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Basic analysis for developing dementia preventing foods via regulating epigenetics

Research Project

Project/Area Number 15K00814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKoshien University

Principal Investigator

Nagai Kaoru  甲子園大学, 栄養学部, 教授 (20340953)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords認知症 / ヒストン脱アセチル化酵素 / ミトコンドリア / 神経変性疾患 / 機能性食品 / 認知症予防 / Hdac
Outline of Final Research Achievements

Since dementia is hardly cured after onset, prevention in the daily life before onset is important. Consumption of effective molecules by diet is one of the way to the prevention. In this study, we analyzed if some dietary molecules, which showed neuroprotective activities against endoplasmic reticulum stress and oxidative stress, regulates epigenetics, especially histone deacetylase (Hdac) activities and other intracellular mechanisms for neuroprotection. I found that Hdac 1, 3 specific inhibitor MS275 protects neuronal cells and increased mitochondrial amount. ClassIII Hdac activating molecule nicotinamide mononucleotide (NMN) also increased mitochondrial amount and protected the cells from oxidative stress. Our data suggests that regulation of Hdac activity by nutritional molecules will contribute to the development of functional foods via novel mechanisms for preventing dementia.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A-C and their derivatives2018

    • Author(s)
      Kobayashi, S.*; Hamada, Y.; Yasumoto, T.; Hashino, Y.; Masuyama, A.; Nagai, K.*
    • Journal Title

      Tetrahedron Lett.

      Volume: 59 Issue: 18 Pages: 1733-1736

    • DOI

      10.1016/j.tetlet.2018.03.065

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions.2017

    • Author(s)
      Takakura K(1), Ito S(1), Sonoda J(1), Tabata K, Shiozaki M, Nagai K, Shibata M, Koike M, Uchiyama Y, Gotow T
    • Journal Title

      Heliyon

      Volume: 3 Issue: 11 Pages: e00462-e00462

    • DOI

      10.1016/j.heliyon.2017.e00462

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioremediation of the neonicotinoid insecticide clothianidin by the white-rot fungus Phanerochaete sordida.2016

    • Author(s)
      Mori T, Wang J, Tanaka Y, Nagai K, Kawagishi H, Hirai H.
    • Journal Title

      J. Hazard. Mater.

      Volume: 321 Pages: 586-590

    • NAID

      120006501668

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] NMN(ニコチンアミドモノヌクレオチド)のPC12細胞におけるミトコンドリア機能亢進を介した酸化ストレスからの細胞保護効果2018

    • Author(s)
      伊藤章悟、長井薫
    • Organizer
      平成30年度日本農芸化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NMNのPC12細胞におけるミトコンドリア機能亢進を介した酸化ストレスからの細胞保護効果2017

    • Author(s)
      伊藤章悟、長井薫
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Histone deacetylase inhibitor MS-275 protects Neuro2a cells from endoplasmic reticulum stress via mitochondrial enhancement.2016

    • Author(s)
      Nagai K, Shirazawa H.
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cyto-protective and toxic effects of Cordyceps militaris and cordycepin on rat CNS neurons and PC12 cells.2016

    • Author(s)
      2.Tabata K, Ito S, Sonoda J, Takakura K, Nagai K, Shiozaki M, Shibata M, Koike M, Uchiyama Y, Gotow T
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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