Regulation of sugar and lipid metabolism after the intake of high-sugar diet
| Project/Area Number |
15K00827
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Morita Akihito 静岡県立大学, 食品栄養科学部, 助教 (40239653)
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| Co-Investigator(Kenkyū-buntansha) |
三浦 進司 静岡県立大学, 食品栄養科学部, 教授 (10342932)
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| Research Collaborator |
SATO TOMOKI 静岡県立大学, 大学院・薬食生命科学総合学府
SENO NANAMI 静岡県立大学, 大学院・薬食生命科学総合学府
INOUE MIZUKI 静岡県立大学, 大学院・薬食生命科学総合学府
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脂質代謝 / 糖質代謝 / 糖質過剰摂取 / phosphatidylcholine / バイオマーカー / GPD1 / 絶食 / 再摂食 / SREBP-1c / 高糖質食 / 高脂質食 / ホスファチジルコリン / 脂質合成 / ホスファチジルコリン分子種 / フラクトース 6-ホスフェート / UDP-GlcNAc / LXR / 脂肪酸分子種 |
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| Outline of Final Research Achievements |
We analyze the regulation of sugar and lipid metabolism after intake of high sugar diet. We did not prove the hypothesis that the increased hepatic store of glycogen initiated the biosynthesis of fatty acid after fasting and refeeding. Glycerol 3-phosphate dehydrogenase 1 (GPD1) catalyzes the conversion process between sugar and lipid metabolism. In GPD1 null mouse, contribution of lipid oxidation as a fuel source for exercise is increased, and gluconeogenesis from glycogenic amino acids is also increased after fasting. Finally, we demonstrated that the blood level of any phosphatidylcholine (PC), such as PC(16:0/16:1) and PC(16:0/18:1), was increased after intake of high sugar diet, suggesting that these two PCs would be good biomarkers for intake of high sugar diet.
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Report
(4 results)
Research Products
(56 results)
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[Presentation] keletal muscle specific PGC-1α overexpression prevents atherosclerosis in apolipoprotein E knockout mice.2017
Author(s)
Shimba, Y., Togawa, H., Senoo, N., Ikeda, M., Morita, A., and Miura, S.
Organizer
The 22nd Shizuoka Forum on Health and Longevity
Related Report
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[Presentation] Muscle fiber type-dependent differences in phospholipid fatty acid composition (involvement of PGC-1α).2017
Author(s)
Umebayashi, S., Senoo, N., Sato, T., Miyoshi, N., Morita, A., and Miura, S.
Organizer
The 22nd Shizuoka Forum on Health and Longevity
Related Report
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[Presentation] KIS-154, a FOXO1 inhibitor, is one of the candidate compounds to prevent skeletal muscle atrophy.2017
Author(s)
Watanabe, Y., Nakagawa, T., Morita, A., Ogo, N., Asai, A., Kamei, Y., and Miura, S.
Organizer
The 22nd Shizuoka Forum on Health and Longevity
Related Report
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[Presentation] Effects of the dietary carbohydrate-fat ratio on plasma phosphatidylcholine profiles in human and mouse.2017
Author(s)
Miura, S., Inoue, M., Senoo, N., Sato, T., Nishimura, Y., Nakagawa, T., Miyoshi, N., Goda, T., and Morita, A.
Organizer
Gordon Research Conference, “Lipids, Molecular & Cellular Biology of,
Related Report
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[Presentation] Changes in phospholipid acyl-chain compositions of skeletal muscle in response to nutritional starvation.2017
Author(s)
Senoo, N., Miyoshi, N., Kobayashi, E., Morita, A., and Miura, S.
Organizer
Gordon Research Conference, “Lipids, Molecular & Cellular Biology of,
Related Report
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[Presentation] Muscle fiber type-dependent differences in phospholipid fatty acid composition.2017
Author(s)
Umebayashi, S., Senoo, N., Sato, T., Miyoshi, N., Morita, A., Kamei, Y., and Miura, S.
Organizer
Gordon Research Conference, “Lipids, Molecular & Cellular Biology of,
Related Report
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[Presentation] PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.2017
Author(s)
Miura, S., Senoo, N., Miyoshi, N., Goto-Inoue, N., Minami, K., Yoshimura, R., Morita, A., Sawada, N., Matsuda, J., Ogawa, Y., Setou, M., and Kamei, Y.
Organizer
12th China-Japan Symposium on Health Sciences
Related Report
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[Presentation] Long-term effects of carbohydrate/fat ratio in the diet on plasma phospholipid composition in mice and human.2017
Author(s)
Inoue, M., Sato, T., Senoo, N., Miyoshi, N., Goda, T., Morita, A., and Miura, S.
Organizer
12th China-Japan Symposium on Health Sciences
Related Report
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[Presentation] Long-term effects of carbohydrate/fat ratio in the diet on plasma phospholipid composition in mice and human.2016
Author(s)
Inoue, M., Sato, T., Senoo, N., Nishimura, Y., Miyoshi, N., Goda, T., Morita, A., and Miura, S.
Organizer
The 21st Shizuoka Forum on Health and Longevity
Place of Presentation
Shizuoka
Year and Date
2016-11-25
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