Regulation of inflammation and energy metabolism by broccoli sprout extract
| Project/Area Number |
15K00813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kanazawa University |
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Principal Investigator |
Nagata Naoto 金沢大学, 医学系, 講師 (70456408)
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| Co-Investigator(Renkei-kenkyūsha) |
Iida Noriho 金沢大学, 医学系, 助教 (40705604)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | エネルギー代謝 / 肥満 / 機能性食品因子 / 腸内細菌叢 / 慢性炎症 / ブロッコリースプラウト / 食品機能性因子 |
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| Outline of Final Research Achievements |
Glucoraphanin, a phytochemical in broccoli sprouts, attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity in high fat diet (HFD)-fed wild-type mice but not in HFD-fed Nrf2 knockout mice. Glucoraphanin increased uncoupling protein-1 (Ucp-1) protein levels in subcutaneous adipose depots, thereby increased energy expenditure. In addition, glucoraphanin suppressed Desulfovibrionaceae in gut microbiomes of HFD-fed mice, and decreased plasma lipopolysaccharide levels. By promoting fat browning, limiting metabolic
endotoxemia-related chronic inflammation, and modulating
redox stress, glucoraphanin may mitigate obesity, insulin resistance, and nonalcoholic fatty liver disease.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017
Author(s)
Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S and Ota T.
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Journal Title
Diabetes
Volume: 印刷中
Issue: 5
Pages: 1222-1236
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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