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Temporal information processing of sounds in the guinea-pig auditory cortex

Research Project

Project/Area Number 15K00234
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Perceptual information processing
Research InstitutionToyohashi University of Technology

Principal Investigator

HORIKAWA Junsei  豊橋技術科学大学, 工学(系)研究科(研究院), シニア研究員 (50114781)

Co-Investigator(Kenkyū-buntansha) 小島 久幸  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (00104539)
杉本 俊二  豊橋技術科学大学, 工学(系)研究科(研究院), 助教 (50422811)
細川 浩  琉球大学, 医学(系)研究科(研究院), 准教授 (80181501)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords聴覚皮質 / 音の時間的構造 / 時間逆転音 / 光計測 / 微小電極計測 / STRF(周波数時間応答野) / 条件付け / モルモット / 音の繰り返し間隔 / 時間非対称音 / 逆転音 / 反応選択制 / 抑制機構
Outline of Final Research Achievements

Temporal information of the sounds is an important cue for recognition of the sounds as well as the frequency information. However, the neuronal processing of the temporal information of sounds has not been well investigated. In this study, we aimed to investigate the neuronal processing of temporal information of sounds in the auditory cortex of guinea pigs, using an optical recording and the extracellar recording techniques. Using temporally asymmetric natural sounds (recorded footstep sounds, F) and their temporal-reversal (rF), and repetitive sounds of F with various intervals, guinea pigs were trained under the classical conditioning to these sounds with rewards. We found that guinea pigs could discriminate F from rF and the interval trained from untrained intervals. We also found that the neuronal activity of the auditory cortex was changed plastically after the training and that the change conformed to the behaviors of the guinea pigs after the training.

Academic Significance and Societal Importance of the Research Achievements

本研究は、音や音声言語の認識において重要な要因である音の時間的構造の検出に、聴覚皮質がどのように関わるかについて、動物実験を行って調べた研究である。その結果、動物も人と同様に音の時間的構造を検出すること、その検出には聴覚皮質が関わること、および、時間的構造を有する音に対する条件付け訓練により聴覚皮質ニューロンの反応特性が可塑的に変化することが明らかになった。このような研究は世界的に数が少ないこと、本研究は聴覚皮質における音の認識機構の解明に寄与するものであること、また、査読付き国際雑誌に掲載されたことから、学術的意義を有する。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Cortical Activation Patterns Evoked by Temporally Asymmetric Sounds and Their Modulation by Learning.2017

    • Author(s)
      Horikawa J, Ojima H.
    • Journal Title

      eNeuro.

      Volume: 4(2) Issue: 2 Pages: 1-19

    • DOI

      10.1523/eneuro.0241-16.2017

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 聴覚皮質における音の時間的側面の処理2018

    • Author(s)
      堀川順生
    • Organizer
      台19回音楽情報科学・第122回音声言語情報処理合同研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Salicylate-induced changes of the tonotopy map in the primary auditory cortex of guinea pigs observed by optical recording.2018

    • Author(s)
      Hosokawa Y, Kubota M, Sugimoto S, Horikawa J
    • Organizer
      日本生理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] サリチル酸過剰投与によるモルモット一次聴覚皮質の繰り返し音応答変化2018

    • Author(s)
      細川浩、杉本俊二、堀川順生
    • Organizer
      日本音響学会聴覚研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Analysis of temporal-information processing of sounds in the primary auditory cortex2016

    • Author(s)
      Atsushi Shibata, Satoshi Ohta, Shunji Sugimoto, Hisayuki Ojima and Junsei Horikawa
    • Organizer
      The 3rd Annual Meeting of the Society for Bioacoustics
    • Place of Presentation
      Tahara-city, Japan
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Distribution of neurons' spectortemporal receptive fields along the depth axis in the primary auditory cortex2016

    • Author(s)
      Satoshi Ohta, Nodoka Wakabayashi, Shunji Sugimoto and Junsei Horikawa
    • Organizer
      The 3rd Annual Meeting of the Society for Bioacoustics
    • Place of Presentation
      Tahara-city, Japan
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 時間非対称の自然音とその逆転音に対するモルモットAIニューロンの活動特性2016

    • Author(s)
      堀川順生, 柴田篤志, 太田諭, 杉本俊二, 小島久幸
    • Organizer
      日本音響学会聴覚研究会
    • Place of Presentation
      豊橋市
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Temporal pattern of AI activity changes after training to discriminate intervals of repetitive natural sounds in guinea pigs2016

    • Author(s)
      K. Hayashi, H. Ojima and J. Horikawa
    • Organizer
      ARO
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2016-02-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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