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Bifurcation analysis of cardiac conduction systems using heterogeneous computing

Research Project

Project/Area Number 15K00405
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Life / Health / Medical informatics
Research InstitutionKagawa University

Principal Investigator

Kitajima Hiroyuki  香川大学, 創造工学部, 教授 (90314905)

Research Collaborator YAZAWA Toru  
HORIKAWA Yo  
FUJIMOTO Kenichi  
IOKA Eri  
KATO Kaiji  
SHIMADA Shogo  
TARUMOTO Tomoya  
TAKAHASHI Ai  
ABE Akatsuki  
OGOSHI Kazuto  
ITO Yuichiro  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分岐 / 心臓数理モデル / 交互脈 / 早期後脱分極 / FPGA / OpenCL / システムバイオロジー / 力学系
Outline of Final Research Achievements

In this study, we developed effective algorithms using heterogeneous computing. We applied it to mathematical cardiac models and obtained that the mechanism of generating alternans that is a sign of cardiac arrest. We reproduced the dying process of crustaceans on a computer and clarified that the alternans occurs through abnormalities of the conductivity of the calcium ionic current, and it triggers cardiac arrest.

Academic Significance and Societal Importance of the Research Achievements

CPU以外のデバイスを効率的に使うことにより,CPU単体で計算するよりは最大で約30倍の高速化および電力消費の97.1%の削減が達成された.その手法を心臓数理モデルの解析に適用することにより,心停止に至るプロセスをコンピュータ上で再現し,突然死に繋がる不整脈が起こる原因の一端を解明した.また,その数値解析において,従来では知られていない新しい数学的な現象も発見することができた.

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2019 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) (of which Int'l Joint Research: 13 results)

  • [Journal Article] Fold-Pitchfork Bifurcation, Arnold Tongues and Multiple Chaotic Attractors in a Minimal Network of Three Sigmoidal Neurons2018

    • Author(s)
      Horikawa Yo、Kitajima Hiroyuki、Matsushita Haruna
    • Journal Title

      International Journal of Bifurcation and Chaos

      Volume: 28 Issue: 10 Pages: 1850123-1850123

    • DOI

      10.1142/s0218127418501237

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Health wellness monitoring using the scaling exponent: a heartbeat interval time series analysis2018

    • Author(s)
      T. Yazawa and H. Kitajima
    • Journal Title

      Journal of Systemics, Cybernetics and Informatics

      Volume: 16 Pages: 74-80

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of nonlinear analysis tools on FPGA2017

    • Author(s)
      S. Shimada and H. Kitajima
    • Journal Title

      Nonlinear Theory and Its Applications, IEICE

      Volume: 8 Issue: 2 Pages: 173-179

    • DOI

      10.1587/nolta.8.173

    • NAID

      130005530421

    • ISSN
      2185-4106
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation mechanism of alternans in Luo-Rudy model2016

    • Author(s)
      H. Kitajima, E. Ioka and T. Yazawa
    • Journal Title

      International Journal of Bifurcation and Chaos

      Volume: 26 Issue: 05 Pages: 1650075-1650075

    • DOI

      10.1142/s0218127416500759

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Firing patterns in coupled systems of inhibitory neurons2016

    • Author(s)
      K. Kato and H. Kitajima
    • Journal Title

      Journal of Signal Processing

      Volume: 20 Pages: 83-90

    • NAID

      130005153247

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Robust bifurcation analysis based on optimization of degree of stability2015

    • Author(s)
      H. Kitajima, T. Yoshinaga, J. Imura and K. Aihara
    • Journal Title

      Int. J. of Innovative Computing Information and Control

      Volume: 11 Pages: 153-162

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Bifurcations related to transient EAD in a mathematical cardiac model2019

    • Author(s)
      Y. Ito, H. Kitajima and T. Yazawa
    • Organizer
      信号処理学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation mechanism of transient EAD in a mathematical ventricular model2019

    • Author(s)
      Y. Ito, H. Kitajima and T. Yazawa
    • Organizer
      日本生理学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alternans in a Mathematical Crustacean Cardiac Model2019

    • Author(s)
      H. Kitajima and T. Yazawa
    • Organizer
      日本生理学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reconstruction of CT Images by Iterative Least Squares Methods with Nonnegative Constraint2018

    • Author(s)
      H. Kohno, Y. Tanji, K. Fujimoto, H. Kitajima, Yo Horikawa and N. Takahashi
    • Organizer
      IEICE
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 甲殻類の心臓数理モデルにみられる分2018

    • Author(s)
      安部暁,北島博之,矢澤徹
    • Organizer
      電子情報通信学会
    • Related Report
      2017 Research-status Report
  • [Presentation] CNNを用いた心拍データの異常検出2018

    • Author(s)
      尾越和人,北島博之
    • Organizer
      電子情報通信学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Detecting bifurcations from time series data2016

    • Author(s)
      K. Ogoshi, H. Kitajima and T. Yazawa
    • Organizer
      International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      湯河原
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bifurcation analysis for early afterdepolarization in Shannon model2016

    • Author(s)
      A. Takahashi, H. Kitajima and T. Yazawa
    • Organizer
      International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      湯河原
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Alternans in a Crustacean Cardiac Model2016

    • Author(s)
      A. Abe, H. Kitajima and T. Yazawa
    • Organizer
      International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      湯河原
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discordant alternans and codimension-three bifurcations in coupled Luo-Rudy models2016

    • Author(s)
      H. Kitajima and T. Yazawa
    • Organizer
      International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      湯河原
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Alternans generation crustacean heart model: a simulation - electrophysiology study2016

    • Author(s)
      T. Yazawa and H. Kitajima
    • Organizer
      International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      湯河原
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心臓細胞モデルの結合系における同期2016

    • Author(s)
      津山裕亮,北島博之
    • Organizer
      電子情報通信学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Bifurcations related to QT prolongation in a mathematical cardiac model2016

    • Author(s)
      A. Takahashi, H. Kitajima and T. Yazawa
    • Organizer
      International Workshop on Nonlinear Circuits and Signal Processing
    • Place of Presentation
      Honolulu
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Discrete-Time Oscillator Network for Extracting Image Fragments2016

    • Author(s)
      K. Fujimoto, H. Murai, H. Kitajima and H. He
    • Organizer
      Bangkok International Conference on Innovative Research in Engineering and Technology
    • Place of Presentation
      Bangkok
    • Year and Date
      2016-01-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of Nonlinear Analysis Tools on FPGA2015

    • Author(s)
      S. Shimada and H. Kitajima
    • Organizer
      International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      Hong Kong
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bifurcations in a System of Inhibitory Coupled Neurons2015

    • Author(s)
      K. Kato, K. Fujimoto and H. Kitajima
    • Organizer
      International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      Hong Kong
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] FPGAを用いた連続系の分岐図の作成2015

    • Author(s)
      嶋田匠吾,北島博之
    • Organizer
      電子情報通信学会
    • Place of Presentation
      高松
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 心臓数理モデルにおいてイオン電流の変化によりみられるQT延長2015

    • Author(s)
      高橋愛,北島博之,矢澤徹
    • Organizer
      電子情報通信学会
    • Place of Presentation
      高松
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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