Development of percutaneous absorptive swallowing improving agent corresponding to aging society

• Project/Area Number: 15K00786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kochi University
• Principal Investigator: Miyamura Mitsuhiko 高知大学, 教育研究部医療学系臨床医学部門, 教授 (70464378)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
• Keywords: 嚥下 / サブスタンスP / 経皮吸収 / 嚥下機能

Outline of Final Research Achievements

To address the needs of an aging society, we have tried to develop a percutaneous absorptive form of swallowing improving agents; 10% ginger-formulated white petrolatum ointment and 10% ginger-formulated polyethylene glycol ointment. In the ginger-formulated white petrolatum ointment, the cumulative skin permeation amount of 6-gingerol increased in a time-dependent manner in the skin permeation test. On the other hand, penetration of 6-gingerol could not be detected with ginger-formulated polyethylene glycol ointment. Thus, it was suggested that an oleaginous base was suitable for ginger-formulated ointments. In clinical trials using 10% ginger-formulated white petrolatum ointment, the amount of SP in saliva, which is considered as a biomarker of swallowing function increased from 1 hour after ointment application. Judging from the half-life, it was suggested that the swallowing function improving effect lasted several hours.

Research Products

• [Presentation] 高知県産ショウガ含有経皮吸収型製剤における口腔内TRPV1発現量 ―口腔内刺激型製剤との比較― (2015)
  • Author(s): 飯塚美知郎, 平田歩, 阿部譲朗, 八木祐助, 仲井めぐみ, 白石久, 常風興平, 横田淳子, 宮村充彦.
  • Organizer: 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 高知市文化プラザかるぽーと(高知市)
  • Year and Date: 2015-10-31
• [Presentation] 嚥下機能改善を目的とした経皮吸収型製剤の開発とその評価 (2015)
  • Author(s): 平田 歩, 藤野真歩, 白川直樹, 石田七生, 船戸裕樹, 阿部譲朗, 飯塚美知郎, 白石 久, 常風興平, 横田淳子, 宮村充彦
  • Organizer: 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 高知市文化プラザかるぽーと（高知市）
  • Year and Date: 2015-10-31