| Project/Area Number |
15K00837
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
Saito Maki 岩手医科大学, 薬学部, 助教 (40365185)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
田辺 由幸 横浜薬科大学, 薬学部, 教授 (10275109)
鎌滝 章央 弘前大学, 医学研究科, 助教 (60360004)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 肺高血圧症 / 魚油 / コーン油 / アスピリン / モノクロタリン / 多価不飽和脂肪酸 / 肺高血圧 |
|---|
| Outline of Final Research Achievements |
It has been reported that n-3 polyunsaturated fatty acids, such as EPA and DHA, which are contained richly in fish oil, are converted into inflammation resolving molecules called “resolvins” by aspirin-acetylated cyclooxygenase-2. The aim of the present study is to clarify whether co-administration of fish oil and aspirin improves symptoms of pulmonary hypertension (PH) and inflammation in monocrotaline-induced pulmonary hypertensive rat model.
Contrary to expectations, co-administration of fish oil and aspirin led to exacerbation of right ventricular hypertrophy in the monocrotaline-treated rats. Moreover, expression of inflammatory cytokines including IL-1 was augmented in the right ventricles. These results suggest that excessive intake of health food including EPA and DHA, may adversely affect proper pharmaceutical therapy.
|
