Assessment of high functionality of Dioscorea japonica and development of dysphagia diet using the yam

• Project/Area Number: 15K00792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Okayama Prefectural University
• Principal Investigator: Yamamoto Toshiko 岡山県立大学, 保健福祉学部, 教授 (60301313)
• Co-Investigator(Renkei-kenkyūsha): ITO Hideyuki 岡山県立大学, 保健福祉学部, 教授 (70253002) ; MATSUURA Eiji 岡山大学, 大学院・医師薬学総合研究科, 教授 (20181688) ; YAMAMOTO Kei 徳島大学, 生物資源産業学部, 准教授 (30304504) ; KIMOTO Masumi 岡山大学, 大学院・医師薬学総合研究科, 教授 (40108866)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: プロスタグランジンE2 / 慢性炎症 / 食品機能性 / 自然薯 / 嚥下調整食 / 嚥下食 / 慢性炎症予防 / シクロオキシゲナーゼ－２ / プロスタグランジンE合成酵素 / テクスチャー解析 / ジオスゲニン / 抗炎症作用 / 脂質メディエーター / テクスチャー / レオロジー

Outline of Final Research Achievements

Dioscorea japonica native to Japan suppresses COX-2 and mPGES-1 which are dominant enzyme to hyperproduce PGE2 involved in inflammation, carcinogenesis and so on. One of the candidate substances was found as phytosterol diosgenin. Diosgenin suppressed the enzymes in A549 cells through interactions with glucocorticoid receptor. In the rheological analyses 20-30% solution and 10% solution of Dioscorea japonica were taken as a true polymer and a dilute polymer, respectively. The viscoelastic parameters indicated suitable for food thickener. In Texture Profile Analysis on the basis of the standard specified by Ministry of Health, Labour and Welfare (level I-III for dysphagia diet), 30% solution of Dioscorea japonica powder had level II of all parameters, hardness, aggregability and adherability in the standard specified. These results suggested the ability of Dioscorea japonica for the development of dysphagia diet.

Research Products

• [Journal Article] Preventive effect of <i>Dioscorea japonica</i> on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E₂ synthetic pathway (2018)
  • Author(s): Tsukayama I, Toda K, Takeda Y, Mega T, Tanaka M, Kawakami Y, Takahashi Y, Kimoto M, Yamamoto K, Miki Y, Murakami M, Suzuki-Yamamoto T.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 62 Issue: 2 Pages: 139-147
  • DOI: 10.3164/jcbn.17-54
  • NAID: 130006407477
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ウシ生乳中リポカリン型プロスタグランジンD合成酵素の精製と酵素学的性質ならびに乳房炎のバイオマーカーとしての検討． (2017)
  • Author(s): 山本登志子，川井恵梨佳，田中充樹，長崎祐樹，戸田圭祐，川上祐生，高橋吉孝，木本眞順美，山本圭，村上誠．
  • Journal Title: 脂質生化学研究 Volume: 59 Pages: 26-28
• [Journal Article] 抗ロイコトリエンC4単鎖抗体の変異体における抗原結合特異性の変化． (2017)
  • Author(s): 川上祐生，金山友紀，新庄望良野，森香子，神崎圭太，山本登志子，菅原光明，齊野廣道，宮野雅司，山本尚三，高橋吉孝．
  • Journal Title: 脂質生化学研究 Volume: 59 Pages: 23-25
• [Journal Article] 嚥下調整食機能評価への嚥下音及び筋電図の応用． (2017)
  • Author(s): 中村孝文、田中充樹、落合優水、山本登志子．
  • Journal Title: 第32回リハ工学カンファレンス講演論文集 Volume: 1 Pages: 261-262
• [Journal Article] Study of preservation method of Dioscorea japonica and development of recipes utilizing the high functionality (2016)
  • Author(s): 目賀拓斗，田中小百合，津嘉山泉，大本安梨紗，田中充樹，戸田圭祐，川井恵梨佳，吉尾壯兒，木本眞順美，山本登志子.
  • Journal Title: 岡山県立大学保健福祉学部紀要 Volume: 22 Pages: 39-46
  • DOI: 10.15009/00001296
  • NAID: 120005714085
  • URL: https://oka-pu.repo.nii.ac.jp/records/1311
  • Year and Date: 2016-03-12
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rheological analysis of Dioscorea japonica to dysphagia diet development for the elderly (2016)
  • Author(s): 山本登志子，野村奈央，山本沙也加，田中充樹，目賀拓斗，津嘉山泉，戸田圭祐，川井恵梨佳，大野智子，木本眞順美．
  • Journal Title: 岡山県立大学保健福祉学部紀要 Volume: 22 Pages: 47-56
  • DOI: 10.15009/00001297
  • NAID: 120005714086
  • URL: https://oka-pu.repo.nii.ac.jp/records/1312
  • Year and Date: 2016-03-12
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Y54(L)W mutation of anti-leukotriene C4 single-chain antibody increases affinity to leukotriene E4 (2016)
  • Author(s): Yuki Kawakami, Mai Kinoshita, Yoshiko Mori, Shuji Okochi, Shiori Hirano, Ichika Shimoda, Keita Kanzaki, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Mitsuaki Sugahara, Tetsuya Hori, Hiromichi Saino, Masashi Miyano, Shozo Yamamoto, Yoshitaka Takahashi.
  • Journal Title: J. Biochem. Volume: 161 Issue: 1 Pages: 79-86
  • DOI: 10.1093/jb/mvw055
  • Peer Reviewed / Open Access
• [Journal Article] 岡山県産自然薯の新規食品機能性の探索とその高機能性をいかした嚥下食の開発． (2016)
  • Author(s): 山本登志子，津嘉山泉，田中充樹，戸田圭祐，目賀拓斗，中村孝文，木本眞順美.
  • Journal Title: 山陽技術雑誌 Volume: 63
• [Journal Article] 脂質メディエーター合成系をターゲットとした抗炎症・高腫瘍効果を有する食品機能性の探索． (2015)
  • Author(s): 山本 登志子，津嘉山 泉，武田 泰典，目賀 拓斗，戸田 圭祐，田中 充樹．
  • Journal Title: アサヒグループ学術振興財団 研究紀要 Volume: 27 Pages: 7-15
  • Open Access
• [Presentation] Lipocalin-type prostaglandin D synthase as a potential biomarker of bovine mastitis (2018)
  • Author(s): Yuki Nagasaki, Erika Kawai, Mitsuki Tanaka, Keisuke Toda, Izumi Tsukayama, Yuki Kawakami, Yoshitaka Takahashi, Masumi Kimoto, Yuka Okazaki, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto
  • Organizer: 59th International Conference on Bioscience of Lipid (ICBL)
  • Int'l Joint Research
• [Presentation] Diosgenin suppresses COX-2 and mPGES-1 mediated with glucocrticoid receptor and improves LPS-induced liver injury in mice (2018)
  • Author(s): Izumi Tsukayama, Nana Hojo, Takuto Mega, Keisuke Toda, Yuka Konoike, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto
  • Organizer: 59th International Conference on Bioscience of Lipid (ICBL)
  • Int'l Joint Research
• [Presentation] 乾癬モデルマウスにおける赤米ポリフェノールの抗炎症効果. (2017)
  • Author(s): 戸田圭祐、津嘉山泉、北條奈々、伊東秀之、我如古菜月、川上祐生、高橋吉孝、山本登志子.
  • Organizer: 日本農芸化学会2017
  • Place of Presentation: 京都
  • Year and Date: 2017-03-17
• [Presentation] ウシ生乳中リポカリン型プロスタグランジンD合成酵素の精製と酵素学的性質ならびに乳房炎のバイオマーカーとしての検討. (2017)
  • Author(s): 長崎 祐樹, 川井 恵梨佳, 田中 充樹, 戸田 圭祐, 川上 祐生, 高橋 吉孝, 木本 眞順美, 三木 寿美, 山本 圭, 村上 誠, 山本 登志子.
  • Organizer: 2017年度生命化学系学会合同年次大会，ConBio2017
• [Presentation] 赤米プロアントシアニジンによるプロスタグランジンE2産生抑制効果. (2017)
  • Author(s): 戸田圭祐，長崎祐樹，津嘉山泉，田中将夢，川井恵梨佳，我如古菜月，伊東秀之，川上祐生，高橋吉孝，三木寿美，山本圭，村上誠，山本登志子.
  • Organizer: 2017年度生命化学系学会合同年次大会，ConBio2017
• [Presentation] ジオスゲニンによるプロスタグランジンE2合成系酵素の発現抑制とLPS刺激マウス肝臓における免疫組織化学的解析 (2017)
  • Author(s): 北條奈々，目賀拓斗，戸田圭祐，川上祐生，高橋吉孝，山本登志子
  • Organizer: 第50回日本栄養・食糧学会 中国・四国支部大会
• [Presentation] ナツメグ抽出物およびその含有成分の5-リポキシゲナーゼ抑制効果. (2017)
  • Author(s): 川上 祐生、森 香子、岡本 憲典、神崎 圭太、山本 登志子、伊東 秀之、高橋 吉孝.
  • Organizer: 第71回日本栄養・食糧学会大会
• [Presentation] 自然薯粉末の嚥下調整食への応用を目指した物性解析とその特性をいかしたレシピの検討. (2017)
  • Author(s): 津嘉山 泉、山田 万里花、田中 充樹、戸田 圭祐、木本 眞順美、中村 孝文、山本 登志子.
  • Organizer: 第71回日本栄養・食糧学会大会
• [Presentation] 嚥下音および筋電図を用いた嚥下評価系の構築とそれを用いた自然薯粉末の嚥下調整食としての評価. (2017)
  • Author(s): 山本 登志子、田中 充樹、戸田 圭祐、長崎 祐樹、田中 将夢、木本 眞順美、中村 孝文.
  • Organizer: 第71回日本栄養・食糧学会大会
• [Presentation] 赤米ポリフェノールによる乾癬症状の軽減 (2017)
  • Author(s): 戸田圭祐、津嘉山泉、北條奈々、伊東秀之、我如古菜月、川上祐生、高橋吉孝、山本登志子.
  • Organizer: 第71回日本栄養・食糧学会大会
• [Presentation] ウシ生乳中リポカリン型プロスタグランジンD合成酵素の精製と酵素学的性質ならびに乳房炎のバイオマーカーとしての検討． (2017)
  • Author(s): 山本登志子，川井恵梨佳，田中充樹，長崎祐樹，戸田圭祐，川上祐生，高橋吉孝，木本眞順美，山本圭，村上誠．
  • Organizer: 脂質生化学会
• [Presentation] ウシ生乳中リポカリン型プロスタグランジンD合成酵素の精製と酵素学的性質ならびに乳房炎のバイオマーカーとしての検討. (2017)
  • Author(s): 川井恵理佳，田中充樹，戸田圭祐，目賀拓斗，川上祐生，高橋吉孝，木本眞順美，山本登志子.
  • Organizer: 日本農芸化学会2017
• [Presentation] 乾癬モデルマウスにおける赤米ポリフェノールの抗炎症効果 (2017)
  • Author(s): 戸田圭祐、津嘉山泉、北條奈々、伊東秀之、我如古菜月、川上祐生、高橋吉孝、山本登志子.
  • Organizer: 日本農芸化学会2017
• [Presentation] Red rice polyphenol suppresses prostaglandin E2 synthesis and has preventive effects on psoriasis. (2017)
  • Author(s): Keisuke Toda, Yuki Nagasaki, Izumi Tsukayama, Mitsuki Tanaka, Erika Kawai, Natsuki Ganeko, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto.
  • Organizer: The 8th International Conference of Polyphenols and Health (ICPH2017).
  • Int'l Joint Research
• [Presentation] Catalytic activity of 12-lipoxygenase immunoprecipitated by an antibody against platelet-type 12-lipoxygenase in liver cytosol prepared from NASH model mice. (2017)
  • Author(s): Yoshiko Mori, Yuki Kawakami, Keita Kanzaki, Toshiko Suzuki-Yamamoto, Yoshitaka Takahashi.
  • Organizer: 58th International Conference on Bioscience of Lipid (ICBL)
  • Int'l Joint Research
• [Presentation] 慢性炎症を予防する食品機能性の探索． (2017)
  • Author(s): 山本登志子．
  • Organizer: 第4回日本栄養改善学会四国支部学術総会．
• [Presentation] 嚥下音及び筋電図を用いた嚥下調整食評価系の構築 (2016)
  • Author(s): 田中充樹, ，津嘉山泉，目賀拓斗，戸田圭祐，中村孝文，山本登志子.
  • Organizer: 第39回日本生体医工学会 中国四国支部大会
  • Place of Presentation: 徳島
  • Year and Date: 2016-10-15
• [Presentation] Effect of Dioscorea japonica extract and diosgenin on prostaglandin E2 synthetic pathway. (2016)
  • Author(s): Takuto Mega, Izumi Tsukayama, Keisuke Toda, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiya Arakawa, Toshiko Suzuki-Yamamoto.
  • Organizer: The 10th Joint Conference on Nutrition and Food Science
  • Place of Presentation: Daejun, Korea
  • Year and Date: 2016-10-08
  • Int'l Joint Research / Invited
• [Presentation] 自然薯抽出物と含有成分ジオスゲニンのプロスタグランジンE2合成系抑制効果. (2016)
  • Author(s): 目賀拓斗, 津嘉山泉, 戸田圭祐, 伊東秀之, 川上祐生, 高橋吉孝, 荒川俊哉, 山本(鈴木)登志子.
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台，宮城
  • Year and Date: 2016-09-25
• [Presentation] 非アルコール性脂肪性肝炎モデルマウス肝における血小板型12S-リポキシゲナーゼの発現上昇． (2016)
  • Author(s): 森香子, 大槻朱美, 川上祐生, 神崎圭太, 山本登志子, 川上貴代, 木本眞順美, 山下広美, 高橋吉孝．
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台，宮城
  • Year and Date: 2016-09-25
• [Presentation] Effect of Dioscorea japonica extract and diosgenin on prostaglandin E2 synthetic pathway. (2016)
  • Author(s): Izumi Tsukayama, Takuto Mega, Keisuke Toda, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiya Arakawa, Toshiko Suzuki-Yamamoto.
  • Organizer: 57th International Conference on the Bioscience of Lipids
  • Place of Presentation: Chamonix-Mont-Blanc, France
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] Purification and characterization of bovine lipocalin-type prostaglandin D synthase from cow’s raw milk. (2016)
  • Author(s): Toshiko Suzuki-Yamamoto, Mitsuki Tanaka, Erika Kawai, Keisuke Toda, Takuto Mega, Yuki Kawakami, Yoshitaka Takahashi, Kei Yamamoto, Makoto Murakami.
  • Organizer: 57th International Conference on the Bioscience of Lipids
  • Place of Presentation: Chamonix-Mont-Blanc, France
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] ウシ生乳由来リポカリン型プロスタグランジンD合成酵素の精製と酵素学的性質. (2016)
  • Author(s): 川井恵梨佳, 田中充樹, 瀬来由衣, 戸田圭祐, 目賀拓斗, 川上祐生, 高橋吉孝, 木本眞順美, 山本圭, 村上誠, 山本登志子.
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 神戸，兵庫
  • Year and Date: 2016-05-13
• [Presentation] 非アルコール性脂肪性肝炎進展における12-リポキシゲナーゼの役割 (2016)
  • Author(s): 森 香子、大槻 朱美、川上 祐生、神崎 圭太、山本 登志子、川上 貴代、木本 眞順美、山下 広美、辻 英明、高橋 吉孝.
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 神戸，兵庫
  • Year and Date: 2016-05-13
• [Presentation] 皮膚癌モデルマウスにおける自然薯の抗炎症・抗腫瘍効果． (2016)
  • Author(s): 津嘉山泉，武田泰典，戸田圭祐，目賀拓斗，川上祐生，高橋吉孝，木本眞順美，山本圭，村上誠，山本登志子．
  • Organizer: 日本農芸化学会2016
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-27
• [Presentation] 自然薯のプロスタグランジンE2合成系抑制と含有成分ジオスゲニンの効果． (2016)
  • Author(s): 目賀拓斗，戸田圭祐，津嘉山泉，伊東秀之，川上祐生，高橋吉孝，木本眞順美，荒川俊哉,山本登志子．
  • Organizer: 日本農芸化学会2016
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-27
• [Presentation] 嚥下調整食開発に向けた自然薯低温乾燥粉末の物性ならびに嚥下機能評価． (2016)
  • Author(s): 田中充樹，大野智子，野村奈央，津嘉山泉，戸田圭祐，目賀拓斗，川井恵梨佳，中村孝文，木本眞順美，山本登志子．
  • Organizer: 日本農芸化学会2016
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-27
• [Presentation] ヒトのタンパク質アルギニンメチル基転移酵素３（PRMT３）に対するモノクローナル抗体の作製並びに免疫学的性質． (2015)
  • Author(s): 森本亮祐，山本沙也加，津嘉山泉，山本登志子，鈴木麻季子，山下広美，高橋吉孝，木本眞須美．
  • Organizer: 第38回日本分子生物学会年会，第88回日本生化学会大会 合同大会．
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Myristica fragrans成分による5-リポキシゲナーゼ阻害効果． (2015)
  • Author(s): 川上祐生，森香子，岡本憲典，大河内脩史，金山友紀，金子由季，神崎圭太，山本登志子，木本眞順美，山下広美，伊東秀之，高橋吉孝．
  • Organizer: 第38回日本分子生物学会年会，第88回日本生化学会大会 合同大会．
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 牛乳由来リポカリン型プロスタグランジンD合成酵素の精製と酵素学的性質． (2015)
  • Author(s): 田中充樹，木本眞須美，川井恵理佳，瀬来由衣，戸田圭祐，目賀拓斗，川上祐生，高橋吉孝，山本圭，村上誠，山本登志子．
  • Organizer: 第38回日本分子生物学会年会，第88回日本生化学会大会 合同大会．
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 自然薯の新規食品機能性と含有成分ジオスゲニンの効果. (2015)
  • Author(s): 目賀拓斗，津嘉山泉，武田泰典，戸田圭祐，山本登志子.
  • Organizer: 第47回おかやまバイオアクティブ研究会シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2015-11-14
• [Presentation] 自然薯低温乾燥粉末の食品機能性の探索とそれを活かした高齢者食の開発． (2015)
  • Author(s): 山本登志子
  • Organizer: 公益財団法人 ひと・健康・未来研究財団 2015年度 助成研究発表会．
  • Place of Presentation: 京都
  • Year and Date: 2015-11-07
• [Presentation] Dioscorea japonica extract suppresses cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in lung carcinoma A549 cells. (2015)
  • Author(s): Keisuke Toda, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto.
  • Organizer: 14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases.
  • Place of Presentation: Budapest, Hungary.
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] Preventive effect of Dioscorea japonica on squamous cell carcinoma of the mouse skin involving down-regulation of prostaglandin E2 synthetic pathway. 14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases. (2015)
  • Author(s): Izumi Tsukayama, Yasunori Takeda , Takuto Mega, Keisuke Toda, Yuki Kawakami, Yoshitaka Takahashi, Masumi Kimoto, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
  • Organizer: 14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases.
  • Place of Presentation: Budapest, Hungary.
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] Purification and characterization of bovine lipocalin-type prostaglandin D synthase from cow’s milk. 14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases. (2015)
  • Author(s): Toshiko Suzuki-Yamamoto, Mitsuki Tanaka, Erika Kawai, Keisuke Toda, Yui Serai, Takuto Mega, Yuki Kawakami, Yoshitaka Takahashi, Kei Yamamoto, Makoto Murakami, Masumi Kimoto.
  • Organizer: 14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases.
  • Place of Presentation: Budapest, Hungary.
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] Inhibitory effect of nutmeg extracts on 5-lipoxygenase activity. (2015)
  • Author(s): Yuki Kawakami, Yoshiko Mori, Kensuke Okamoto, Shuji Okochi, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Hiromi Yamashita, Hideyuki Ito, Yoshitaka Takahashi.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Physiological Significance of The Metabolic Pathways for Methylated Arginines in Rat Brain. (2015)
  • Author(s): Sayaka Yamamoto, Toshiko Suzuki-Yamamoto, Arisa Ito, Suzuko Kaminoura, Yuki Kawakami, Hiromi Yamashita, Hitomi Hatakenaka, Yoshitaka Takahashi, Masumi Kimoto.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin. (2015)
  • Author(s): Yasunori Takeda, Izumi Tsukayama, Takuto Mega, Keisuke Toda, Mitsuki Tanaka, Yuki Kawakami, Yoshitaka Takahashi, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Dioscorea japonica extract suppresses cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in lung carcinoma A549 cells and macrophage-like RAW264 cells. (2015)
  • Author(s): Keisuke Toda, Izumi Tsukayama, Takuto Mega, Mitsuki Tanaka, Yasunori Takeda, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Remarks]
  • URL: http://www.fhw.oka-pu.ac.jp/eiyo/staff/index.html