Mathematical Understanding of lnformation Processing Mechanism in the Brain by lnteraction of Glial and Neuronal Networks
Project/Area Number |
15K00417
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Life / Health / Medical informatics
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Research Institution | The Institute of Statistical Mathematics |
Principal Investigator |
Tamura Yoshiyasu 統計数理研究所, データ科学研究系, 教授 (60150033)
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Co-Investigator(Kenkyū-buntansha) |
染谷 博司 東海大学, 情報理工学部, 准教授 (00333518)
越久 仁敬 兵庫医科大学, 医学部, 教授 (20252512)
岡田 泰昌 独立行政法人国立病院機構村山医療センター(臨床研究部), 電気生理学研究室, 室長 (80160688)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | アストロサイト / カルシウムイメージング / 呼吸リズム / ニューロン / グリア細胞 / カルシームイメージング / 低酸素呼吸応答 |
Outline of Final Research Achievements |
Astrocytes in the brain stem have an important role in respiratory rhythm formation in coordination with neurons. It was found that astrocytes play an important role in hypoxic respiratory response mechanism as hypoxic sensors in the brain. We developed a simulation model by coupling a neuronal network model and an astrocytic oscillator model. We attempted to reveal roles of astrocytes in respiratory rhythm formation by simulations.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] Activated astrocytes induce persistence of post-stress blood pressure elevation2017
Author(s)
Y Hasebe, S Sugama, K Takeda, K Koizumi, S Yokota, I Fukushi, M Hoshiai, Y Kakinuma, M Pokorski, J Horiuchi, K Sugita, Y Okada
Organizer
International Society for Autonomic Neuroscience Meeting (ISAN 2017)
Related Report
Int'l Joint Research
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[Presentation] A novel model of respiratory rhythm generation: a mechanism by interaction of intrinsically oscillating astrocytes and neurons2015
Author(s)
Okada Y, Oku Y, Sasaki T, Vivar C, Yokota S, Takeda K, Fukushi I, Yazawa I, Someya H, Tamura Y
Organizer
Neuroscience 2015, 45th Society for Neuroscience Annual Meeting
Place of Presentation
Chicago, USA
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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