Mechanism of brain aging promotion by stress and diabetes mellitus and its prevention by food components
| Project/Area Number |
15K00828
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Keiko Unno 静岡県立大学, 薬学部, 准教授 (10106437)
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| Co-Investigator(Kenkyū-buntansha) |
木村 洋子 静岡大学, 農学部, 教授 (80291152)
住吉 晃 東北大学, 加齢医学研究所, 助教 (80612530)
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| Research Collaborator |
ISHII Sanae
PERVIN Monira
NAKAMURA Yoriyuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ストレス / 脳老化 / テアニン / カテキン / 認知症予防 / 認知症 / 糖尿病 |
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| Outline of Final Research Achievements |
(1) Stress-reducing effect was demonstrated in mice and humans that ingested green tea with reduced caffeine, because the stress-reducing effect of theanine was enhanced by the suppression of antagonistic effect of caffeine.
(2) EGCG and its metabolites were investigated for blood-brain barrier permeability and neurite outgrowth action on cultured neurons (SH-SY5Y). We found that both EGCG and its metabolites enhanced the differentiation of nerve cells.
(3) In the senescence-accelerate model mouse (SAMP8), the ratio of Aβ42 to Aβ40 was significantly increased by stress load, suggesting the involvement of stress on the progression of Alzheimer's disease.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Blood brain barrier permeability of (－)-epigallocatechin gallate, its proliferation-enhancing activity of human neuroblastoma SH-SY5Y cells, and its preventive effect on age-related cognitive dysfunction in mice.2017
Author(s)
Monira Pervin, Keiko Unno, Aimi Nakagawa, Yuu Takahashi, Kazuaki Iguchi, Hiroyuki Yamamoto, Minoru Hoshino, Aya Hara, Akiko Takagaki, Fumio Nanjo, Akira Minami, Shinjiro Imai, Yuriyuki Nakamura
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Journal Title
Biochem. Biophys. Rep.
Volume: 9
Pages: 180-186
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 緑茶カテキンの血液脳関門透過性と培養神経細胞に対する作用2016
Author(s)
Monira Pervin, Aimi Nakagawa, Aya Hara, Akiko Takagaki, Fumio Nanjo, Shinjiro Imai, Yoriyuki Nakamura, Keiko Unno
Organizer
日本薬学会第136年会
Place of Presentation
横浜
Year and Date
2016-03-27
Related Report
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