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Regulation of DNA repair pathway choice by early DNA damage response factors.

Research Project

Project/Area Number 15K00536
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionTohoku Medical and Pharmaceutical University (2016-2017)
Kyoto University (2015)

Principal Investigator

YANAGIHARA Akihiro  東北医科薬科大学, 医学部, 助教 (70423051)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsDNA修復 / 放射線 / DNA二重鎖切断 / NBS1
Outline of Final Research Achievements

NBS1 and ATM are DNA damage response factors that are involved in an early step of the cascade. Molecular analysis showed that NBS1 has a novel function to enhance a particular pathway of the ATM signaling and the DSB repair system. Our results suggest that NBS1 might regulate DSB repair via pinpoint control of ATM signaling pathway.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Book (2 results)

  • [Journal Article] RNF20-SNF2H pathway of chromatin relaxation in DNA double-strand break repair2015

    • Author(s)
      Akihiro Kato, Kenshi Komatsu
    • Journal Title

      Genes

      Volume: 6 Issue: 3 Pages: 592-606

    • DOI

      10.3390/genes6030592

    • NAID

      120005756286

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] NBS1 の新規 C 末端ドメインは NHEJ の亢進に関与する2017

    • Author(s)
      加藤晃弘、柳原啓見、小松賢志
    • Organizer
      第34回染色体ワークショップ・第15回核ダイナミクス研究会
    • Place of Presentation
      かずさアカデミアホール(千葉県・木更津市)
    • Year and Date
      2017-01-12
    • Related Report
      2016 Research-status Report
  • [Presentation] NBS1 controls homologous recombination and non-homologous end joining in different ways.2016

    • Author(s)
      Akihiro Kato, Hiromi Yanagihara, and Kenshi Komatsu
    • Organizer
      The 10th International 3R Symposium
    • Place of Presentation
      ホテル一畑(島根県・松江市)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of the novel C-terminus domain of NBS1.2015

    • Author(s)
      Akihiro Kato and Kenshi Komatsu
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Analysis of the novel functional domain of NBS1.2015

    • Author(s)
      Akihiro Kato, Hiromi Yanagihara and Kenshi Komatsu
    • Organizer
      ICRR2015
    • Place of Presentation
      京都
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 光と生命の事典2016

    • Author(s)
      加藤晃弘、秋山(張)秋梅、安倍学、蟻川謙太郎、安東宏徳、飯郷雅之、飯野盛利、池内昌彦、池田憲昭、池田啓、池畑広伸、井澤毅、石川大太郎、石川満、石田斉、石塚徹、井上圭一、井上幸次、伊吹裕子、今井啓雄
    • Total Pages
      435
    • Publisher
      朝倉書店
    • Related Report
      2015 Research-status Report
  • [Book] 日本臨牀 73/増刊6 家族性腫瘍学2015

    • Author(s)
      加藤晃弘、柳原啓見、小松賢志、石岡千加史、冨田尚裕、野水整、吉田輝彦、宇都宮譲二、福嶋義光、山内泰子、水谷修紀、谷内江昭宏、東元健、福岡みずき、玉井裕也、田中潔、向井徳男、池田史圭、小林宏寿、芦田敦子
    • Total Pages
      607
    • Publisher
      日本臨牀社
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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