Elucidation of the molecular mechanism of anti-fouling effects organotin compounds focused on nuclear receptors
| Project/Area Number |
15K00560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Suzuka University of Medical Science (2016-2017)
Kinjo Gakuin University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
永瀬 久光 岐阜薬科大学, 薬学部, 教授 (40141395)
中西 剛 岐阜薬科大学, 薬学部, 准教授 (50303988)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 有機スズ化合物 / PPARγ / 核内受容体 / クロアシカサガイ |
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| Outline of Final Research Achievements |
We cloned a short fragment of the PPAR gamma LBD from Leucoraja erinacea, Petromyzon marinus and Patella depressa (LePPARγ, PmPPARγ and PdPPARγ) and investigated the ligand activity of Rosiglitazone, TBT and TPT on the LePPARγ, PmPPARγ and PdPPARγ.Treatment with rosiglitazone, TBT and TPT had no effects on the PdPPARγ. Although the agonist activity of Rosiglitazone for LePRARγ and PmPPARγ is lower than that for human PPARγ, the agonist activity of TBT and TPT for LePRARγ and PmPPARγ is higher than that for human PPARγ. The results suggest that the effects of TBT and TPT via PPARγ in aquatic species were higher than that in human.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Germline recombination in a novel Cre transgenic line, Prl3b1-cre mouse.2016
Author(s)
Al-Soudy AS, Hiromori Y, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki Hi, Yoshiki A, Nagase H, Nakanishi T, Takahashi S, Oishi H, Sugiyama F.
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Journal Title
Genesis.
Volume: 54(7)
Issue: 7
Pages: 389-97
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds.2015
Author(s)
Harada, S., Hiromori, Y., Nakamura, S., Kawahara, K., Fukakusa, S., Maruno, T., Noda, M., Uchiyama, S., Fukui, K., Nishikawa, J., Nagase, H., Kobayashi, Y., Yoshida, T., Ohkubo, T., Nakanishi, T.,
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Journal Title
Sci. Rep.
Volume: 5:8520
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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