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Design of chronotheraputic strategy against tumorgenesis based on modeling of cell cycle interacting with circadian clock

Research Project

Project/Area Number 15K00394
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Life / Health / Medical informatics
Research InstitutionTohoku University

Principal Investigator

Nakao Mitsuyuki  東北大学, 情報科学研究科, 教授 (20172265)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords確率オートマトン / 代謝経路選択 / 胆汁酸 / 腸肝循環 / 肝臓ガン / 末梢時計 / 摂食リズム位相反転 / 核内受容体CAR / 解糖系 / 乳酸呼吸 / 嫌気性代謝 / 好気性代謝 / ガン時間治療 / 細胞死 / DNA修復
Outline of Final Research Achievements

It has been reported that tumorigenesis and progression increase significantly when the circadian rhythms are impaired. Therefore, the chronotherapy of cancer has naturally been conducted. In this study, we constructed an automaton model of normal and cancer cell proliferation under the control of the circadian clock, and simulated their metabolic selection and proliferation. This indicates that the growth of cancer can be suppressed through metabolic modification. Furthermore, we focused on the transition mechanism from bile acid (BA) concentration abnormality to liver tumorigenesis, and modeling of the control mechanism of BA recycling and production under circadian rhythm control. The modeling indicates that changes in temporal order of BA production/uptake and degradation/excretion could cause an abnormal increase in the hepatic BA concentration, which leads to tumorigenesis.

Academic Significance and Societal Importance of the Research Achievements

概日時計機構が障害されるとガンの発生率や進行が有意に高まることが知られているが、そのメカニズムは知られていない。本研究では、概日時計の制御を受ける細胞周期確率オートマトンモデルに代謝系を組込み、栄養環境や細胞内概日時計の周期に依存して代謝経路選択や増殖率が異なることを明らかにした。さらに、概日リズム制御下にある肝臓胆汁酸(BA)のリサイクル、産生の制御機構をモデル化し、BA濃度フィードバックシステムが概日時計の変調を受けることによって、生産/取込みと排出の時間的秩序を保ち、それが変容することで異常な濃度上昇が起こり、それがガン化へと至る可能性を示した。これらはガンの時間療法の最適化に役立つ。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (54 results)

All 2019 2018 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (44 results) (of which Int'l Joint Research: 8 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Relationship between Dynamics of Physiological Signals and Subjective Quality of Life and Its Lifestyle Dependency2019

    • Author(s)
      Ryota Amano, Akihiro Karashima, Ikuko Motoike, Norihiro Katayama, Kengo Kinoshita, Mitsuyuki Nakao
    • Journal Title

      Proceedings IEEE EMBC

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of the Retinotopic Map of an Awake Mouse Brain Based upon Intrinsic Optical Signal Imaging Considering the Ocular Position and Variation in Pupil Diameter2018

    • Author(s)
      外川 龍之介、奥畑 大悟、吉田 侑冬、中尾 光之、片山 統裕
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 56 Issue: 4 Pages: 157-163

    • DOI

      10.11239/jsmbe.56.157

    • NAID

      130007604778

    • ISSN
      1347-443X, 1881-4379
    • Year and Date
      2018-08-10
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics2018

    • Author(s)
      Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
    • Journal Title

      Physiological Measurement

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 睡眠時神経活動と睡眠-覚醒制御機構の数理モデル2017

    • Author(s)
      辛島彰洋,中尾光之
    • Journal Title

      医薬ジャーナル

      Volume: 53 Pages: 669-675

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Multidrug Cancer Chronotherapy Based on Cell Cycle Model under Influences of Circadian Clock2016

    • Author(s)
      Hiroshi Inokawa, Norihiro Katayama, Mitsuyuki Nakao
    • Journal Title

      Proc 38th Annual International Conference of the IEEE EMBS

      Volume: 38 Pages: 1439-1442

    • DOI

      10.1109/embc.2016.7590979

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Partial correlation-based functional connectivity analysis of the optical intrinsic signals of the mouse neocortex during resting state2016

    • Author(s)
      Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
    • Journal Title

      Proc 8th Intl Workshop Biosignal Interpret (BSI2016)

      Volume: 8 Pages: 53-56

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 独立成分分析を用いた内因性光信号の光源ノイズ除去アルゴリズムと評価2015

    • Author(s)
      吉田侑人,中川大輝,辛島彰洋,中尾光之,片山統裕
    • Journal Title

      生体医工学

      Volume: 53 Pages: 328-335

    • NAID

      130005155602

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduction of Light Source Noise from Optical Intrinsic Signals of Mouse Neocortex by using Independent Component Analysis2015

    • Author(s)
      Yuto Yoshida, Daiki Nakagawa, Akihiro Karashima, Mitsuyuki Nakao, Norihiro Katayama
    • Journal Title

      Proc. 37th Annual International Conference of the IEEE EMBS

      Volume: 37 Pages: 6277-6280

    • DOI

      10.1109/embc.2015.7319827

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Spatiotemporal dynamics and topology of spontaneous brain activity of the mouse neocortex measured by the intrinsic optical signal imaging2018

    • Author(s)
      Norihiro Katayama, Yuto Yoshida, Ryunosuke Togawa, Mitsuyuki Nakao
    • Organizer
      The 9th Congress of Asian Sleep Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantitative characterization of wrist movements during sleep in relation to self-rating sleep quality2018

    • Author(s)
      Siwalee Choilek, Ikuko N. Motoike, Toshihiro Uchibayashi, Akihiro Karashima, Norihiro Katayama, Mitsuyuki Nakao
    • Organizer
      The 9th Congress of Asian Sleep Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modeling of hepatic bile acid regulation under circadian clock influences in relation to carcinogenesis2018

    • Author(s)
      Yohei Morisaki, Norihiro Katayama, Mitsuyuki Nakao
    • Organizer
      Sapporo Symposium on Biological Rhythm
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The intrinsic optical signal of cerebral blood volume dynamics express the resting-state functional connectivity of the mouse brain2018

    • Author(s)
      Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
    • Organizer
      Tohoku U-NTU Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Health Index Formation based on Analysis of Accelerometer Information2018

    • Author(s)
      Siwalee Choilek, Norihiro Katayama, Mitsuyuki Nakao
    • Organizer
      International Kick-off Symposium of Graduate Program in Data Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 視覚刺激がマウスの歩行運動に及ぼす影響2018

    • Author(s)
      大﨑大輝,外川龍之介,和田みなみ,吉田侑冬,中尾光之,虫明元,片山統裕
    • Organizer
      電子情報通信学会ニューロコンピューティング研究会技術報告, NC2018-16
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活動量と生体信号変動ダイナミクスの相関関係とその睡眠―覚醒ライフスタイル依存性2018

    • Author(s)
      天野領太,辛島彰洋,元池育子,片山統裕,木下賢吾,中尾光之
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会技術報告, MBE2018-34
    • Related Report
      2018 Annual Research Report
  • [Presentation] メチマゾール誘発一過性甲状腺機能低下症マウスの行動試験と安静時脳機能結合の解析2018

    • Author(s)
      吉田侑冬,内田竜生,内田克哉,井樋慶一,中尾光之,片山統裕
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会技術報告, MBE2018-33
    • Related Report
      2018 Annual Research Report
  • [Presentation] Evaluation of the resting-state functional connectivity of the mouse brain by the intrinsic optical signal of cerebral blood volume2018

    • Author(s)
      Yuto Yoshida, Ryusei Uchida, Mitsuyuki Nakao, Norihiro Katayama
    • Organizer
      Proc. Life Engineering Symposium (LE2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Heart rate variability and respiration rate varaiability dynamics differentiated subjective sleep quality depending on selected life style2018

    • Author(s)
      Ryota Amano, Akihiro Karashima, Ikuko Motoike, Norihiro Katayama, Kengo Kinoshita, Mitsuyuki Nakao
    • Organizer
      Proc. JBMES 2018 (生体医工学シンポジウム)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 眠気に依存した聴覚の周波数特性の変化2018

    • Author(s)
      辛島彰洋,石塚隆太,伊藤智,関直哉,鈴木幸也,片山統裕,中尾光之
    • Organizer
      日本睡眠学会第43回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活動状態依存性に変化するHRV ダイナミクスと主観的睡眠評価2018

    • Author(s)
      天野領太,辛島彰洋,元池育子,片山統裕,木下賢吾,中尾光之
    • Organizer
      第57回日本生体医工学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Sleep-wake state-dependent synaptic plasticity in the hippocampus2017

    • Author(s)
      Akihiro Karashima,Yukiteru Masuda,Norihiro Katayama,Hiroshi Tsubokawa, Mitsuyuki Nakao
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Research-status Report
  • [Presentation] Correlation and temporal relationship between the mouse hippocampal theta activity and its locomotion speed2017

    • Author(s)
      Norihiro Katayama, Yushiro Nakazawa, Yoshihisa Machida, Mitsuyuki Nakao, Hajime Mushiake
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Research-status Report
  • [Presentation] 睡眠-覚醒状態に依存した海馬神経回路におけるシナプスホメオスタシス2017

    • Author(s)
      辛島彰洋,益田幸輝,片山統裕 ,坪川宏,中尾光之
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 睡眠のラット海馬CA1領域におけるカルシウム透過性AMPA受容体発現への影響2017

    • Author(s)
      益田幸輝,中村有孝,辛島彰洋,片山統裕,中尾光之
    • Organizer
      第94回日本生理学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] In vivo Integrative Optical Imaging 法によるマウス大脳皮質の細胞外拡散特性解析2017

    • Author(s)
      廣谷唯,田中健也,吉田侑冬,辛島彰洋,中尾光之,片山統裕
    • Organizer
      電子情報通信学会技術報告, MBE 47
    • Related Report
      2017 Research-status Report
  • [Presentation] Comparison between functional networks estimated by marginal and parital correlation analysis of the optical intrinsic signals of the mouse neocortex2017

    • Author(s)
      Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Research-status Report
  • [Presentation] マウス大脳皮質における緑色自家蛍光の時空間ダイナミクス血液量動態の偏相関解析に基づいた機能的ネットワークの睡眠・覚醒状態依存性解析2017

    • Author(s)
      吉田侑冬,中尾光之,片山統裕
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Integrative Optical Imaging法を用いたマウス大脳皮質拡散特性の計測と解析2017

    • Author(s)
      廣谷唯,中尾光之,片山統裕
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 経頭蓋フラビン蛍光イメージング法によるマウス大脳皮質徐波活動の伝播特性解析2017

    • Author(s)
      片山統裕 ,佐藤杏莉,田中健也,中尾光之
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 大脳皮質脳波の徐波に同期した聴覚刺激システムの開発2017

    • Author(s)
      Kenya Tanaka, Anri Sato, Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
    • Organizer
      第56回日本生体医工学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 視交叉上核の日長依存性同期ダイナミクスのネットワークモデル2016

    • Author(s)
      吉岡亜由美,中尾光之,片山統裕
    • Organizer
      電子情報通信学会技術報告 MBE 116
    • Place of Presentation
      東北大学電気通信研究所(仙台)
    • Year and Date
      2016-11-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 睡眠ー覚醒状態に依存した大脳皮質興奮性神経回路の再編成2016

    • Author(s)
      辛島彰洋,益田幸輝,中村有孝,片山統裕,中尾光之
    • Organizer
      Proc Life Engineering Symposium 2016
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Interhemispheric Asymmetry of Sleep EEG Following Skilled Reaching Task in Rats2016

    • Author(s)
      Akihiro Karashima,Ryo Tsukada,Yuka Anzai,Norihiro Katayama,Mitsuyuki Nakao
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 短時間の断眠によるAMPA型グルタミン酸受容体の料への影響2016

    • Author(s)
      益田幸輝, 中村有孝, 辛島彰洋, 片山統裕, 中尾光之
    • Organizer
      日本睡眠学会大41回定期学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 運動トレーニング後の部分断眠がその後の技能向上に及ぼす影響2016

    • Author(s)
      辛島彰洋, 塚田僚, 安齋友花, 片山統裕, 中尾光之
    • Organizer
      日本睡眠学会大41回定期学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Comparison of Dual and Single Frequency Checkerboard Stimulation Performances for SSVEP-based BCI Application2015

    • Author(s)
      Vincent Rynik, Akihiro Karashima, Norihiro Katayama, Mitsuyuki Nakao
    • Organizer
      日本生体医工学専門別研究会 生体信号計測・解釈研究会第53回研究会
    • Place of Presentation
      横浜
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
  • [Presentation] レバー操作行動学習のためのマウス用スパウトレバー装置の開発2015

    • Author(s)
      高橋優斗,片山統裕,吉田侑冬,辛島彰洋,中尾光之
    • Organizer
      信学技報, MBE-2015-62
    • Place of Presentation
      仙台
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 技能課題が睡眠時に観測される自発脳波に及ぼす影響2015

    • Author(s)
      塚田僚,辛島彰洋,安齋友花,片山統裕,中尾光之
    • Organizer
      信学技報, MBE2015-54
    • Place of Presentation
      仙台
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 概日リズム制御下にあるガン細胞集団に対する時間治療効果のシミュレーション2015

    • Author(s)
      井ノ川広,辛島彰洋,片山統裕,中尾光之
    • Organizer
      信学技報, MBE2015-61
    • Place of Presentation
      仙台
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス用スパウトレバー操作課題実験系の開発2015

    • Author(s)
      高橋優斗,片山統裕,吉田侑冬.中尾光之
    • Organizer
      生体医工学シンポジウム2015
    • Place of Presentation
      岡山
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 動物もバーチャルリアリティにリアルを感じるか?2015

    • Author(s)
      片山統裕,吉田侑冬,中尾光之
    • Organizer
      第25回インテリジェント・システム・シンポジウム(FAN2015)
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Estimation of functional brain map of mice based on optical intrinsic imaging and independent component analysis2015

    • Author(s)
      Yuto Yoshida, Norihiro Katayama, Daiki Nakagawa, Akihiro Karashima, Mitsuyuki Nakao
    • Organizer
      Proceedings of Life Engineering Symposium 2015
    • Place of Presentation
      飯塚
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Model-based evaluation of multidrug cancer chronotherapy2015

    • Author(s)
      Hiroshi Inokawa, Norihiro Katayama, Mitsuyuki Nakao
    • Organizer
      XIV European Biological Rhythms Society (EBRS) & IV World Congress of Chronobiology (WCC)
    • Place of Presentation
      Manchester, UK
    • Year and Date
      2015-08-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Velocity response-based modeling of photoperiod-dependent synchronization patterns of pacemaker cells in suprachiasmatic nucleus2015

    • Author(s)
      Mitsuyuki Nakao, Ayumi Yoshioka, Norihiro Katayama
    • Organizer
      XIV European Biological Rhythms Society (EBRS) & IV World Congress of Chronobiology (WCC)
    • Place of Presentation
      Manchester, UK
    • Year and Date
      2015-08-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Computer simulations of distance selective recruitment of myelinated nerve fibers in central nervous system by electrical stimulation2015

    • Author(s)
      Anri Sato, Norihiro Katayama, Ayako Ueno, Akihiro Karashima, Mitsuyuki Nakao
    • Organizer
      38th Ann Meet Japan Neurosci Soc (Neuroscience 2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Transcranial green-reflected-light macro imaging of spontaneous cortical activities in unanesthetized mice2015

    • Author(s)
      Yuto Yoshida, Norihiro Katayama, Daiki Nakagawa, Akihiro Karashima, Mitsuyuki Nakao
    • Organizer
      38th Ann Meet Japan Neurosci Soc (Neuroscience 2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Effect of somatosensory feedback on behavior of mouse in the virtual reality environment2015

    • Author(s)
      Norihiro Katayama, Toshio Araya, Yuto Yoshida, Akihiro Karashima, Mitsuyuki Nakao
    • Organizer
      38th Ann Meet Japan Neurosci Soc (Neuroscience 2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動技能課題直後に観測される使用依存的な睡眠時デルタ波パワーの増大2015

    • Author(s)
      塚田僚, 安齋友花, 辛島彰浩, 片山統裕, 中尾光之
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動技能課題後に観測される使用依存的なノンレム睡眠時徐波パワーの増大とその神経基盤2015

    • Author(s)
      片山統裕, 中川大輝, 吉田侑冬, 辛島彰洋
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 睡眠状態に依存した大脳皮質神経回路の再編成2015

    • Author(s)
      辛島彰洋, 稲田浩之, 片山統裕, 中尾光之
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 概日リズムによって制御された細胞増殖ダイナミクスに対するガン時間治療効果のシミュレーション2015

    • Author(s)
      井ノ川広,辛島彰洋,片山統裕,中尾光之
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 無麻酔下マウスにおける大脳皮質自発活動の内因性光イメージング解析2015

    • Author(s)
      吉田侑冬,片山統裕,中川大輝,辛島彰洋,中尾光之
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07
    • Related Report
      2015 Research-status Report
  • [Book] 睡眠覚醒の数理モデル 三島編「睡眠科学」2016

    • Author(s)
      中尾光之
    • Total Pages
      324
    • Publisher
      化学同人
    • Related Report
      2016 Research-status Report
  • [Book] Sleep models, in "Sleep Medicine: A Comprehensive Guide to Its Development, Clinical Milestones, and Advances in Treatment", S.Chokroverty, M.Billiard eds.2015

    • Author(s)
      Mitsuyuki Nakao, Akihiro Karashima, Norihiro Katayama
    • Total Pages
      584
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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