| Project/Area Number |
15K00813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
|
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| Research Institution | Kanazawa University |
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Principal Investigator |
Nagata Naoto 金沢大学, 医学系, 講師 (70456408)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Iida Noriho 金沢大学, 医学系, 助教 (40705604)
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | エネルギー代謝 / 肥満 / 機能性食品因子 / 腸内細菌叢 / 慢性炎症 / ブロッコリースプラウト / 食品機能性因子 |
|---|
| Outline of Final Research Achievements |
Glucoraphanin, a phytochemical in broccoli sprouts, attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity in high fat diet (HFD)-fed wild-type mice but not in HFD-fed Nrf2 knockout mice. Glucoraphanin increased uncoupling protein-1 (Ucp-1) protein levels in subcutaneous adipose depots, thereby increased energy expenditure. In addition, glucoraphanin suppressed Desulfovibrionaceae in gut microbiomes of HFD-fed mice, and decreased plasma lipopolysaccharide levels. By promoting fat browning, limiting metabolic
endotoxemia-related chronic inflammation, and modulating
redox stress, glucoraphanin may mitigate obesity, insulin resistance, and nonalcoholic fatty liver disease.
|
