| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study is to regulate the higher brain function via tryptophan metabolite kynurenic acid by control of amino acids metabolism. We showed that inhibition of large neutral amino acid transporter (LAT) suppressed brain kynurenic acid production, and intake of LAT substrate amino acids also suppressed the high tryptophan diet-induced kynurenic acid production in rat brain. We investigated the tryptophan metabolism in animal model, and acute liver failure model rat showed enhancement of brain kynurenic acid production. Although mild non-alcoholic steatohepatitis affected peripheral tryptophan metabolism, these change failed to affect brain kynurenic acid. These results showed that influence on tryptophan metabolism in the brain and peripheral depend on respective liver failure.
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