Regulation of DNA repair pathway choice by early DNA damage response factors.
| Project/Area Number |
15K00536
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Tohoku Medical and Pharmaceutical University (2016-2017)
Kyoto University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | DNA修復 / 放射線 / DNA二重鎖切断 / NBS1 |
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| Outline of Final Research Achievements |
NBS1 and ATM are DNA damage response factors that are involved in an early step of the cascade. Molecular analysis showed that NBS1 has a novel function to enhance a particular pathway of the ATM signaling and the DSB repair system. Our results suggest that NBS1 might regulate DSB repair via pinpoint control of ATM signaling pathway.
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Report
(4 results)
Research Products
(7 results)
