Novel physiological function of vitamin E to prevent the onset of typeII diabetes
| Project/Area Number |
15K00811
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Ochanomizu University |
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Principal Investigator |
Fujiwara Yoko お茶の水女子大学, 基幹研究院, 教授 (50293105)
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| Co-Investigator(Kenkyū-buntansha) |
石川 朋子 お茶の水女子大学, ヒューマンライフイノベーション研究所, 特任准教授 (70212850)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ビタミンE / インスリン抵抗性 / β細胞 / 耐糖能 / 肥満 / インスリン / 膵β細胞 |
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| Outline of Final Research Achievements |
Type II diabetes is characterized by a progressive decline in beta-cell function and chronic insulin resistance. It is caused by the rupture of pancreatic function after long time exposure to hyperglycemia by obesity. As Japanese people genetically have low insulin secretion ability, they tend to be a type II diabetes, prevention before disease onset is important. This study aimed to show the evidence that tocotrienol (T3), a homolog of vitamin E, would be effective to prevent the onset of Type II diabetes by retention the insulin secretion ability of mice fed with a high fat diet. We clarified a part of beta cell function maintenance and its mechanism of action by vitamin E from both animal experiment and cell culture.
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Report
(4 results)
Research Products
(7 results)
