| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Transcription is a fundamental cellular process in which the RNA polymerase enzymes play a central role. In eukaryotes, RNA polymerase II (RNAPII) is responsible for this process, and genome-wide studies show that transcription by RNAPII is dynamically regulated. We constructed a mathematical model to reproduce cell experiment data and conducted a study to enable prediction of transcription phenomena under conditions impossible in cell experiments.
In this research, we further advance such prediction simulation by using topological geometry for fundamental investigation of diseases closer to deeper transcriptional mechanism change. Furthermore, by conducting computer simulations of transcription at one cell level, not only the average analysis of cell populations so far but also comparison with cell experiments in single cell analysis. We also unveiled unique proprietary mechanisms of cell-specific transcription.
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