の刺激の反復呈示によって応答の抑制（反復抑制）を示すこと、（２）反復抑制効果が大きい実験参加者ほど、同一時間長の繰り返し呈示による主観的時間長の変化（時間長残効）が大きいことがわかった。この結果は、rIPLが時間長残効による主観的時間長の変容と強く関連していることを示しており、rIPLの時間長選択的ニューロン群（Hayashi et al., 2015 PLoS Biology)と、主観的時間経験の変容との関連を世界で初めて示すものである。本研究成果は現在学術論文としてまとめているところであり、準備ができ次第速やかに学術誌へ論文投稿する予定である。
さらに、rIPLと主観的時間経験の因果関係の解明するため、経頭蓋磁気刺激(TMS)法により脳活動を干渉し、rIPLと主観的時間の因果関係を明らかにするための実験を行った。実験データの取得を完了し、行動データを解析した結果、rIPLの脳活動をTMSで干渉すると、（コントロール条件と比較して）時間長推定のパフォーマンスが低下することが明らかになった。rIPL領域を刺激した際に表情筋の一部を刺激していないかなど、課題パフォーマンスに影響しうる他の要因についても今後検討、解析を進め、rIPLと主観的時間経験との関係を明らかにし、まとまり次第学術誌へ論文投稿する予定である。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of California Berkeley(米国)
• [Int'l Joint Research] SISSA(イタリア)
• [Int'l Joint Research] Spinoza Centre for Neuroimaging(オランダ)
• [Int'l Joint Research] カリフォルニア大学バークレー校(米国)
• [Int'l Joint Research] University of Sussex/University College London(United Kingdom)
• [Int'l Joint Research] Aalto University/University of Helsinki(Finland)
• [Journal Article] Age-dependent abnormalities in body- and face-sensitive activation of the EBA and FFA in individuals with ASD (2017)
  • Author(s): Okamoto Y, Kosaka H, Kitada R, Seki A, Tanabe HC, Hayashi MJ, Kochiyama T, Saito DN, Yanaka HT, Munesue T, Ishitobi M, Omori M, Wada Y, Okazawa H, Koeda T, Sadato N
  • Journal Title: Neuroscience Research Volume: 印刷中 Pages: 30243-30247
  • DOI: 10.1016/j.neures.2017.02.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Brain Mechanisms for Measuring Time: Population Coding of Durations (2016)
  • Author(s): Masamichi J. Hayashi
  • Journal Title: BRAIN and NERVE Volume: 68 Issue: 11 Pages: 1385-1391
  • DOI: 10.11477/mf.1416200602
  • ISSN: 1344-8129, 1881-6096
  • Year and Date: 2016-11-01
  • Acknowledgement Compliant
• [Journal Article] Time adaptation shows duration selectivity in the human parietal cortex (2015)
  • Author(s): Hayashi MJ, Ditye T, Harada T, Hashiguchi M, Sadato N, Carlson S, et al.
  • Journal Title: PLoS Biol. Volume: 13 Issue: 9 Pages: e1002262-e1002262
  • DOI: 10.1371/journal.pbio.1002262
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Population coding of time in the human brain (2018)
  • Author(s): Hayashi MJ
  • Organizer: Post-Symposium of the 33rd Annual Meeting of the International Society for Psychophysics: Perception and the Brain
  • Int'l Joint Research / Invited
• [Presentation] Chronotopic maps in human premotor cortex (2018)
  • Author(s): Protopapa F, Hayashi MJ, van der Zwaag W, Battistella G, Murray MM, Kanai R, and Bueti D
  • Organizer: Annual Meeting of the Vision Science Society 2018
  • Int'l Joint Research
• [Presentation] Decoding time in the human frontal and parietal cortices (2018)
  • Author(s): Hayashi MJ, van der Zwaag W, Bueti D, and Kanai R
  • Organizer: 24th Annual Meeting of the Organization for Human Brain Mapping
  • Int'l Joint Research
• [Presentation] How do “duration selective” brain regions communicate? (2018)
  • Author(s): Protopapa F, Hayashi MJ, and Bueti D
  • Organizer: 41st European Conference on Visual Perception
  • Int'l Joint Research
• [Presentation] Neural population code in the right parietal cortex mediates subjective experience of time (2018)
  • Author(s): Hayashi MJ
  • Organizer: 41st European Conference on Visual Perception
  • Int'l Joint Research / Invited
• [Presentation] Neural correlates of aftereffects observed following duration adaptation (2017)
  • Author(s): Hayashi MJ, Levine DM, and Ivry RB
  • Organizer: The 2nd International Symposium on the Science of Mental Time
  • Int'l Joint Research
• [Presentation] Exaggerated groups: Amplification in temporal and spatial ensemble features (2017)
  • Author(s): Kanaya S, Hayashi MJ, and Whitney D
  • Organizer: The 2nd International Symposium on the Science of Mental Time
  • Int'l Joint Research
• [Presentation] Time in the Brain: Neuronal Coding of Duration (2017)
  • Author(s): Hayashi MJ
  • Organizer: The 33rd Annual Meeting of the International Society for Psychophysics
  • Int'l Joint Research / Invited
• [Presentation] 知覚される平均値はセットサイズに応じて拡大する (2017)
  • Author(s): 金谷翔子、林正道、and David Whitney
  • Organizer: 第36回日本基礎心理学会大会
• [Presentation] Summary statistic representation of temporal frequency (2017)
  • Author(s): Kanaya S, Hayashi MJ, and Whitney D
  • Organizer: Annual Meeting of the Vision Science Society 2017
  • Int'l Joint Research
• [Presentation] Duration adaptation improves time sensitivity (2016)
  • Author(s): Hayashi MJ, Hoherchak N, Ivry RB
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego（米国）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] ge-dependent abnormalities in body- and face-sensitive activation of the EBA and FFA in children with ASD (2016)
  • Author(s): Okamoto Y, Kosaka H, Kitada R, Seki A, Tanabe HC, Hayashi MJ, Kochiyama T, Saito DN, Yanaka HT, Munesue T, Ishitobi M, Omori M, Wada Y, Okazawa H, Koeda T, Sadato N
  • Organizer: The 46the Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego（米国）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Neural population coding of time in the parietal and medial premotor cortex (2016)
  • Author(s): Masamichi J. Hayashi
  • Organizer: Time in Tokyo: International symposium on temporal perception and experience
  • Place of Presentation: ENEOSホール（東京都目黒区）
  • Year and Date: 2016-10-11
  • Int'l Joint Research / Invited
• [Presentation] 自閉症スペクトラム症における顔認知・身体認知に関与する視覚領域の発達遅延 (2016)
  • Author(s): 岡本悠子, 小坂浩隆, 北田亮, 関あゆみ, 田邊宏樹, 林正道, 河内山隆紀, 齋藤大輔, 谷中久和, 棟居俊夫, 石飛信, 大森晶夫, 和田有司, 岡沢秀彦, 小枝達也, 定藤規弘
  • Organizer: 第18回日本ヒト脳機能マッピング学会大会
  • Place of Presentation: 京都大学桂キャンパス船井哲良記念講堂（京都府京都市）
  • Year and Date: 2016-03-07
• [Presentation] Duration-selective adaptation in the human parietal cortex (2015)
  • Author(s): Hayashi MJ, Ditye T, Harada T, Hashiguchi M, Sadato N, Carlson S, Walsh V, Kanai R
  • Organizer: 2015年度包括型脳科学研究推進ネットワーク冬のシンポジウム
  • Place of Presentation: 一橋大学一橋講堂（東京都千代田区）
  • Year and Date: 2015-12-18
• [Presentation] Duration-selective adaptation in the human parietal cortex (2015)
  • Author(s): Hayashi MJ, Ditye T, Harada T, Hashiguchi M, Sadato N, Carlson S, Walsh V, Kanai R
  • Organizer: International Symposium on the Science of Mental Time
  • Place of Presentation: 東京工業大学キャンパス・イノベーションセンター（東京都港区）
  • Year and Date: 2015-09-12
  • Int'l Joint Research
• [Presentation] Neural population code for time in parietal and medial premotor cortex (2015)
  • Author(s): Hayashi MJ
  • Organizer: The 38th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-28
  • Int'l Joint Research