| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In this study, we studied about preventive effect of food components on neurotoxicity, cognitive impairment and motor function.
1’-Acetoxychavicol acetate (ACA) naturally obtained from the rhizomes and seeds of Alpinia galangal suppressed amyloid beta-induced neurotoxicity by enhancing the proteasome activity which is degrading unnecessary proteins. Furthermore, ACA improved the cognitive function in senescence-accelerated mice prone 8 (SAMP8) as same level as senescence-accelerated resistant/1 (SAMR1) mice, a homologous control. We found that ACA repaired the cerebral hippocampal tissue responsible for memory to suppresses neuronal damage by increasing serum ketone body concentration as an alternative energy source for glucose. We also found that extract of mate tea had a protective effect against oxidative stress-induced neurotoxicity in vitro Parkinson’s disease.
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