| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have recently found a novel tamoxifen-specific receptor in the endoplasmic reticulum membrane or nuclear envelope in various cells. The purpose of the present study is to identify this tamoxifen receptor substance in a breast cancer cell and also to develop the new anti-estrogen with its inability to bind to such a tamoxifen-receptor. Despite our efforts, we failed in the isolation of any receptor substances present on endoplasmic reticulum membrane this time. On the other hand, we succeeded in identifying several different kinds of candidate receptor proteins, the siRNA knockdown of which attenuated significantly the maximum binding of tamoxifen. Furthermore, we achieved in the design-synthesis of a novel series of compounds that strongly bind to the estrogen receptor, but not to the tamoxifen receptor.
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