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Development of Nonlinear Regression Analyses for Personalized Medicine

Research Project

Project/Area Number 15K00044
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Statistical science
Research InstitutionWakayama Medical University

Principal Investigator

Shimokawa Toshio  和歌山県立医科大学, 医学部, 教授 (00402090)

Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords樹木構造接近法 / アンサンブル学習法 / 治療効果(treatment effect) / 生存時間解析 / 多変量適応型回帰スプライン(MARS) / ルールアンサンブル法 / 治療効果 / 傾向スコア / 観察研究 / 境界内生存期間 / 非比例ハザード性 / レスポンダー同定手法 / サブグループ抽出手法 / 無作為化比較試験 / 適応的指標モデル / ブースティング / 競合リスク / 多変量適応型回帰スプライン / ルール・アンサンブル法 / 順序カテゴリカル応答
Outline of Final Research Achievements

In recent years, personalized medicine, in which optimal treatment is provided to each patient based on registry data or large clinical trials, has been attracting attention.Nonlinear regression methods with treatment × background factors or treatment × gene information interactions have been developed.In addition, statistical methods for predicting the treatment effect (the difference between new and existing treatments/drugs) have recently received much attention.In this study, we have developed a statistical method based on the tree model and its extension to achieve the above goals.

Academic Significance and Societal Importance of the Research Achievements

この研究では,近年注目されている疾患レジストリ及び大規模臨床試験データに基づいて,治療効果を推定するための方法を開発した.このような方法は,治療効果モデル(treatment effect model)と呼ばれ,近年注目されている.一方で,医学においてニーズの高い,生存時間データにおける開発は発展途上である.本研究では,生存時間データに対する非線形回帰モデルに基づく治療効果推定の方法を開発した.これらを疾患レジストリデータに応用することで,複数の治療レジメンの中から最適な治療法をがん患者に届けることができる.

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (70 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (45 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 44 results,  Open Access: 20 results) Presentation (21 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] 四川大学(中国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Diffusion-weighted MRI predicts the histologic response for neoadjuvant therapy in patients with pancreatic cancer: a prospective study (DIFFERENT trial)2020

    • Author(s)
      Okada Ken-ichi、Kawai Manabu、Hirono Seiko、Kojima Fumiyoshi、Tanioka Kensuke、Terada Masaki、Miyazawa Motoki、Kitahata Yuji、Iwahashi Yoshifumi、Ueno Masaki、Hayami Shinya、Murata Shin-ichi、Shimokawa Toshio、Yamaue Hiroki
    • Journal Title

      Langenbeck's Archives of Surgery

      Volume: 405 Issue: 1 Pages: 23-33

    • DOI

      10.1007/s00423-020-01857-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fully covered self-expandable metal stent with an anti-migration system vs plastic stent for distal biliary obstruction caused by borderline resectable pancreatic cancer2020

    • Author(s)
      Tamura Takashi、Yamaue Hiroki、Itonaga Masahiro、Kawaji Yuki、Nuta Junya、Hatamaru Keiichi、Yamashita Yasunobu、Kitahata Yuji、Miyazawa Motoki、Hirono Seiko、Okada Ken-ichi、Kawai Manabu、Shimokawa Toshio、Kitano Masayuki
    • Journal Title

      Medicine

      Volume: 99 Issue: 3 Pages: e18718-e18718

    • DOI

      10.1097/md.0000000000018718

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence patterns after surgical resection of intraductal papillary mucinous neoplasm (IPMN) of the pancreas; a multicenter, retrospective study of 1074 IPMN patients by the Japan Pancreas Society.2020

    • Author(s)
      Hirono S, Shimizu Y, Ohtsuka T, Kin T, Hara K, Kanno A,et al.
    • Journal Title

      J Gastroenterol.

      Volume: 55 Issue: 1 Pages: 86-99

    • DOI

      10.1007/s00535-019-01617-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Five-year outcomes of a phase II study of adjuvant chemotherapy with S-1 plus docetaxel for stage III gastric cancer after curative D2 gastrectomy (OGSG1002)2019

    • Author(s)
      Fujitani Kazumasa、the Osaka Gastrointestinal Cancer Chemotherapy Study Group、Tamura Shigeyuki、Kimura Yutaka、Matsuyama Jin、Imamura Hiroshi、Yamamoto Kazuyoshi、Fujita Junya、Iijima Shohei、Ueda Shugo、Kurokawa Yukinori、Shimokawa Toshio、Satoh Taroh
    • Journal Title

      Gastric Cancer

      Volume: 23 Issue: 3 Pages: 520-530

    • DOI

      10.1007/s10120-019-01023-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Phase II Study of Perioperative Capecitabine plus Oxaliplatin Therapy for Clinical SS/SE N1‐3 M0 Gastric Cancer (OGSG 1601)2019

    • Author(s)
      Terazawa Tetsuji、Matsuyama Jin、Goto Masahiro、Kawabata Ryohei、Endo Shunji、Imano Motohiro、Fujita Shoichiro、Akamaru Yusuke、Taniguchi Hirokazu、Tatsumi Mitsutoshi、Lee Sang‐Woong、Kurisu Yoshitaka、Kawakami Hisato、Kurokawa Yukinori、Shimokawa Toshio、Sakai Daisuke、Kato Takeshi、Fujitani Kazumasa、Satoh Taroh
    • Journal Title

      The Oncologist

      Volume: 25 Issue: 2 Pages: 119-119

    • DOI

      10.1634/theoncologist.2019-0601

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of standard and high dose of rikkunshito on achievement of enteral nutrition target in critically ill patients: a pilot randomized controlled trial2019

    • Author(s)
      Doi Mitsunori、Miyamoto Kyohei、Shimokawa Toshio、Ariyasu Hiroyuki、Kaneko Masahiro、Yonemitsu Takafumi、Nakashima Tsuyoshi、Matsumoto Haruka、Shibata Mami、Shibata Naoaki、Soda Midori、Kitaichi Kiyoyuki、Kato Seiya
    • Journal Title

      Acute Medicine & Surgery

      Volume: 7 Issue: 1 Pages: 442-442

    • DOI

      10.1002/ams2.442

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of 22G standard and Franseen needles in endoscopic ultrasound-guided fine-needle aspiration for diagnosing pancreatic mass lesions: Study protocol for a controlled trial2019

    • Author(s)
      Itonaga Masahiro、Yasukawa Satoru、Shimokawa Toshio、Takenaka Mamoru、Fukutake Nobuyasu、Ogura Takeshi、Sakagami Junichi、Shiomi Hideyuki、Okura Yasushi、Inatomi Osamu、Matsumoto Hisakazu、Kurita Akira、Suzuki Azumi、Tanaka Kiyohito、Kitano Masayuki
    • Journal Title

      Trials

      Volume: 20 Issue: 1

    • DOI

      10.1186/s13063-019-3946-7

    • NAID

      120006873035

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Furosemide versus mannitol in Japanese patients with thoracic malignancy who received cisplatin-based chemotherapy using short hydration: study protocol for a randomised controlled trial2019

    • Author(s)
      Murakami Eriko、Akamatsu Hiroaki、Shimokawa Toshio、Wada Kiyoko、Yamamoto Nobuyuki
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 12 Pages: e029057-e029057

    • DOI

      10.1136/bmjopen-2019-029057

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Value of contrast‐enhanced harmonic endoscopic ultrasonography with enhancement pattern for diagnosis of pancreatic cancer: A meta‐analysis2019

    • Author(s)
      Yamashita Y, Shimokawa T, Napoléon B, Fusaroli P, Gincul R, Kudo M, Kitano M
    • Journal Title

      Digestive Endoscopy

      Volume: 31 Issue: 2 Pages: 125-133

    • DOI

      10.1111/den.13290

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] First-line single-agent panitumumab in frail elderly patients with wild-type RAS unresectable colorectal cancer: a phase II study protocol OGSG 16022019

    • Author(s)
      Terazawa Tetsuji、Kato Takeshi、Goto Masahiro、Sakai Daisuke、Kurokawa Yukinori、Shimokawa Toshio、Matsubara Yoshihiro、Satoh Taroh
    • Journal Title

      BMC Cancer

      Volume: 19 Issue: 1 Pages: 623-623

    • DOI

      10.1186/s12885-019-5821-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long‐term effects of an oral elemental nutritional supplement on post‐gastrectomy body weight loss in gastric cancer patients (KSES002)2019

    • Author(s)
      Kimura Yutaka、Nishikawa Kazuhiro、Kishi Kentaro、Inoue Kentaro、Matsuyama Jin、Akamaru Yusuke、Tamura Shigeyuki、Kawada Junji、Kawase Tomono、Kawabata Ryohei、Fujiwara Yoshiyuki、Kanno Hitoshi、Yamada Takeshi、Shimokawa Toshio、Imamura Hiroshi
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 3 Issue: 6 Pages: 648-656

    • DOI

      10.1002/ags3.12290

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Triplet chemotherapy with docetaxel, cisplatin and S-1 for unresectable advanced squamous cell carcinoma of the esophagus: phase I/II trial results2019

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 8 Pages: 847-855

    • DOI

      10.18632/oncotarget.26614

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trastuzumab With S-1 Plus Cisplatin in HER2-positive Advanced Gastric Cancer Without Measurable Lesions: OGSG 12022019

    • Author(s)
      Endo S, Kurokawa Y, Gamoh M, Kimura Y, Matsuyama J, Taniguchi H, Takeno A, Kawabata R, Kawada J, Masuzawa T, Yamamoto K, Kobayashi K, Sakai D, Shimokawa T, Satoh T.
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 2 Pages: 1059-1065

    • DOI

      10.21873/anticanres.13213

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Triangulating stapling vs functional end-to-end stapling for cervical esophagogastric anastomosis after esophagectomy for thoracic esophageal cancer: study protocol for a randomized controlled trial2019

    • Author(s)
      Tsuji T, Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Trials

      Volume: 20 Issue: 1 Pages: 83-83

    • DOI

      10.1186/s13063-019-3201-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MAPLE-PD trial (Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer during Pancreaticoduodenectomy): study protocol for a multicenter randomized controlled trial of 354 patients with pancreatic ductal adenocarcinoma2018

    • Author(s)
      Hirono S, Kawai M, Okada KI, Fujii T, Sho M, Satoi S, Amano R, Eguchi H, Mataki Y, Nakamura M, Matsumoto I, Baba H, Tani M, Kawabata Y, Nagakawa Y, Yamada S, Murakami Y, Shimokawa T, Yamaue H.
    • Journal Title

      Trials

      Volume: 19 Issue: 1 Pages: 613-613

    • DOI

      10.1186/s13063-018-3002-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intensive perioperative rehabilitation improves surgical outcomes after pancreaticoduodenectomy2018

    • Author(s)
      Kitahata Y, Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kobayashi R, Ueno M, Hayami S, Shimokawa T, Kouda K, Tajima F, Yamaue H.
    • Journal Title

      Langenbeck's Archives of Surgery

      Volume: 403 Issue: 6 Pages: 711-718

    • DOI

      10.1007/s00423-018-1710-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Osimertinib With Ramucirumab in EGFR-mutated, T790M-positive Patients With Progression During EGFR-TKI Therapy: Phase Ib Study2018

    • Author(s)
      Akamatsu H, Koh Y, Ozawa Y, Fujimoto D, Hata A, Katakami N, Tomii K, Shimokawa T, Yamamoto N.
    • Journal Title

      Clinical Lung Cancer

      Volume: 19 Issue: 6 Pages: e871-e874

    • DOI

      10.1016/j.cllc.2018.08.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomized, Open‐Label Phase II Study Comparing Capecitabine‐Cisplatin Every 3 Weeks with S‐1‐Cisplatin Every 5 Weeks in Chemotherapy‐Na?ve Patients with HER2‐Negative Advanced Gastric Cancer: OGSG1105, HERBIS‐4A Trial2018

    • Author(s)
      Kawakami H, Takeno A, Endo S, Makari Y, Kawada J, Taniguchi H, Tamura S, Sugimoto N, Kimura Y, Tamura T, Fujitani K, Sakai D, Shimokawa T, Kurokawa Y, Satoh T.
    • Journal Title

      The Oncologist

      Volume: 23 Issue: 12 Pages: 1411-e147

    • DOI

      10.1634/theoncologist.2018-0175

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Robotic versus laparoscopic gastrectomy with lymph node dissection for gastric cancer: study protocol for a randomized controlled trial2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Trials

      Volume: 19 Issue: 1 Pages: 409-409

    • DOI

      10.1186/s13063-018-2810-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enzalutamide Versus Abiraterone as a First-Line Endocrine Therapy for Castration-Resistant Prostate Cancer: Protocol for a Multicenter Randomized Phase 3 Trial2018

    • Author(s)
      Hara I, Yamashita S, Nishizawa S, Kikkawa K, Shimokawa T, Kohjimoto Y.
    • Journal Title

      JMIR Research Protocols

      Volume: 7 Issue: 7 Pages: e11191-e11191

    • DOI

      10.2196/11191

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Splenic vein resection together with the pancreatic parenchyma versus separated resection after isolation of the parenchyma during distal pancreatectomy (COSMOS-DP trial): study protocol for a randomised controlled trial2018

    • Author(s)
      Yamada S, Fujii T, Kawai M, Shimokawa T, Nakamura M, Murakami Y, Satoi S, Eguchi H, Nagakawa Y, Kodera Y, Yamaue H.
    • Journal Title

      Trials

      Volume: 19 Issue: 1 Pages: 369-369

    • DOI

      10.1186/s13063-018-2756-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ischemic gastropathy after distal pancreatectomy with en bloc celiac axis resection for pancreatic body cancer2018

    • Author(s)
      Okada KI, Kawai M, Hirono S, Miyazawa M, Kitahata Y, Ueno M, Hayami S, Shimokawa T, Yamaue H.
    • Journal Title

      Langenbeck's Archives of Surgery

      Volume: 403 Issue: 5 Pages: 561-571

    • DOI

      10.1007/s00423-018-1692-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study2018

    • Author(s)
      Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K, Shimokawa T.
    • Journal Title

      Journal of Gastroenterology

      Volume: 54 Issue: 2 Pages: 122-130

    • DOI

      10.1007/s00535-018-1487-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase I/II Trial of Chemotherapy with Docetaxel, Cisplatin, and S-1 for Unresectable Advanced Squamous Cell Carcinoma of the Esophagus2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Oncology

      Volume: 95 Issue: 2 Pages: 116-120

    • DOI

      10.1159/000488861

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repetitive transcranial magnetic stimulation accuracy as a spinal cord stimulation outcome predictor in patients with neuropathic pain2018

    • Author(s)
      Shimizu T, Hosomi K, Maruo T, Goto Y, Shimokawa T, Haruhiko K, Saitoh Y.
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 53 Pages: 100-105

    • DOI

      10.1016/j.jocn.2018.04.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The optimal stimulation site for high-frequency repetitive transcranial magnetic stimulation in Parkinson’s disease: A double-blind crossover pilot study2018

    • Author(s)
      Yokoe Masaru、Mano Tomoo、Maruo Tomoyuki、Hosomi Koichi、Shimokawa Toshio、Kishima Haruhiko、Oshino Satoru、Morris Shayne、Kageyama Yu、Goto Yuko、Shimizu Takeshi、Mochizuki Hideki、Yoshimine Toshiki、Saitoh Youichi
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 47 Pages: 72-78

    • DOI

      10.1016/j.jocn.2017.09.023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delineation of the extent of early gastric cancer by magnifying narrow-band imaging and chromoendoscopy: a multicenter randomized controlled trial2018

    • Author(s)
      Takashi Nagahama, Kenshi Yao, Noriya Uedo, Hisashi Doyama, Tetsuya Ueo, Kunihisa Uchita, Hideki Ishikawa, Takashi Kanesaka, Yasuhito Takeda, Kurato Wada, Kentaro Imamura, Hisatomi Arima, Toshio Shimokawa
    • Journal Title

      Endoscopy

      Volume: - Issue: 06 Pages: 566-576

    • DOI

      10.1055/s-0044-100790

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison between Optical COherence tomography guidance and Angiography guidance in percutaneous coronary intervention (COCOA): Study protocol for a randomized controlled trial2018

    • Author(s)
      Kubo Takashi、Shinke Toshiro、Okamura Takayuki、Hibi Kiyoshi、Nakazawa Gaku、Morino Yoshihiro、Shite Junya、Ino Yasushi、Kitabata Hironori、Shimokawa Toshio、Akasaka Takashi
    • Journal Title

      Journal of Cardiology

      Volume: - Issue: 2 Pages: 170-175

    • DOI

      10.1016/j.jjcc.2018.01.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II study of neoadjuvant imatinib in large gastrointestinal stromal tumours of the stomach2017

    • Author(s)
      Kurokawa Yukinori、Yang Han-Kwang、Cho Haruhiko、Ryu Min-Hee、Masuzawa Toru、Park Sook Ryun、Matsumoto Sohei、Lee Hyuk-Joon、Honda Hiroshi、Kwon Oh Kyoung、Ishikawa Takashi、Lee Kyung Hee、Nabeshima Kazuhito、Kong Seong-Ho、Shimokawa Toshio、et al.
    • Journal Title

      British Journal of Cancer

      Volume: 117 Issue: 1 Pages: 25-32

    • DOI

      10.1038/bjc.2017.144

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kitwsh/wsh mutation2017

    • Author(s)
      Inaba Yutaka、Kanazawa Nobuo、Yoshimasu Takashi、Shimokawa Toshio、Nosaka Mizuho、Kondo Toshikazu、Furukawa Fukumi
    • Journal Title

      Modern Rheumatology

      Volume: 28 Issue: 2 Pages: 319-326

    • DOI

      10.1080/14397595.2017.1341591

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Neoadjuvant Nab-Paclitaxel plus Gemcitabine Therapy on Overall Survival in Patients with Borderline Resectable Pancreatic Cancer: A Prospective Multicenter Phase II Trial (NAC-GA Trial)2017

    • Author(s)
      Okada Ken-ichi、Shimokawa Toshio、Hirono Seiko、Kawai Manabu、Sho Masayuki、Satoi Sohei、Matsumoto Ippei、Eguchi Hidetoshi、Murakami Yoshiaki、Yamada Suguru、Doi Mariko、Yamaue Hiroki、the NAC-GA investigators
    • Journal Title

      Oncology

      Volume: 93 Issue: 5 Pages: 343-346

    • DOI

      10.1159/000478660

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severity of Premenstrual Symptoms Predicted by Second to Fourth Digit Ratio2017

    • Author(s)
      Kaneoke Yoshiki、Donishi Tomohiro、Iwahara Akihiko、Shimokawa Toshio
    • Journal Title

      Frontiers in Medicine

      Volume: 4

    • DOI

      10.3389/fmed.2017.00144

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular diagnosis of lymph node metastasis in patients with upper urinary tract cancer who underwent lymphadenectomy2017

    • Author(s)
      Kodama Yoshiki、Kondo Tsunenori、Matsumura Nagahide、Shimokawa Toshio、Kohjimoto Yasuo、Tanabe Kazunari、Hara Isao
    • Journal Title

      International Journal of Urology

      Volume: 24 Issue: 11 Pages: 799-806

    • DOI

      10.1111/iju.13429

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postoperative Visceral Tissue Edema Assessed by Computed Tomography Is a Predictor for Severe Complications After Pancreaticoduodenectomy2017

    • Author(s)
      Shimizu Atsushi、Kawai Manabu、Hirono Seiko、Okada Ken-ichi、Miyazawa Motoki、Kitahata Yuji、Ueno Masaki、Hayami Shinya、Miyamoto Atsushi、Kimoto Yoshiki、Shimokawa Toshio、Yamaue Hiroki
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: 22 Issue: 1 Pages: 77-87

    • DOI

      10.1007/s11605-017-3608-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective validation of patient fatigue questionnaire (FACIT?F) for fatigue assessment in nab?paclitaxel plus gemcitabine therapy2017

    • Author(s)
      Okada Ken-Ichi、Hirono Seiko、Kawai Manabu、Miyazawa Motoki、Shimizu Atsushi、Kitahata Yuji、Ueno Masaki、Hayami Shinya、Shimokawa Toshio、Yamaue Hiroki
    • Journal Title

      Molecular and Clinical Oncology

      Volume: - Pages: 121-126

    • DOI

      10.3892/mco.2017.1485

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extending magnifying NBI diagnosis of intestinal metaplasia in the stomach: the white opaque substance marker2017

    • Author(s)
      Kanemitsu T., Yao K., Nagahama T., Imamura K., Fujiwara S., Ueki T., Chuman K., Tanabe H., Atsuko O., Iwashita A., Shimokawa T., Uchita K., Kanesaka T.
    • Journal Title

      Endoscopy

      Volume: - Issue: 06 Pages: 529-535

    • DOI

      10.1055/s-0043-103409

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients: A randomized controlled clinical trial2016

    • Author(s)
      Imamura H, Nishikawa K, Kishi K, Inoue K, Matsuyama J, Akamaru Y, Kimura Y, Tamura S, Kawabata R, Kawada J, Fujiwara Y, Kawase T, Fukui J, Takagi M, Takeno A, Shimokawa T.
    • Journal Title

      Ann Surg Oncol.

      Volume: 23 Issue: 9 Pages: 2928-2935

    • DOI

      10.1245/s10434-016-5221-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Preoperative neoadjuvant chemotherapy using nanoparticle albumin-bound paclitaxel followed by epirubicin and cyclophosphamide for operable breast cancer: a multicenter phase II trial2016

    • Author(s)
      Futamura M., Nagao Y., Ishihara K., Takeuchi M., Nakada T., Kawaguchi Y., Asano M., Kumazawa I., Shiroko T., Morimitsu K., Mori R., Nawa M., Shimokawa T., Yoshida K.
    • Journal Title

      Breast Cancer

      Volume: - Issue: 4 Pages: 615-623

    • DOI

      10.1007/s12282-016-0748-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 成都市および近郊地域における観光地開発の現況:中国における伝統的観光地の顧客ニーズ調査2016

    • Author(s)
      劉 岩・万 可・李 力・下川敏雄
    • Journal Title

      日本感性工学会論文誌

      Volume: 15 Pages: 163-172

    • NAID

      130005128766

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus2015

    • Author(s)
      69.Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, Yanagisawa T, Kazui H, Watanabe Y, Shimokawa T, Aso T, Kawaguchi A, Yamashita F, Saitoh Y and Yoshimine T
    • Journal Title

      Journal of Neurosurgery

      Volume: 124 Pages: 350-358

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elemental diet plus glutamine for the prevention of mucositis in esophageal cancer patients receiving chemotherapy:a feasibility study2015

    • Author(s)
      68.Tanaka Y, Takahashi T, Osada S, Shimokawa T and Yoshida K
    • Journal Title

      Support Care Cancer

      Volume: 24 Pages: 933-941

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highest power magnification with narrow-band imaging is useful for improving diagnostic performance for endoscopic delineation of early gastric cancers2015

    • Author(s)
      67.Uchita K*, Yao K, Uedo N, Shimokawa T, Iwasaki T, Kojima K, Kawada A, Nakayama M, Okazaki M, Iwamura S
    • Journal Title

      BMC Gastroenterol.

      Volume: 15 Issue: 1

    • DOI

      10.1186/s12876-015-0385-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipid is absorbed in the stomach by epithelial neoplasms (adenomas and early cancers):a novel functional endoscopy technique2015

    • Author(s)
      66.Ohtsu K*, Yao K, Matsunaga K, Nagahama T, Kanemitsu T, Matsushima Y, Yasaka M, Ono Y, Fujiwara S, Hisabe T, Takaki Y, Hirai F, Matsui T, Hanada T, Imamura K, Tanabe H, Iwashita A, Shimokawa T
    • Journal Title

      Endoscopy International Open

      Volume: 3 Issue: 04 Pages: E318-E322

    • DOI

      10.1055/s-0034-1392095

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 山梨県におけるNPO法人の持続可能性に関するヒアリング調査の計量的分析2015

    • Author(s)
      王 娜・下川敏雄・大山 勲・北村眞一
    • Journal Title

      日本感性工学会論文誌

      Volume: 14 Pages: 207-214

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 順序カテゴリカル応答に対する多変量適応型回帰スプライン法2015

    • Author(s)
      下川敏雄・辻 光宏・後藤昌司
    • Journal Title

      計算機統計学

      Volume: 28 Pages: 121-136

    • NAID

      130005631736

    • Related Report
      2015 Research-status Report
    • Open Access
  • [Presentation] Box-Cox変換に基づく共変量調整済み治療効果の推定方法について2019

    • Author(s)
      高塚絵理子・谷岡健資・下川敏雄
    • Organizer
      日本計算機統計学会 第33回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 治療効果を推定するための多変量適応型回帰スプライン法2019

    • Author(s)
      下川敏雄
    • Organizer
      日本計算機統計学会 第33回シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] ガンマ・ダイバージェンスに基づくロバストな治療効果推定モデルの構築2019

    • Author(s)
      渡邊雄大・谷岡健資・下川敏雄
    • Organizer
      日本計算機統計学会 第33回シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大規模疾患レジストリ研究におけるR markdownによるデータマネジメントシステムの開発とその評価2019

    • Author(s)
      北山恵・谷岡健資・吉本世一・土井麻理子・下川敏雄・丹生健一・林隆一
    • Organizer
      日本計算機統計学会 第33回シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 治療効果を推定するためのルール・アンサンブル・モデルの開発2019

    • Author(s)
      下川敏雄
    • Organizer
      2019年度 日本分類学会シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 二重ベキ加法化変換を用いた応答の予測2019

    • Author(s)
      吉川隆範・下川敏雄・越智義道・後藤昌司
    • Organizer
      2019年度 日本分類学会シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] レジストリ研究における施設別でのリスク評価を実施するための視覚化システムの開発2019

    • Author(s)
      平石麻友・谷岡健資・下川敏雄
    • Organizer
      日本臨床試験学会第10回学術集会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 北山恵・谷岡健資・下川敏雄2018

    • Author(s)
      臨床試験におけるクエリ発行に関する適切性の評価:シミュレーションに基づく検討
    • Organizer
      2018 年度日本分類学会シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 生存時間研究における治療効果分類のための生存時間樹木法の開発2018

    • Author(s)
      下川敏雄
    • Organizer
      2018年度 統計関連学会連合大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統計的機械学習法に基づくサブグループ同定手法2017

    • Author(s)
      下川敏雄
    • Organizer
      2017年度 日本計量生物学会年会
    • Place of Presentation
      中央大学後楽園キャンパス
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 2値応答に対するハイブリッド型適応的指示モデルの開発2017

    • Author(s)
      万可,谷岡健資,下川敏雄
    • Organizer
      日本計算機統計学会 第31回シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] Adjusted adaptive index model for binary response2017

    • Author(s)
      Ke Wan, Kensuke Tanioka Kun Yang, Toshio Shimokawa
    • Organizer
      2017 IASC/NZSA Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Two stage approach to data-driven subgroup identification in clinical trials2017

    • Author(s)
      Toshio Shimokawa, Kensuke Tanioka
    • Organizer
      2017 IASC/NZSA Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 樹木モデルに基づく治療効果のサブグループ摘出手法とその応用2016

    • Author(s)
      下川敏雄
    • Organizer
      日本計算機統計学会 第31回シンポジウム
    • Place of Presentation
      静岡県 沼津市
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 多重性を考慮した無作為化比較第 II 相試験の2 段階デザインとその評価2016

    • Author(s)
      谷岡健資,下川敏雄
    • Organizer
      日本計算機統計学会 第31回シンポジウム
    • Place of Presentation
      静岡県 沼津市
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report
  • [Presentation] A phase II trial of trastuzumab combined with irinotecan in patients with advanced HER2-positive chemo-refractory gastric cancer:OGSG1203 (HERBIS-5)2016

    • Author(s)
      41.Nishikawa K, Sakai D, Kawada J, Kawabata R, Kawase T, Oka Y, Sugimoto B, Shimizu T, Nishijima J, Hasegawa H, Endo S, Isozaki Y, Kimura Y, Matsuyama J, Kurokawa Y, Shimokawa T, Fujitani K, Satoh T
    • Organizer
      2016 Gastrical Cancers Symposum, American Society of Clinical Oncology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] A multinational phase II clinical trial of neoadjuvant imatinib for large gastrointestinal stromal tumor of the stomach2016

    • Author(s)
      42.Yang HK, Kurokawa Y, Ryu HM, Cho H, Park SR, Masuzawa T, Lee HJ, Matsumoto S, Kwon OK, Honda H, Lee KH, Yamamoto K, Kong SH, Ishikawa T, Yook JH, Nabeshima K, Hahn S, Shimokawa T, Kang YK, Nishida T
    • Organizer
      2016 Gastrical Cancers Symposum, American Society of Clinical Oncology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] A phase II trial of trastuzumab combined with irinotecan in patients with advanced HER2-positive chemo-refractory gastric cancer:Osaka Gastrointestinal Cancer Chemotherapy Study Group OGSG1203 (HERBIS-5)2015

    • Author(s)
      40.Kawabata R, Sakai D, Kawada J, Nishikawa K, Kawase T, Oka Y, Sugimoto N, Shimizu T, Nishijima J, Hasegawa H, Endo S, Isozaki Y, Kimura Y, Matsuyama J, Kurokawa Y, Shimokawa T, Fujitani, Sato T
    • Organizer
      ESMO Asia Congress
    • Place of Presentation
      Singapore
    • Year and Date
      2015-12-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 競合リスクを伴う生存時間データに対するルール・アンサンブル法の開発2015

    • Author(s)
      下川敏雄
    • Organizer
      2015年度 統計関連学会 連合大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 成都市および近郊地域における観光地開発の現況:-中国における伝統的観光地の顧客ニーズ調査-2015

    • Author(s)
      劉 岩・万 可・ 李 力・下川敏雄・大山 勲
    • Organizer
      第17回 日本感性工学会大会
    • Place of Presentation
      文化学園大学 新都心キャンパス
    • Year and Date
      2015-09-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 中国の成都市および近郊地域における伝統的観光地の顧客に対するニーズに関する影響要因解析2015

    • Author(s)
      万 可・劉 岩・ 李 力・下川敏雄・大山 勲
    • Organizer
      日本計算機統計学会 第29回大会
    • Place of Presentation
      山梨県立図書館
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
  • [Book] 実践のための基礎統計学2016

    • Author(s)
      下川敏雄
    • Total Pages
      231
    • Publisher
      講談社
    • Related Report
      2016 Research-status Report
  • [Remarks] 和歌山県立医科大学 臨床研究センター ホームページ

    • URL

      http://waidai-csc.jp/datacenter/%e5%ae%9f%e7%b8%be%e5%a0%b1%e5%91%8a/349

    • Related Report
      2017 Research-status Report
  • [Remarks] 和歌山県立医科大学 臨床研究センター

    • URL

      http://waidai-csc.jp/datacenter/%e5%ae%9f%e7%b8%be%e5%a0%b1%e5%91%8a/349

    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2021-02-19  

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