A comprehensive study of food components having preventive effect on dementia

• Project/Area Number: 15K00832
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Osaka City University
• Principal Investigator: Kojima-Yuasa Akiko 大阪市立大学, 大学院生活科学研究科, 准教授 (90295709)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 機能性食品成分 / 認知症 / アルツハイマー病 / パーキンソン病 / ナンキョウ / ACA / ケトン体 / マテ茶 / 6-OHDA / Nrf2-ARE経路 / ロータロッド / ロテノン / 老化促進モデルマウス（SAMP8） / Y字迷路試験 / モーリス水迷路試験 / 神経変性疾患

Outline of Final Research Achievements

In this study, we studied about preventive effect of food components on neurotoxicity, cognitive impairment and motor function.
1’-Acetoxychavicol acetate (ACA) naturally obtained from the rhizomes and seeds of Alpinia galangal suppressed amyloid beta-induced neurotoxicity by enhancing the proteasome activity which is degrading unnecessary proteins. Furthermore, ACA improved the cognitive function in senescence-accelerated mice prone 8 (SAMP8) as same level as senescence-accelerated resistant/1 (SAMR1) mice, a homologous control. We found that ACA repaired the cerebral hippocampal tissue responsible for memory to suppresses neuronal damage by increasing serum ketone body concentration as an alternative energy source for glucose. We also found that extract of mate tea had a protective effect against oxidative stress-induced neurotoxicity in vitro Parkinson’s disease.

Research Products

• [Journal Article] 1’-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells (2017)
  • Author(s): Kojima-Yuasa, A., Yamamoto, T., Yaku, K., Hirota, S., Matsui-Yuasa, I.
  • Journal Title: Annals of Nutrition and Metabolism Volume: 71 Pages: 379-380
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protective effects of hydrolyzed nucleoproteins from salmon milt against ethanol-induced liver injury in rats (2017)
  • Author(s): Matsui-Yuasa, I., Goto, M., Yoshikawa, E., Morita, Y., Sekiguchi, H., Sutoh, K., Usumi, K., Kojima-Yuasa, A.
  • Journal Title: Annals of Nutrition and Metabolism Volume: 71 Pages: 1197-1198
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Extract of traditional picking melon prevents ethanol-induced liver injury in rats (2017)
  • Author(s): Kojima-Yuasa, A., Hirauchi, E., Sawada, T., Kasahara, A., Yoshikawa, E., Tamura, A. and Matsui-Yuasa, I.
  • Journal Title: International Journal of Food and Nutritional Science Volume: 6 Pages: 56-66
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 認知症の予防効果を有する食品成分とその作用メカニズム (2017)
  • Author(s): 湯浅（小島）明子
  • Journal Title: アグリバイオ Volume: 1 Pages: 103-106
• [Journal Article] 1’-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells (2016)
  • Author(s): Kojima-Yuasa, A., Yamamoto, T., Yaku, K., Hirota, S., Takenaka, S., Kawabe, K. and Matsui-Yuasa, I
  • Journal Title: Chemico-Biological Interactions Volume: 257 Pages: 101-109
  • DOI: 10.1016/j.cbi.2016.07.031
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Protective effects of hydrolyzed nucleoproteins from salmon milt against ethanol-induced liver injury in rats (2016)
  • Author(s): Kojima-Yuasa, A., Goto, M., Yoshikawa, E., Morita, Y., Sekiguchi, H., Sutohe, K., Usumi, K. and Matsui-Yuasa, I.
  • Journal Title: Marin Drugs Volume: 14 Issue: 12 Pages: 232-244
  • DOI: 10.3390/md14120232
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synergistic anticancer activities of natural substances in human hepatocellular carcinoma (2015)
  • Author(s): Kojima-Yuasa, A., Haung, X. and Matsui-Yuasa, I.
  • Journal Title: Disease Volume: 3 Issue: 4 Pages: 260-281
  • DOI: 10.3390/diseases3040260
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ecklonia cava polyphenol has a protective effect against ethanol-induced liver injury in a cyclic AMP-dependent manner (2015)
  • Author(s): Yamashita, H., Goto, M., Matsui-Yuasa, I. and Kojima-Yuasa, A.
  • Journal Title: Marin Drugs Volume: 13 Issue: 6 Pages: 3877-3891
  • DOI: 10.3390/md13063877
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 1'-Acetoxychavicol acetateの認知機能改善効果にはプロテアソーム活性の亢進と血清ケトン体濃度の増加が関与する (2017)
  • Author(s): 湯浅（小島）明子、夜久圭介、山本富矢、広田栞、川辺光一、竹中重雄、湯浅勲
  • Organizer: 第90回日本生化学会大会
• [Presentation] 1’-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells (2017)
  • Author(s): Kojima-Yuasa, A., Yamamoto, T., Yaku, K., Hirota, S., Matsui-Yuasa, I.
  • Organizer: International Congress of Nutrition
  • Int'l Joint Research
• [Presentation] Protective effects of hydrolyzed nucleoproteins from salmon milt against ethanol-induced liver injury in rats (2017)
  • Author(s): Matsui-Yuasa, I., Goto, M., Yoshikawa, E., Morita, Y., Sekiguchi, H., Sutoh, K., Usumi, K., Kojima-Yuasa, A.
  • Organizer: International Congress of Nutrition
  • Int'l Joint Research
• [Presentation] The synergistic effect of 1’-acetoxychavicol acetate and sodium butyrate on the death of human hepatocellular carcinoma cells (2016)
  • Author(s): Matsui-Yuasa, I., Kato R. and Kojima-Yuasa, A.
  • Organizer: 5th Annual World Congress of Food and Nutrition 2016
  • Place of Presentation: Kaohsing, Taiwan
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] Yerba-Mate (Ilex paraguariensis) extract prevents ethanol-induced liver injury in rats (2016)
  • Author(s): Kojima-Yuasa, A., Tamura, A., Sasaki, M., Yamashita, H., Saku, T., Hikima, T. and Matsui-Yuasa, I.
  • Organizer: 5th Annual World Congress of Food and Nutrition 2016
  • Place of Presentation: Kaohsing, Taiwan
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] 1’-Acetoxychavicol acetateは血清ケトン体濃度を亢進させることによって認知機能を改善させる (2016)
  • Author(s): 広田 栞，山本富矢，夜久圭介，竹中繁雄，川辺光一，湯浅 勲，湯浅（小島）明子
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 武庫川女子大学（兵庫県西宮市）
  • Year and Date: 2016-05-13
• [Presentation] The synergistic anticancer activity of 1’-acetoxychavicol acetate and sodium butyrate in human hepatocellular carcinoma cells (2016)
  • Author(s): Matsui-Yuasa, I. and Kojima-Yuasa, A.
  • Organizer: American Association for Cancer Research Annual Meeting 2016
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] マテ茶抽出物による神経傷害に対する保護効果 (2016)
  • Author(s): 広田 栞，湯浅 勲，湯浅（小島）明子
  • Organizer: 第55回日本栄養・食糧学会近畿支部大会
  • Place of Presentation: 帝塚山学院大学（大阪府堺市）
• [Presentation] Ecklonia cavaポリフェノールはcAMP依存性にアルコール性肝疾患を予防する。 (2015)
  • Author(s): 湯浅（小島）明子，山下治香、高橋麻衣、後藤真由、湯浅 勲
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2015-10-11
• [Presentation] 1’-Acetoxychavicol acetateによる皮膚の創傷治癒効果 (2015)
  • Author(s): 森 厚樹，湯浅 勲，菅原弘二，鶴田大輔，湯浅（小島）明子
  • Organizer: 日本栄養・食糧学会第54回近畿支部大会
  • Place of Presentation: 神戸大学（兵庫県・神戸市）
  • Year and Date: 2015-10-10
• [Presentation] 老化促進モデルマウスにおける1’-acetoxychavicol acetateの認知機能障害予防効果 (2015)
  • Author(s): 広田 栞，山本富矢，湯浅 勲，湯浅（小島）明子
  • Organizer: 日本栄養・食糧学会第54回近畿支部大会
  • Place of Presentation: 神戸大学（兵庫県・神戸市）
  • Year and Date: 2015-10-10
• [Presentation] 金芽米抽出物による抗ガン効果とその作用メカニズム (2015)
  • Author(s): 大重善裕，関口博太，須藤慶太，宇住晃治，湯浅 勲，湯浅（小島）明子
  • Organizer: 日本栄養・食糧学会第54回近畿支部大会
  • Place of Presentation: 神戸大学（兵庫県・神戸市）
  • Year and Date: 2015-10-10
• [Presentation] 甘苦茶 (Mallotus furetianus) 抽出物による抗ガン作用メカニズム (2015)
  • Author(s): 清水悠介，黄 雪丹，白畑辰弥，小林義典，湯浅 勲，湯浅（小島）明子
  • Organizer: 日本栄養・食糧学会第54回近畿支部大会
  • Place of Presentation: 神戸大学（兵庫県・神戸市）
  • Year and Date: 2015-10-10
• [Presentation] Ecklonia cava polyphenolによるアルコール性肝細胞傷害の予防効果とその作用メカニズム (2015)
  • Author(s): 後藤麻由，山下治香，湯浅 勲，湯浅（小島）明子
  • Organizer: 日本栄養・食糧学会第54回近畿支部大会
  • Place of Presentation: 神戸大学（兵庫県・神戸市）
  • Year and Date: 2015-10-10
• [Presentation] 1’-acetoxychavicol acetateと酪酸はヒト肝ガン細胞のアポトーシス細胞死を相乗的に誘導する。 (2015)
  • Author(s): 湯浅（小島）明子
  • Organizer: 第37回日本臨床栄養学会総会・第36回日本臨床栄養協会総会 第13回大連合大会
  • Place of Presentation: 都市センターホテル（東京都・千代田区）
  • Year and Date: 2015-10-02
• [Presentation] The effect of 1’-acetoxychavicol acetate on human skin wound healing (2015)
  • Author(s): Mori, A., Sugawara, K., Tsuruta, D., Matsui-Yuasa, I. and Kojima-Yuasa, A.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: パシフィコ横浜 （神奈川県・横浜市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] The construction of insulin resistance model of 3T3-L1 (2015)
  • Author(s): Kase, T., Matsui-Yuasa, I. and Kojima-Yuasa, A.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: パシフィコ横浜 （神奈川県・横浜市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Anti-cancer effect and the mechanism of extract of Mallotus furetianus (2015)
  • Author(s): Shimizu, Y., Huang, X., Shirahata, T. Kobayashi, Y., Matsui-Yuasa, I. and Kojima-Yuasa, A.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: パシフィコ横浜 （神奈川県・横浜市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] The extract of the outer layer of rice inhibits tumor cell growth (2015)
  • Author(s): Oshige, Y., Sekiguchi, H., Sutoh, K., Usumi, K., Matsui-Yuasa, I. and Kojima-Yuasa, A.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: パシフィコ横浜 （神奈川県・横浜市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Book] カレント臨床栄養学 (2015)
  • Author(s): 湯浅（小島）明子
  • Total Pages: 346
  • Publisher: 建帛社
• [Patent(Industrial Property Rights)] ケトン体産生促進剤 (2016)
  • Inventor(s): 湯浅明子、湯浅勲
  • Industrial Property Rights Holder: 公立大学法人大阪市立大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-035897
  • Filing Date: 2016-02-26