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心血管疾患リスクおよび死亡率の関連因子としての精神ストレス

Research Project

Project/Area Number 15J05980
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Epidemiology and preventive medicine
Research InstitutionThe University of Tokyo

Principal Investigator

SVENSSON THOMAS  東京大学, 医学系研究科, 特別研究員(DC2)

Project Period (FY) 2015-04-24 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2016: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2015: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsCoping / Stress / Cardiovascular disease / Cancer / Epidemiology / Cohort / Incidence / Mortality
Outline of Annual Research Achievements

My research over the past two years has progressed in accordance with the initial timeline defined in my grant application.
The first goal was to investigate the association between stress coping strategies and disease. This has been accomplished and resulted in two publications of which one was considered Editors’Choice. The results of the second article were highlighted by NHK News.
The second goal was to investigate if genetic susceptibility to coronary heart disease modified the effect of stress on cardiovascular disease. The results of this study were presented at the prestigious ESC Congress in Rome, and the manuscript has been accepted for publication in PLOS ONE.
I have also managed additional publications outside the current grant proposal (for details, please see below).

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (13 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 5 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Remarks (3 results)

  • [Int'l Joint Research] Lund University(Sweden)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Psychological stress and risk of incident atrial fibrillation in men and women with known atrial fibrillation genetic risk scores2017

    • Author(s)
      Svensson T, Kitlinski M, Engstrom G, Melander O.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/srep42613

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death2017

    • Author(s)
      Svensson T, Kitlinski M, Engstrom G, Melander O.
    • Journal Title

      PLOS ONE

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Coping strategies and risk of cardiovascular disease incidence and mortality: The Japan Public Health Center-based prospective Study2016

    • Author(s)
      Svensson T, Inoue M, Sawada N, Yamagishi K, Charvat H, Saito I, Kokubo Y, Iso H, Kawamura N, Shibuya K, Mimura M, Tsugane S
    • Journal Title

      Eur Heart J

      Volume: 37 Issue: 11 Pages: 890

    • DOI

      10.1093/eurheartj/ehv724

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Coping strategies and cancer incidence and mortality: The Japan Public Health Center-based prospective study2016

    • Author(s)
      Svensson T, Inoue M, Sawada N, Charvat H, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kawamura N, Shibuya K, Mimura M, Tsugane S.
    • Journal Title

      Cancer Epidemiology

      Volume: 40 Pages: 126

    • DOI

      10.1016/j.canep.2015.12.003

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study2016

    • Author(s)
      Svensson T, Yamaji T, Budhathoki S, Hidaka A, Iwasaki M, Sawada N, Inoue M, Sasazuki S, Shimazu T, Tsugane S
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 36607-36607

    • DOI

      10.1038/srep36607

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk2015

    • Author(s)
      Melander O, Orho-Melander M, Manjer J, Svensson T, Almgren P, Nilsson PM, Engstrom G, Hedblad B, Borgquist S, Hartmann O, Struck J, Bergmann A, Belting M.
    • Journal Title

      Journal of Clinical Oncology

      Volume: 33 Issue: 24 Pages: 2632-2638

    • DOI

      10.1200/jco.2014.59.7682

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The association between complete and partial non-response to psychosocial questions and suicide: the JPHC Study2015

    • Author(s)
      Svensson T, Inoue M, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Ikeda A, Kawamura N, Mimura M, Tsugane S
    • Journal Title

      European Journal of Public Health

      Volume: 25 Issue: 3 Pages: 424-430

    • DOI

      10.1093/eurpub/cku209

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Coping strategies and cancer incidence and mortality: The Japan Public Health Center-based prospective study2016

    • Author(s)
      Thomas Svensson
    • Organizer
      International Congress of Behavioural Medicine
    • Place of Presentation
      Melbourne,Australia
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic Risk Score, individual genetic variants and psychological stress as predictors of CAD, fatal MI and cardiovascular death2016

    • Author(s)
      Thomas Svensson
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Rome,Italy
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] Department of Clinical Sciences

    • URL

      http://www.med.lu.se/english/klinvetmalmo/about_the_department

    • Related Report
      2016 Annual Research Report
  • [Remarks] がんセンター リサーチニュース

    • URL

      http://epi.ncc.go.jp/jphc/773/3782.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] NHK ニュース, 科学文化部ブログ 「 積極的に計画・実行する人"がん死亡リスク低い」

    • URL

      http://www9.nhk.or.jp/kabun-blog/200/239184.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-11-26   Modified: 2024-03-26  

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