| Project/Area Number |
15K00786
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kochi University |
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Principal Investigator |
Miyamura Mitsuhiko 高知大学, 教育研究部医療学系臨床医学部門, 教授 (70464378)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Keywords | 嚥下 / サブスタンスP / 経皮吸収 / 嚥下機能 |
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| Outline of Final Research Achievements |
To address the needs of an aging society, we have tried to develop a percutaneous absorptive form of swallowing improving agents; 10% ginger-formulated white petrolatum ointment and 10% ginger-formulated polyethylene glycol ointment. In the ginger-formulated white petrolatum ointment, the cumulative skin permeation amount of 6-gingerol increased in a time-dependent manner in the skin permeation test. On the other hand, penetration of 6-gingerol could not be detected with ginger-formulated polyethylene glycol ointment. Thus, it was suggested that an oleaginous base was suitable for ginger-formulated ointments. In clinical trials using 10% ginger-formulated white petrolatum ointment, the amount of SP in saliva, which is considered as a biomarker of swallowing function increased from 1 hour after ointment application. Judging from the half-life, it was suggested that the swallowing function improving effect lasted several hours.
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