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Regulation of sugar and lipid metabolism after the intake of high-sugar diet

Research Project

Project/Area Number 15K00827
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

Morita Akihito  静岡県立大学, 食品栄養科学部, 助教 (40239653)

Co-Investigator(Kenkyū-buntansha) 三浦 進司  静岡県立大学, 食品栄養科学部, 教授 (10342932)
Research Collaborator SATO TOMOKI  静岡県立大学, 大学院・薬食生命科学総合学府
SENO NANAMI  静岡県立大学, 大学院・薬食生命科学総合学府
INOUE MIZUKI  静岡県立大学, 大学院・薬食生命科学総合学府
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脂質代謝 / 糖質代謝 / 糖質過剰摂取 / phosphatidylcholine / バイオマーカー / GPD1 / 絶食 / 再摂食 / SREBP-1c / 高糖質食 / 高脂質食 / ホスファチジルコリン / 脂質合成 / ホスファチジルコリン分子種 / フラクトース 6-ホスフェート / UDP-GlcNAc / LXR / 脂肪酸分子種
Outline of Final Research Achievements

We analyze the regulation of sugar and lipid metabolism after intake of high sugar diet. We did not prove the hypothesis that the increased hepatic store of glycogen initiated the biosynthesis of fatty acid after fasting and refeeding. Glycerol 3-phosphate dehydrogenase 1 (GPD1) catalyzes the conversion process between sugar and lipid metabolism. In GPD1 null mouse, contribution of lipid oxidation as a fuel source for exercise is increased, and gluconeogenesis from glycogenic amino acids is also increased after fasting. Finally, we demonstrated that the blood level of any phosphatidylcholine (PC), such as PC(16:0/16:1) and PC(16:0/18:1), was increased after intake of high sugar diet, suggesting that these two PCs would be good biomarkers for intake of high sugar diet.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (56 results)

All 2017 2016 2015 Other

All Journal Article (8 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (47 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Effects of the dietary carbohydrate?fat ratio on plasma phosphatidylcholine profiles in human and mouse2017

    • Author(s)
      Inoue Mizuki、Senoo Nanami、Sato Tomoki、Nishimura Yuri、Nakagawa Takumi、Miyoshi Noriyuki、Goda Toshinao、Morita Akihito、Miura Shinji
    • Journal Title

      The Journal of Nutritional Biochemistry

      Volume: 50 Pages: 83-94

    • DOI

      10.1016/j.jnutbio.2017.08.018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PGC-1αによる筋機能調節 : 運動を分子レベルから考える2017

    • Author(s)
      三浦進司、只石幹、妹尾奈波、畑澤幸乃、三好規之、守田昭仁、亀井康富、江崎治
    • Journal Title

      日本未病システム学会雑誌

      Volume: 23 Pages: 67-71

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 炭水化物、脂質の摂取比率に応答する血中phosphatidylcholine分子の発見2017

    • Author(s)
      1.井上瑞樹、妹尾奈波、佐藤友紀、西村友里、中川匠、三好規之、合田敏尚、守田昭仁、三浦進司
    • Journal Title

      脂質生化学研究

      Volume: 59 Pages: 51-53

    • Related Report
      2017 Annual Research Report
  • [Journal Article] PGC-1αによる骨格筋Cardiolipin脂肪酸組成の制御2017

    • Author(s)
      妹尾奈波、三好規之、守田昭仁、三浦進司
    • Journal Title

      脂質生化学研究

      Volume: 59 Pages: 87-88

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 骨格筋中のリン脂質に結合する脂肪酸種は筋線維タイプによって異なる2017

    • Author(s)
      梅林脩平、妹尾奈波、佐藤友紀、三好規之、守田昭仁、三浦進司
    • Journal Title

      脂質生化学研究

      Volume: 59 Pages: 266-269

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Glycerol-3-phosphate dehydrogenase 1 deficiency induces compensatory amino acid metabolism during fasting in mice.2016

    • Author(s)
      Sato, T., Yoshida, Y., Morita, A., Mori, N., and Miura, S.
    • Journal Title

      Metabolism

      Volume: 65 Pages: 1646-1656

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 「非アルコール性脂肪肝の食事要因を診断する新規マーカーの探索」2016

    • Author(s)
      井上瑞樹、佐藤友紀、妹尾奈波、西村友里、三好規之、守田昭仁、三浦進司
    • Journal Title

      脂質生化学研究

      Volume: 58 Pages: 51-52

    • Related Report
      2016 Research-status Report
  • [Journal Article] Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise.2015

    • Author(s)
      Sato, T., Morita, A., Mori, N., and Miura, S.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 457 Pages: 653-658

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 転写共役因子PGC-1αによって制御される骨格筋リポクオリティー2017

    • Author(s)
      三浦進司、妹尾奈波、梅林脩平、守田昭仁、三好規之、亀井康富
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会、第90回日本生化学会大会)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] トマト未利用資源由来トマチジンの筋萎縮予防作用および体内動態2017

    • Author(s)
      佐山音緒、吉田悠馬、糠谷東雄、鈴木貴則、塩谷茂信、守田昭仁、若林敬二、三浦進司
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線維タイプによる骨格筋リン脂質に結合する脂肪酸種の相違2017

    • Author(s)
      梅林脩平、妹尾奈波、佐藤友紀、三好規之、守田昭仁、三浦進司
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PGC-1αによる18:2含有Cardiolipin合成の促進2017

    • Author(s)
      妹尾奈波、三好規之、守田昭仁、三浦進司
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 持久運動トレーニングによる動脈硬化抑制機序の解明2017

    • Author(s)
      榛葉有希、十河華子、妹尾奈波、池田雅彦、守田昭仁、三浦進司
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 災害時における健康維持に関する研究~非定常作業量のモデル化および備蓄食糧の評価~2017

    • Author(s)
      石田愛弓、佐野文美、守田昭仁、三浦進司、市川陽子
    • Organizer
      第5回日本災害食学会発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炭水化物、脂質の摂取比率に応答する血中phosphatidylcholine分子の発見2017

    • Author(s)
      井上瑞樹、妹尾奈波、佐藤友紀、西村友里、中川匠、三好規之、合田敏尚、守田昭仁、三浦進司
    • Organizer
      第59回日本脂質生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PGC-1αによる骨格筋Cardiolipin脂肪酸組成の制御2017

    • Author(s)
      妹尾奈波、三好規之、守田昭仁、三浦進司
    • Organizer
      第59回日本脂質生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格筋中のリン脂質に結合する脂肪酸種は筋線維タイプによって異なる2017

    • Author(s)
      梅林脩平、妹尾奈波、佐藤友紀、三好規之、守田昭仁、三浦進司
    • Organizer
      第59回日本脂質生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PGC-1αやFOXO1を用いた骨格筋機能評価系の構築2017

    • Author(s)
      守田昭仁、長池祐太、竹内彩夏、中川匠、望月裕介、亀井康富、三浦進司
    • Organizer
      日本農芸化学会2017年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Protein kinase inihibitorによる筋萎縮抑制作用2017

    • Author(s)
      中川匠、守田昭仁、竹内彩夏、長池祐太、佐山音緒、渡辺優衣、小郷尚久、浅井章良、亀井康富、三浦進司
    • Organizer
      日本農芸化学会2017年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] keletal muscle specific PGC-1α overexpression prevents atherosclerosis in apolipoprotein E knockout mice.2017

    • Author(s)
      Shimba, Y., Togawa, H., Senoo, N., Ikeda, M., Morita, A., and Miura, S.
    • Organizer
      The 22nd Shizuoka Forum on Health and Longevity
    • Related Report
      2017 Annual Research Report
  • [Presentation] Muscle fiber type-dependent differences in phospholipid fatty acid composition (involvement of PGC-1α).2017

    • Author(s)
      Umebayashi, S., Senoo, N., Sato, T., Miyoshi, N., Morita, A., and Miura, S.
    • Organizer
      The 22nd Shizuoka Forum on Health and Longevity
    • Related Report
      2017 Annual Research Report
  • [Presentation] KIS-154, a FOXO1 inhibitor, is one of the candidate compounds to prevent skeletal muscle atrophy.2017

    • Author(s)
      Watanabe, Y., Nakagawa, T., Morita, A., Ogo, N., Asai, A., Kamei, Y., and Miura, S.
    • Organizer
      The 22nd Shizuoka Forum on Health and Longevity
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of the dietary carbohydrate-fat ratio on plasma phosphatidylcholine profiles in human and mouse.2017

    • Author(s)
      Miura, S., Inoue, M., Senoo, N., Sato, T., Nishimura, Y., Nakagawa, T., Miyoshi, N., Goda, T., and Morita, A.
    • Organizer
      Gordon Research Conference, “Lipids, Molecular & Cellular Biology of,
    • Related Report
      2017 Annual Research Report
  • [Presentation] Changes in phospholipid acyl-chain compositions of skeletal muscle in response to nutritional starvation.2017

    • Author(s)
      Senoo, N., Miyoshi, N., Kobayashi, E., Morita, A., and Miura, S.
    • Organizer
      Gordon Research Conference, “Lipids, Molecular & Cellular Biology of,
    • Related Report
      2017 Annual Research Report
  • [Presentation] Muscle fiber type-dependent differences in phospholipid fatty acid composition.2017

    • Author(s)
      Umebayashi, S., Senoo, N., Sato, T., Miyoshi, N., Morita, A., Kamei, Y., and Miura, S.
    • Organizer
      Gordon Research Conference, “Lipids, Molecular & Cellular Biology of,
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glycerol-3-phosphate dehydrogenase 1 deficiency induces compensatory amino acid metabolism during fasting in mice2017

    • Author(s)
      Sato, T., Yoshida, Y., Morita, A., Mori, N., and Miura, S.
    • Organizer
      12th China-Japan Symposium on Health Sciences
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格筋における18:2含有Cardiolipin合成へのPGC-1αの関与2017

    • Author(s)
      妹尾奈波、三好規之、守田昭仁、三浦進司
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会、第90回日本生化学会大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Kinase阻害剤がPGC-1α活性に及ぼす影響2017

    • Author(s)
      望月裕介、守田昭仁、澁谷風佳、安島晴香、渡辺優衣、小郷尚久、浅井章良、亀井康富、三浦進司
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格筋の機能低下がキヌレニン代謝および「うつ」症状に与える影響2017

    • Author(s)
      石野真悠、守田昭仁、三浦進司
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 長期的な脂質、炭水化物の摂取比率に応答する血中リン脂質分子種2017

    • Author(s)
      井上瑞樹、佐藤友紀、妹尾奈波、西村友里、三好規之、合田敏尚、守田昭仁、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格筋中のリン脂質に結合する脂肪酸は筋線維タイプによって異なる2017

    • Author(s)
      梅林脩平、妹尾奈波、佐藤友紀、三好規之、守田昭仁、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 絶食後の骨格筋におけるリン脂質組成変化とFOXO1の関与2017

    • Author(s)
      妹尾奈波、三好規之、守田昭仁、亀井康富、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glycerol-3-phosphate dehydrogenase 1欠損による絶食時の代償的アミノ酸代謝亢進2017

    • Author(s)
      佐藤友紀、吉田悠馬、守田昭仁、森展子、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Foxo1を標的とした筋萎縮抑制化合物の探索2017

    • Author(s)
      渡辺優衣、中川匠、守田昭仁、小郷尚久、浅井章良、亀井康富、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] トマト未利用資源からの筋萎縮予防食材の創製2017

    • Author(s)
      佐山音緒、吉田悠馬、糠谷東雄、鈴木貴則、塩谷茂信、守田昭仁、若林敬二、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.2017

    • Author(s)
      Miura, S., Senoo, N., Miyoshi, N., Goto-Inoue, N., Minami, K., Yoshimura, R., Morita, A., Sawada, N., Matsuda, J., Ogawa, Y., Setou, M., and Kamei, Y.
    • Organizer
      12th China-Japan Symposium on Health Sciences
    • Related Report
      2017 Annual Research Report
  • [Presentation] Long-term effects of carbohydrate/fat ratio in the diet on plasma phospholipid composition in mice and human.2017

    • Author(s)
      Inoue, M., Sato, T., Senoo, N., Miyoshi, N., Goda, T., Morita, A., and Miura, S.
    • Organizer
      12th China-Japan Symposium on Health Sciences
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glycerol-3-phosphate dehydrogenase 1 deficiency induces compensatory amino acid metabolism during fasting in mice2016

    • Author(s)
      Sato, T., Yoshida, Y., Morita, A., Mori, N., and Miura, S.
    • Organizer
      The 21st Shizuoka Forum on Health and Longevity
    • Place of Presentation
      Shizuoka
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Long-term effects of carbohydrate/fat ratio in the diet on plasma phospholipid composition in mice and human.2016

    • Author(s)
      Inoue, M., Sato, T., Senoo, N., Nishimura, Y., Miyoshi, N., Goda, T., Morita, A., and Miura, S.
    • Organizer
      The 21st Shizuoka Forum on Health and Longevity
    • Place of Presentation
      Shizuoka
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 「Glycerol-3-phosphate dehydrogenase 1欠損による絶食時の代償的アミノ酸代謝亢進」2016

    • Author(s)
      佐藤友紀、吉田悠馬、守田昭仁、森展子、三浦進司:
    • Organizer
      第71回日本栄養・食糧学会中部支部大会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 「長期的な脂質、炭水化物の摂取比率に応答する血中リン脂質」2016

    • Author(s)
      井上瑞樹、佐藤友紀、妹尾奈波、西村友里、三好規之、合田敏尚、守田昭仁、三浦進司
    • Organizer
      第71回日本栄養・食糧学会中部支部大会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 「非アルコール性脂肪肝の食事要因を診断する新規マーカーの探索」2016

    • Author(s)
      井上瑞樹、佐藤友紀、妹尾奈波、西村友里、三好規之、守田昭仁、三浦進司:
    • Organizer
      第58回日本脂質生化学会大会
    • Place of Presentation
      秋田
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 「肝臓におけるインスリン非依存的な脂肪酸生合成促進機序の解明」2016

    • Author(s)
      佐藤友紀、西村友里、井上瑞樹、守田昭仁、三浦進司:
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      西宮
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 「非アルコール性脂肪肝の食事要因を診断する新規マーカーの探索」2016

    • Author(s)
      井上瑞樹、佐藤友紀、妹尾奈波、西村友里、守田昭仁、三浦進司:
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      西宮
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 非アルコール性脂肪肝の食事要因を診断する新規マーカーの探索2016

    • Author(s)
      井上瑞樹、佐藤友紀、妹尾奈波、西村友里、守田昭仁、三浦進司
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-13
    • Related Report
      2015 Research-status Report
  • [Presentation] The roles of GPD1 in maintaining blood glucose levels under fasting conditions2016

    • Author(s)
      Sato, T., Morita, A., Mori, N., and Miura, S
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-04-02
    • Related Report
      2016 Research-status Report
  • [Presentation] he roles of GPD1 in maintaining blood glucose levels under fasting conditions.2016

    • Author(s)
      Sato, T., Morita, A., Mori, N., and Miura, S.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-04-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Glycerol-3-phosphate dehydrogenase 1の血糖値維持における役割2015

    • Author(s)
      佐藤友紀、守田昭仁、森展子、三浦進司
    • Organizer
      第69回日本栄養・食糧学会中部支部大会
    • Place of Presentation
      静岡
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] The roles of GPD1 in maintaining blood glucose levels under fasting conditions2015

    • Author(s)
      Sato, T., Morita, A., Mori, N., and Miura, S.
    • Organizer
      The 20th Shizuoka Forum on Health and Longevity
    • Place of Presentation
      Shizuoka
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アルコール性脂肪肝における糖質代謝とGPD1の役割2015

    • Author(s)
      三浦進司、佐藤友紀、守田昭仁、森展子
    • Organizer
      平成27年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Glycerol-3-phosphate dehydrogenase 1欠損は運動中の脂肪酸酸化量を増加させることにより運動持久力を向上させる2015

    • Author(s)
      三浦進司、佐藤友紀、守田昭仁、森展子
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise2015

    • Author(s)
      Sato, T., Morita, A., Mori, N., and Miura, S.
    • Organizer
      Cell Symposia: Exercise Metabolism
    • Place of Presentation
      Amsterdam
    • Year and Date
      2015-07-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of lipogenic gene expression in postprandial liver2015

    • Author(s)
      Nishimura, Y., Sato, T., Inoue, M., Miura, S., and Morita, A.
    • Organizer
      The 12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The roles of GPD1 in exercise capacity2015

    • Author(s)
      Sato, T., Morita, A., Mori, N., and Miura, S.
    • Organizer
      The 12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肝臓におけるインスリン非依存的な脂肪酸生合成促進機序の解明2015

    • Author(s)
      佐藤友紀、西村友里、井上瑞樹、守田昭仁、三浦進司
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-13
    • Related Report
      2015 Research-status Report
  • [Remarks] 静岡県立大学・食品栄養科学部・栄養化学研究室

    • URL

      http://dfns.u-shizuoka-ken.ac.jp/labs/nutrbioc/index3.html/Home.html

    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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