| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We examined how dietary β-conglycinin, one of the major components of soy protein affected metabolic syndrome factors in disease animal models. As a result, dietary β-conglycinin lowered visceral adipose tissue weights and liver triglyceride concentration in Otsuka Long Evans Tokushima Fatty (OLETF) rats (an animal model of obesity). Dietary β-conglycinin suppressed both systolic and diastolic blood pressures in spontaneously hypertensive rats (SHR/Izm). Also, Dietary β-conglycinin ameliorated insulin sensitivity in KK-Ay mice (a mouse model of type II diabetes mellitus). These effects were also observed in SHR/NDmcr-cp, which was a metabolic syndrome rat model. The results suggested that β-conglycinin could modulate not only lipid metabolism, but also glucose metabolism and blood pressure in rodents, and then β-conglycinin has potential to prevent metabolic syndrome.
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