| Project/Area Number |
15K00818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Okayama University |
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Principal Investigator |
Kobashi Motoi 岡山大学, 医歯薬学総合研究科, 准教授 (80161967)
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| Co-Investigator(Kenkyū-buntansha) |
島谷 祐一 東京都市大学, 工学部, 准教授 (20154263)
美藤 純弘 岡山大学, 医歯薬学総合研究科, 助教 (20240872)
松尾 龍二 岡山大学, 医歯薬学総合研究科, 教授 (30157268)
藤田 雅子 岡山大学, 医歯薬学総合研究科, 助手 (40156881)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | GLP-1 / 嚥下 / 延髄 / 上喉頭神経 / ラット / 最後野 / 孤束核 / インクレチン / exendin |
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| Outline of Final Research Achievements |
The effects of glucagon like peptide-1 (GLP-1), which is appetite-reducing peptide, on reflex swallowing were examined using anaesthetized rats. GLP-1 suppressed reflex swallowing via the medial part of the NTS in the dorsal medulla. Orexin-A, which is appetite enhancing peptide, also suppressed reflex swallowing. The administration of orexin-A prior to the injection of GLP-1 attenuated the degree of suppression of the swallowing response induced by GLP-1-administration. Suppression of reflex swallowing by appetite-related peptides is thought to be helpful in keeping the ability of reflex swallowing constant in cooperation with the suppression ofappetite-enhancing peptides.
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