Inhibition of the extracellular export of mature IL-1beta by spice extracts
| Project/Area Number |
15K00815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
Ogura Yasunori 奈良女子大学, 生活環境科学系, 教授 (60304557)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKUZAKI Hiroe 奈良女子大学, 生活環境科学系, 教授 (60291598)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 炎症制御 / IL-1β / 香辛料 / ＩＬ―１β / 炎症性サイトカイン / 香辛料成分 / ポリフェノール / 細胞外輸送経路 |
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| Outline of Final Research Achievements |
We have found that extracts of 4 spices, i.e. Chinese pepper, cinnammon, Chinese star anise and clove inhibit secretion of IL-1beta from macrophages without affecting either of activation of caspase-1, cleavage of pro-IL-1beta or activation of GSDMD. This finding suggested that the extract of these spices inhibits the extracellular transport of mature IL-1beta at the downstream of GSDMD.
We then tested the activity of tanninc acid on the IL-1beta secretion because all these spices were speculated to contains gallotannin. As a result, we have confirmed that commercially available tannic acid specimens has the same activity as the extracts of the spices, but 1,2,3,4,6-pentagalloyl glucose does not. This suggested that a certain molecular species containing galloyl glucose may specifically inhibit the extracellular transport of mature IL-1beta.
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Report
(4 results)
Research Products
(1 results)
