| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In epidemiological studies, it is often necessary to determine the relationship between exposure levels and the risk of disease. Exposure levels are often available in intervals. Recently we proposed a procedure for assessing nonlinear associations between exposure levels and the risk of disease from a summarized grouped data using a restricted cubic spline model with 3 knots. We applied this procedure to perform a meta-analysis for the association between alcohol intake and the log RR of total mortality based on summarized data that was used in Di Castelnuovo et al (2009). We would demonstrate the shape of the estimated curves by the cubic spline model, and assess the differences between our results and those of Di Castelnuovo et al, in application of our procedure to epidemiological studies.
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