Regulation of DNA repair pathway choice by early DNA damage response factors.

• Project/Area Number: 15K00536
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Tohoku Medical and Pharmaceutical University (2016-2017); Kyoto University (2015)
• Principal Investigator: YANAGIHARA Akihiro 東北医科薬科大学, 医学部, 助教 (70423051)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: DNA修復 / 放射線 / DNA二重鎖切断 / NBS1

Outline of Final Research Achievements

NBS1 and ATM are DNA damage response factors that are involved in an early step of the cascade. Molecular analysis showed that NBS1 has a novel function to enhance a particular pathway of the ATM signaling and the DSB repair system. Our results suggest that NBS1 might regulate DSB repair via pinpoint control of ATM signaling pathway.

Research Products

• [Journal Article] RNF20-SNF2H pathway of chromatin relaxation in DNA double-strand break repair (2015)
  • Author(s): Akihiro Kato, Kenshi Komatsu
  • Journal Title: Genes Volume: 6 Issue: 3 Pages: 592-606
  • DOI: 10.3390/genes6030592
  • NAID: 120005756286
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] NBS1 の新規 C 末端ドメインは NHEJ の亢進に関与する (2017)
  • Author(s): 加藤晃弘、柳原啓見、小松賢志
  • Organizer: 第34回染色体ワークショップ・第15回核ダイナミクス研究会
  • Place of Presentation: かずさアカデミアホール（千葉県・木更津市）
  • Year and Date: 2017-01-12
• [Presentation] NBS1 controls homologous recombination and non-homologous end joining in different ways. (2016)
  • Author(s): Akihiro Kato, Hiromi Yanagihara, and Kenshi Komatsu
  • Organizer: The 10th International 3R Symposium
  • Place of Presentation: ホテル一畑（島根県・松江市）
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Functional analysis of the novel C-terminus domain of NBS1. (2015)
  • Author(s): Akihiro Kato and Kenshi Komatsu
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Analysis of the novel functional domain of NBS1. (2015)
  • Author(s): Akihiro Kato, Hiromi Yanagihara and Kenshi Komatsu
  • Organizer: ICRR2015
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Book] 光と生命の事典 (2016)
  • Author(s): 加藤晃弘、秋山（張）秋梅、安倍学、蟻川謙太郎、安東宏徳、飯郷雅之、飯野盛利、池内昌彦、池田憲昭、池田啓、池畑広伸、井澤毅、石川大太郎、石川満、石田斉、石塚徹、井上圭一、井上幸次、伊吹裕子、今井啓雄
  • Total Pages: 435
  • Publisher: 朝倉書店
• [Book] 日本臨牀 73/増刊6 家族性腫瘍学 (2015)
  • Author(s): 加藤晃弘、柳原啓見、小松賢志、石岡千加史、冨田尚裕、野水整、吉田輝彦、宇都宮譲二、福嶋義光、山内泰子、水谷修紀、谷内江昭宏、東元健、福岡みずき、玉井裕也、田中潔、向井徳男、池田史圭、小林宏寿、芦田敦子
  • Total Pages: 607
  • Publisher: 日本臨牀社