| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we investigated the effect of vitamin C on the response of endoplasmic reticulum stress by inducing an abnormal state (ER stress) in the protein quality control system of cultured cells. As a result, intracellular vitamin C suppressed the induction of some endoplasmic reticulum stress response factors, as well as the expression of factors involved in proteolysis that transport only misfolded proteins to the degradation system. This suggests that vitamin C may be deeply involved in the intracellular protein quality control system.
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