| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We have developed methodologies and tools for analyzing Next Generation Sequencing data sets from T-cell or B-cell receptors that characterize diversities of those immune cells. The tools are accurate and efficient for analyzing vast amount of data sets. By applying the tools to data sets from various diseases, e.g., cancers, Crohn’s disease, and GVHD after hematopoietic stem cell transplantations, we succeeded to extract novel information representing relationships between those diseases and immune environments. We also could find new exon candidates in those receptor sequences. Furthermore, we proceeded with developments of dynamic models to estimate and predict variations of structure of immune-cell groups from time-course data sets.
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