| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Since dementia is hardly cured after onset, prevention in the daily life before onset is important. Consumption of effective molecules by diet is one of the way to the prevention. In this study, we analyzed if some dietary molecules, which showed neuroprotective activities against endoplasmic reticulum stress and oxidative stress, regulates epigenetics, especially histone deacetylase (Hdac) activities and other intracellular mechanisms for neuroprotection. I found that Hdac 1, 3 specific inhibitor MS275 protects neuronal cells and increased mitochondrial amount. ClassIII Hdac activating molecule nicotinamide mononucleotide (NMN) also increased mitochondrial amount and protected the cells from oxidative stress. Our data suggests that regulation of Hdac activity by nutritional molecules will contribute to the development of functional foods via novel mechanisms for preventing dementia.
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