Developments of methods for T-cell receptor sequence data analysis and understanding of diversities in the immune cells
Project/Area Number |
15K00399
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Life / Health / Medical informatics
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Research Institution | The University of Tokyo |
Principal Investigator |
Yamaguchi Rui 東京大学, 医科学研究所, 准教授 (90380675)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 免疫細胞シークエンスデータ解析 / 免疫細胞受容体レパトア解析 / T細胞受容体 / B細胞受容体 / バイオインフォマティクス / 免疫細胞集団シークエンス / 適応免疫 / 免疫細胞集団シークエンスデータ情報処理分野 |
Outline of Final Research Achievements |
We have developed methodologies and tools for analyzing Next Generation Sequencing data sets from T-cell or B-cell receptors that characterize diversities of those immune cells. The tools are accurate and efficient for analyzing vast amount of data sets. By applying the tools to data sets from various diseases, e.g., cancers, Crohn’s disease, and GVHD after hematopoietic stem cell transplantations, we succeeded to extract novel information representing relationships between those diseases and immune environments. We also could find new exon candidates in those receptor sequences. Furthermore, we proceeded with developments of dynamic models to estimate and predict variations of structure of immune-cell groups from time-course data sets.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Characterization of T cell repertoire in tumor tissues and blood in advanced colorectal cancers through deep T cell receptor sequencing2016
Author(s)
Tamura K, Hazama S, Yamaguchi R, Imoto S, Takenouchi H, Inoue Y, Kanekiyo S, Shindo Y, Satoru Miyano S, Nakamura Y, Kiyotani K
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Journal Title
Oncology Letters
Volume: 印刷中
Issue: 6
Pages: 3643-3649
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients2015
Author(s)
Yew PY, Alachkar H, Yamaguchi R, Kiyotani K, Fang H, Yap KL, Liu HT, Wickrema A, Artz A, van Besien K, Imoto S, Miyano S, Bishop MR, Stock W, Nakamura Y
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Journal Title
Bone Marrow Transplantation
Volume: 50
Issue: 9
Pages: 1227-1234
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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