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Mechanism of brain aging promotion by stress and diabetes mellitus and its prevention by food components

Research Project

Project/Area Number 15K00828
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

Keiko Unno  静岡県立大学, 薬学部, 准教授 (10106437)

Co-Investigator(Kenkyū-buntansha) 木村 洋子  静岡大学, 農学部, 教授 (80291152)
住吉 晃  東北大学, 加齢医学研究所, 助教 (80612530)
Research Collaborator ISHII Sanae  
PERVIN Monira  
NAKAMURA Yoriyuki  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsストレス / 脳老化 / テアニン / カテキン / 認知症予防 / 認知症 / 糖尿病
Outline of Final Research Achievements

(1) Stress-reducing effect was demonstrated in mice and humans that ingested green tea with reduced caffeine, because the stress-reducing effect of theanine was enhanced by the suppression of antagonistic effect of caffeine.
(2) EGCG and its metabolites were investigated for blood-brain barrier permeability and neurite outgrowth action on cultured neurons (SH-SY5Y). We found that both EGCG and its metabolites enhanced the differentiation of nerve cells.
(3) In the senescence-accelerate model mouse (SAMP8), the ratio of Aβ42 to Aβ40 was significantly increased by stress load, suggesting the involvement of stress on the progression of Alzheimer's disease.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (57 results)

All 2018 2017 2016 2015

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 16 results,  Acknowledgement Compliant: 3 results) Presentation (37 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Green tea extracts ameliorate high-fat diet-induced muscle atrophy in senescence-accelerated mouse prone-8 mice.2018

    • Author(s)
      Onishi S, Ishino M, Kitazawa H, Yoto A, Shimba Y, Mochizuki Y, Unno K, Meguro S, Tokimitsu I, Miura S.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 4 Pages: e0195753-e0195753

    • DOI

      10.1371/journal.pone.0195753

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood-Brain Barrier Permeability of Green Tea Catechin Metabolites and their Neuritogenic Activity in Human Neuroblastoma SH-SY5Y Cells2017

    • Author(s)
      Unno Keiko、Pervin Monira、Nakagawa Aimi、Iguchi Kazuaki、Hara Aya、Takagaki Akiko、Nanjo Fumio、Minami Akira、Nakamura Yoriyuki
    • Journal Title

      Molecular Nutrition & Food Research

      Volume: 61 Issue: 12 Pages: 1700294-1700294

    • DOI

      10.1002/mnfr.201700294

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ingestion of green tea with lowered caffeine improves sleep quality of the elderly via suppression of stress2017

    • Author(s)
      Unno K, Noda S, Kawasaki Y, Yamada H, Morita A, Iguchi K, Nakamura Y
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 61 Issue: 3 Pages: 210-216

    • DOI

      10.3164/jcbn.17-6

    • NAID

      130006191920

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood brain barrier permeability of (-)-epigallocatechin gallate, its proliferation-enhancing activity of human neuroblastoma SH-SY5Y cells, and its preventive effect on age-related cognitive dysfunction in mice.2017

    • Author(s)
      Monira Pervin, Keiko Unno, Aimi Nakagawa, Yuu Takahashi, Kazuaki Iguchi, Hiroyuki Yamamoto, Minoru Hoshino, Aya Hara, Akiko Takagaki, Fumio Nanjo, Akira Minami, Shinjiro Imai, Yuriyuki Nakamura
    • Journal Title

      Biochem. Biophys. Rep.

      Volume: 9 Pages: 180-186

    • DOI

      10.1016/j.bbrep.2016.12.012

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study2017

    • Author(s)
      Unno K, Yamada H, Iguchi K, Ishida H, Iwao Y, Morita A, Nakamura Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 6 Pages: 902-909

    • DOI

      10.1248/bpb.b17-00141

    • NAID

      130005688068

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced Stress and Improved Sleep Quality Caused by Green Tea Are Associated with a Reduced Caffeine Content2017

    • Author(s)
      Unno K, Noda S, Kawasaki Y, Yamada H, Morita A, Iguchi K, Nakamura Y.
    • Journal Title

      Nutrients

      Volume: 9 Issue: 7 Pages: 777-777

    • DOI

      10.3390/nu9070777

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement in Cognitive Function with Green Soybean Extract May Be Caused by Increased Neuritogenesis and BDNF Expression2017

    • Author(s)
      Pervin M, Unno K, Nakayama Y, Ikemoto H, Imai S, Iguchi K, Minami A, Nakamura Y
    • Journal Title

      J Food Process Technol

      Volume: 8 Issue: 10 Pages: 695-695

    • DOI

      10.4172/2157-7110.1000695

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-stress effect of green tea with lowered caffeine on humans: A pilot study2017

    • Author(s)
      Keiko Unno, Hiroshi Yamada, Kazuaki lguchi, Hitoshi lshida, Yasunori Iwao, Akio Morita, Yoriyuki Nakamura.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 印刷中

    • NAID

      130005688068

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ingestion of green tea with lowered caffeine improves sleep quality of the elderly via suppression of stress2017

    • Author(s)
      Keiko Unno, Shigenori Noda, Yohei Kawasaki, Hiroshi Yamada, Akio Morita, Kazuaki Iguchi, Yoriyuki Nakamura
    • Journal Title

      J Clin Biochem Nutr

      Volume: 印刷中

    • NAID

      130006191920

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible Gender Difference in Anti-stress Effect of β-Cryptoxanthin2016

    • Author(s)
      Keiko Unno, Shigenori Noda, Yohei Kawasaki, Kazuaki Iguchi, Hiroshi Yamada:
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 136 Issue: 9 Pages: 1255-1262

    • DOI

      10.1248/yakushi.16-00017

    • NAID

      130005261346

    • ISSN
      0031-6903, 1347-5231
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anti-stress effects of drinking green tea with lowered caffeine and enriched theanine, epigallocatechin and arginine on psychosocial stress induced adrenal hypertrophy in mice.2016

    • Author(s)
      Keiko Unno, Ayane Hara, Aimi Nakagawa, Kazuaki Iguchi, Megumi Ohshio, Akio Morita, Yoriyuki Nakamura
    • Journal Title

      Phytomedicine

      Volume: 23 Issue: 12 Pages: 1365-1375

    • DOI

      10.1016/j.phymed.2016.07.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prevention of brain aging by green tea components: Role of catechins and theanine2016

    • Author(s)
      Keiko Unno
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 5 Issue: 2 Pages: 117-122

    • DOI

      10.7600/jpfsm.5.117

    • NAID

      130005151605

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stable isotope dilution HILIC-MS/MS method for accurate quantification of glutamic acid, glutamine, pyroglutamic acid, GABA and theanine in mouse brain tissues.2016

    • Author(s)
      Inoue K, Miyazaki Y, Unno K, Min JZ, Todoroki K, Toyo'oka T.
    • Journal Title

      Biomed Chromatogr.

      Volume: 30(1) Issue: 1 Pages: 55-61

    • DOI

      10.1002/bmc.3502

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 食品成分による老化およびストレスの予防2015

    • Author(s)
      海野けい子
    • Journal Title

      薬学雑誌

      Volume: 135(1) Pages: 41-46

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 食品の機能性研究最前線:老化とストレス2015

    • Author(s)
      高橋良哉、海野けい子
    • Journal Title

      薬学雑誌

      Volume: 135(1) Pages: 31-32

    • NAID

      130004756456

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 緑茶成分による脳の老化予防2015

    • Author(s)
      海野けい子
    • Journal Title

      Food Style 21

      Volume: 19(10) Pages: 39-42

    • Related Report
      2015 Research-status Report
    • Open Access
  • [Presentation] 抹茶の飲用がストレス軽減に与える影響:ランダム化比較試験による検討2018

    • Author(s)
      浜本伸吾、大島大資、仁井寛彦、井口和明、中村順行、海野けい子、山田 浩
    • Organizer
      第33回茶学術研究会講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 緑茶カテキンによる脳の老化抑制の機構解明2018

    • Author(s)
      パービン・モニラ、海野けい子、井口和明、寺脇 彩、高垣晶子、南条文雄、中村順行
    • Organizer
      第33回茶学術研究会講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抹茶のストレス軽減作用:成分組成の違いの影響2018

    • Author(s)
      海野けい子、浜本伸吾、大島大資、井口和明、山田 浩、森田明雄、堀江秀樹、中村順行
    • Organizer
      第33回茶学術研究会講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Green soybean extracts increases neuritogenesis in SH-SY5Y cells and BDNF expression in mouse brain2018

    • Author(s)
      Monira Pervin, Keiko Unno, Yuya Nakayama, Hiroyuki Ikemoto, Shinjiro Imai, Kazuaki Iguchi, Akira Minami, Yoko Kimura, Yoriyuki Nakamura
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 緑茶カテキンによる認知機能低下予防のメカニズム2018

    • Author(s)
      海野けい子、Monira Pervin、井口和明、南 彰、原 彩、高垣晶子、南条文雄、中村順行
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Green tea extracts ameliorate high-fat diet induced muscle atrophy in SAMP8 mice2017

    • Author(s)
      Shintaro Onishi, Mayu Ishino, Hidefumi Kitazawa, Yuki Shimba, Yusuke Mochizuki, Shinji Miura, Keiko Unno, Shinichi Meguro, Ichiro Tokimitsu
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology: Aging and Mechanisms of Aging-Related Disease (Yokohama)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improved Sleep Quality of the Elderly via Suppression of Stress: Effects of Green Tea Components2017

    • Author(s)
      Keiko Unno, Shigenori Noda, Yohei Kawasaki, Hiroshi Yamada, Akio Morita, Kazuaki Iguchi, Yuriyuki Nakamura
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology: Aging and Mechanisms of Aging-Related Disease (Yokohama)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevention of age-related cognitive dysfunction: Mechanism of action of green tea catechins on mouse brain2017

    • Author(s)
      Monira Pervin, Keiko Unno, Aimi Nakagawa, Kazuaki Iguchi, Aya hara, Akiko Takagaki, Fumio Nanjo, Akira Minami, Yoriyuki Nakamura
    • Organizer
      10th World Congress on Nutrition & Food Sciences (Osaka)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 緑茶カテキンによる脳の老化抑制機構の解明2017

    • Author(s)
      海野けい子、Monira Pervin、中川愛美、井口和明、原 彩、高垣晶子、南条文雄、中村順行
    • Organizer
      第17回日本抗加齢医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Suppression of Decline in Cognitive Function by Green Tea Catechin2017

    • Author(s)
      Keiko Unno, Monira Pervine, Akira Minami, Kazuaki Iguchi, Aya Hara, Akiko Takagaki, Fumio Nanjo, Yoriyuki Nakamura
    • Organizer
      日本基礎老化学会第40回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 緑茶カテキンによるSAMP10の寿命延長ならびに脳機能低下抑制2017

    • Author(s)
      海野けい子、Monira Pervin、井口和明、中村順行
    • Organizer
      第32回老化促進モデルマウス (SAM) 学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 社会心理的ストレスによる脳の萎縮とその後の回復2017

    • Author(s)
      海野けい子、小西智一、住吉 晃、野中博意、井口和明、井之上浩一、豊岡利正、川島隆太、林美智子、パービン・モニラ、中村順行
    • Organizer
      第12回臨床ストレス応答学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 緑茶カテキンの脳機能低下抑制作用における機構解明2017

    • Author(s)
      海野けい子
    • Organizer
      第14回日本カテキン学会年次学術大会2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Role of Green Tea Catechin Metabolites: A Study of the Blood-Brain Barrier Permeability and the Neuritogenic Activity2017

    • Author(s)
      Monira Pervin、Keiko Unno、Aya Hara, Akiko Takagaki,Fumio Nanjo, Kazuaki Iguchi、Akira Minami、Yoriyuki Nakamura
    • Organizer
      第14回日本カテキン学会年次学術大会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mechanism of action of green tea catechins on the brain: Blood brain barrier permeability, cognitive function and nerve cell differentiation2017

    • Author(s)
      Keiko Unno, Monira Pervin, Aimi Nakagawa, Kazuaki Iguchi, Aya Hara, Akiko Takagaki, Fumio Nanjo, Akira Minami, Yuriyuki Nakamura
    • Organizer
      BIT’s 5th Annual World Conference of Geriatrics and Gerontology-2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of green tea with lowered caffeine on stress and sleep quality of the elderly.2016

    • Author(s)
      Shigenori Noda, Keiko Unno, Yohei Kawasaki, Megumi Ohshio, Akio Morita, Kazuaki Iguchi, Yuriyuki Nakamura, Hiroshi Yamada
    • Organizer
      The 3rd International Conference on Farm and Nutrition
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] The effect of tea catechins on age-related muscle atrophy.2016

    • Author(s)
      Mayu Ishino, Hidefumi Kitazawa, Shintaro Ohnishi, Keiko Unno, Shinichi Meguro, Ichiro Tokimitsu, Akihiko Morita, Shinji Miura
    • Organizer
      The 3rd International Conference on Farm and Nutrition
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Effect of green tea catechins on cognitive function in mice and neuronal cell growth and differentiation.2016

    • Author(s)
      Monira Pervin, Aimi Nakagawa, Akira Minami, Shinjiro Imai, Yuriyuki Nakamura, Keiko Unno
    • Organizer
      The 3rd International Conference on Farm and Nutrition
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 脂質の過剰摂取による脳老化の促進ならびに茶カテキンによるその予防2016

    • Author(s)
      大西慎太郎、海野けい子、Monira Pervin、石野真悠、榛葉有希、望月裕介、三浦進司、北澤秀文、目黒真一、時光一郎
    • Organizer
      第32回茶学術研究会講演会・第13回日本カテキン学会年次学術大会・合同大会2016
    • Place of Presentation
      静岡
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 茶カテキンによる脳の老化抑制およびそのメカニズムの解明2016

    • Author(s)
      海野けい子、Monira Pervin、井口和明、原 彩、高垣晶子、南条文雄、中村順行
    • Organizer
      第32回茶学術研究会講演会・第13回日本カテキン学会年次学術大会・合同大会2016
    • Place of Presentation
      静岡
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 老化に伴う筋萎縮への茶カテキンの効果~SAMP8マウスでの検討~2016

    • Author(s)
      石野真悠、北澤秀文、陽東 藍、海野けい子、目黒真一、時光一郎、三浦進司
    • Organizer
      第31回老化促進モデルマウス (SAM) 研究協議会
    • Place of Presentation
      京都
    • Year and Date
      2016-07-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 緑茶カテキンによる脳の加齢変化抑制の機構解明2016

    • Author(s)
      海野けい子、Monira Pervin、中川愛美、井口和明、原 彩、高垣晶子、南条文雄、中村順行
    • Organizer
      第31回老化促進モデルマウス (SAM) 研究協議会
    • Place of Presentation
      京都
    • Year and Date
      2016-07-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 緑茶の抗ストレス作用における成分間の相互作用2016

    • Author(s)
      海野けい子、原文音、中川愛美、井口和明、大塩 恵、森田明雄、中村順行
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Preventive effect of green tea catechins on cognitive dysfunction2016

    • Author(s)
      パービン・モニラ、中川愛美、原 彩、高垣晶子、南条文雄、今井伸二郎、中村順行、海野けい子
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 高齢者の睡眠に対する緑茶成分の作用2016

    • Author(s)
      海野けい子、野田誠紀、川崎洋平、山田 浩、大塩 恵、森田明雄、井口和明、中村順行
    • Organizer
      日本基礎老化学会第39回大会
    • Place of Presentation
      神奈川県伊勢原市
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 緑茶の抗ストレス作用に関する検討:テアニン、カテキン、カフェインの相互作用2016

    • Author(s)
      海野けい子、原 文音、井口和明、林美智子、中村順行
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 緑茶カテキンの血液脳関門透過性と培養神経細胞に対する作用2016

    • Author(s)
      Monira Pervin, Aimi Nakagawa, Aya Hara, Akiko Takagaki, Fumio Nanjo, Shinjiro Imai, Yoriyuki Nakamura, Keiko Unno
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 低カフェイン緑茶による高齢者の睡眠ならびにストレスへの影響に関する検討2016

    • Author(s)
      野田誠紀、海野けい子、川崎洋平、井口 和明、中村 順行、山田 浩
    • Organizer
      茶学術研究会30周年記念大会講演会
    • Place of Presentation
      静岡
    • Year and Date
      2016-03-14
    • Related Report
      2015 Research-status Report
  • [Presentation] EGCGとその代謝物の血液脳関門透過性ならびに培養神経細胞に対する作用2016

    • Author(s)
      パービン・モニラ、中川愛美、原 彩、高垣晶子、南条文雄、今井伸二郎、中村順行、海野けい子
    • Organizer
      茶学術研究会30周年記念大会講演会
    • Place of Presentation
      静岡
    • Year and Date
      2016-03-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 緑茶の抗ストレス作用に関する検討2016

    • Author(s)
      海野けい子、原 文音、中川愛美、井口和明、大塩 恵、森田明雄、中村順行
    • Organizer
      茶学術研究会30周年記念大会講演会
    • Place of Presentation
      静岡
    • Year and Date
      2016-03-14
    • Related Report
      2015 Research-status Report
  • [Presentation] Anti-stress effect of low-caffeine green tea2015

    • Author(s)
      Keiko Unno, Hiroshi Yamada, Ayane Hara, Kazuaki Iguchi, Yoriyuki Nakamura
    • Organizer
      19th International Conference of Functional Food Center
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-11-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Suppression of cognitive dysfunctionby green tea catechin2015

    • Author(s)
      Monira Pervin, Aimi Nakagawa, Aya Hara, Fumio Nanjo, Shinjiro Imai, Yoko Kimura, Yuriyuki Nakamura, Keiko Unno
    • Organizer
      19th International Conference of Functional Food Center
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-11-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] のばそう健康寿命:脳の健康と維持2015

    • Author(s)
      海野けい子
    • Organizer
      第2回女性未来農業創造シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 緑茶カテキンの血液脳関門透過に関する検討2015

    • Author(s)
      海野けい子、中村順行、井口和明、林美智子、モニラ・パービン
    • Organizer
      USフォーラム2015(静岡県立大学学術フォーラム)
    • Place of Presentation
      静岡
    • Year and Date
      2015-09-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 緑茶によるストレス軽減2015

    • Author(s)
      海野けい子
    • Organizer
      シーズ&ニーズビジネスマッチング研究発表会
    • Place of Presentation
      静岡
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 社会心理的ストレスによる脳の萎縮ならびにその予防2015

    • Author(s)
      海野けい子、住吉 晃、野中博意、川島隆太、井之上浩一、宮崎康人、豊岡利正、井口和明、林美智子、中村順行
    • Organizer
      第30回老化促進モデルマウス (SAM) 研究協議会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳の老化促進における社会心理的ストレスの関与ならびにその予防2015

    • Author(s)
      海野けい子、住吉 晃、野中博意、小西智一、原 文音、井口和明、井之上浩一、宮崎康人、豊岡利正、川島隆太、林美智子、中村順行
    • Organizer
      日本基礎老化学会第38回大会
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
  • [Book] Health Benefits of Green Tea, An Evidence-based Approach2017

    • Author(s)
      Keiko Unno
    • Publisher
      CABI
    • ISBN
      9781786392398
    • Related Report
      2017 Annual Research Report
  • [Book] 茶の事典2017

    • Author(s)
      海野けい子
    • Publisher
      朝倉書店
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳神経細胞増殖促進剤2017

    • Inventor(s)
      海野けい子、原 彩、高垣晶子、
    • Industrial Property Rights Holder
      海野けい子、原 彩、高垣晶子、
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2017-061438
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳神経細胞増殖促進剤2015

    • Inventor(s)
      海野けい子、原 彩、高垣晶子
    • Industrial Property Rights Holder
      海野けい子、原 彩、高垣晶子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-07-24
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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