| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
This study demonstrated that consumption of fermentable non-digestible carbohydrates, including soluble dietary fiber and oligosaccharides, commonly elevated colonic ALP activity by up-regulation of the expression of IAP-I in rats fed a high-fat diet. On the other hand, β-glucosidase activity was not affected by the present dietary manipulation. Colon ALP correlated with colonic luminal variables such as mucins, cecal n-butyrate and fecal ratio of Bifidobacterium spp. that are associated with improvement of colonic environment. These results suggest that the elevating effects of fermentable non-digestible carbohydrates on colonic ALP might be important for protection of gut epithelial homeostasis.
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