Preventive effect of biotin in the hypothalamus and pancreatic islets on the development of type 2 diabetes
| Project/Area Number |
15K00825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Niigata Prefecture |
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Principal Investigator |
Sone Hideyuki 新潟県立大学, 人間生活学部, 教授 (90398511)
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| Research Collaborator |
KAMIYAMA Shin 新潟県立大学, 人間生活学部, 准教授 (70525401)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ビオチン / 摂食抑制 / 肥満 / 脂質代謝亢進 / 高脂肪食 / 2型糖尿病 / glucokinase / 視床下部 / 膵島細胞 / 膵β細胞 / グルコキナーゼ |
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| Outline of Final Research Achievements |
In the present study, we investigated the preventive effect of biotin on the development of type 2 diabetes. We showed that biotin suppressed food intake and body weight gain and increased pancreatic islet cell division. Additionally, biotin elevated the expression of glucokinase gene in both the hypothalamus and pancreatic islets. Glucokinase leads to excitation of the glucose-responsible neuron in hypothalamus which resulted in satiety, and to activation of the IRS-2 pathway which further resulted in the promotion of pancreatic islet cell division to preserve normal function. Moreover, biotin strongly suppressed body weight gain in high-fat diet induced obesity mice via the acceleration of fat catabolism. These findings suggest that biotin prevents obesity and hyperglycemia via the suppression of food intake by inducing satiety, elevation of fat metabolism, and the maintenance of normal pancreatic islet function, leading to the prevention of the development of type 2 diabetes.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、ビオチンが高血糖に応答する共通分子としてグルコキナーゼを介し膵島細胞と視床下部を調節することにより、日本人２型糖尿病（非肥満型）を予防するといった新たな発想に基づいている。ビオチンは過剰症の心配のない水溶性のビタミンであり、生体にとってより安全な使用が可能である。また、過食と膵β細胞の量的不足は多くの２型糖尿病に共通する発症要因であり、疾病予防・改善の両面で応用範囲が広く有効性も高いと考えられる。本研究の中核的な課題の１つであるビオチンによるエピゲノム制御は、栄養素による２型糖尿病の新たな予防・治療法の先行研究として多くの注目を集め、今後の研究・教育面において幅広く活用できる。
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Report
(5 results)
Research Products
(3 results)
