Ameliorative effects of dietary beta-conglycinin in metabolic syndrome
Project/Area Number |
15K00834
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
|
Research Institution | University of Nagasaki |
Principal Investigator |
Koba Kazunori 長崎県立大学, 看護栄養学部, 教授 (30290638)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | β-コングリシニン / 脂肪組織重量 / 肝臓トリグリセリド濃度 / 血圧 / 血糖値 / ラット / マウス / メタボリックシンドローム / 血圧上昇抑制 / アディポネクチン / 抗肥満 / インスリン耐性試験 / 脂質代謝 / インスリン感受性 |
Outline of Final Research Achievements |
We examined how dietary β-conglycinin, one of the major components of soy protein affected metabolic syndrome factors in disease animal models. As a result, dietary β-conglycinin lowered visceral adipose tissue weights and liver triglyceride concentration in Otsuka Long Evans Tokushima Fatty (OLETF) rats (an animal model of obesity). Dietary β-conglycinin suppressed both systolic and diastolic blood pressures in spontaneously hypertensive rats (SHR/Izm). Also, Dietary β-conglycinin ameliorated insulin sensitivity in KK-Ay mice (a mouse model of type II diabetes mellitus). These effects were also observed in SHR/NDmcr-cp, which was a metabolic syndrome rat model. The results suggested that β-conglycinin could modulate not only lipid metabolism, but also glucose metabolism and blood pressure in rodents, and then β-conglycinin has potential to prevent metabolic syndrome.
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Report
(4 results)
Research Products
(4 results)