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Effect of vitamin C in protein quality control

Research Project

Project/Area Number 15K00838
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionTakasaki University of Health and Welfare

Principal Investigator

SONE Yasuko  高崎健康福祉大学, 健康福祉学部, 准教授 (80452027)

Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsビタミンC / タンパク質 / 小胞体 / レドックス / 細胞小器官
Outline of Final Research Achievements

In this study, we investigated the effect of vitamin C on the response of endoplasmic reticulum stress by inducing an abnormal state (ER stress) in the protein quality control system of cultured cells. As a result, intracellular vitamin C suppressed the induction of some endoplasmic reticulum stress response factors, as well as the expression of factors involved in proteolysis that transport only misfolded proteins to the degradation system. This suggests that vitamin C may be deeply involved in the intracellular protein quality control system.

Academic Significance and Societal Importance of the Research Achievements

本研究は、タンパク質品質管理システムおいて、小胞体ストレスを引き起こした際、ビタミンCが小胞体ストレス応答因子やタンパク質分解に関わる因子の発現を抑制したことなどを明らかとしており、ビタミンCがタンパク質品質管理システムに関与する可能性を示唆するものである。この分野についての研究はこれまでに少なく、十分に明らかとされていない。したがって、本研究で得られた知見は新規性の点から学術的意義が認められる。さらに、今後、タンパク質品質管理システムにおけるレドックス環境とビタミンCの関係、及びビタミンC摂取量とその反応性についての詳細を明らかにできれば、健康維持・増進の観点からさらに社会的意義が高まる。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2020 2017 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4.2017

    • Author(s)
      Yoko Fujiwara, Chisato Tsukahara, Naoe Ikeda, Yasuko Sone,Yasuko Sone, Tomoko Ishikawa, Ikuyo Ichi1, Taisuke Koike, and Yoshinori Aoki.
    • Journal Title

      J Clin Biochem Nutr.

      Volume: 61 Pages: 196-202

    • NAID

      130006191915

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT42017

    • Author(s)
      Yoko Fujiwara, Chisato Tsukahara, Naoe Ikeda, Yasuko Sone,Yasuko Sone, Tomoko Ishikawa, Ikuyo Ichi1, Taisuke Koike, and Yoshinori Aoki.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 印刷中

    • NAID

      130006191915

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 小胞体ストレス応答に対するビタミンCの影響2020

    • Author(s)
      曽根 保子、山本 彩矢、小林 詩歩、中川 理紗
    • Organizer
      日本家政学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 小胞体ストレス応答遺伝子に対するビタミンCの影響.2017

    • Author(s)
      曽根保子、花岡美憂、村山加奈、井野大輝.
    • Organizer
      日本ビタミン学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Efficacy of Habitual Exercise for Improving Lipid Profiles Depends on the PPAR-gamma Genotype in Japanese Males.2015

    • Author(s)
      Sone Y, Morito K, Narita T, Egawa S, Kawahara K, Otsuka Y, Fujiwara Y.
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama (Minato Mirai, Nishi-ku, Yokohama 220-0012, Japan)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tocotorienol improves the glucose tolerance in obese mice induced by high fat feeding.2015

    • Author(s)
      Sato H, Kawamura Y, Tomino S, Sonoda M, Ichi I, Sone Y, Ishikawa T, Fujiwara Y.
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama (Minato Mirai, Nishi-ku, Yokohama 220-0012, Japan)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 応用栄養学2020

    • Author(s)
      小切間美保、桒原晶子、津田謹輔、伏木亨、本田佳子
    • Total Pages
      200
    • Publisher
      中山書店
    • ISBN
      9784521742915
    • Related Report
      2019 Annual Research Report
  • [Remarks] 研究内容

    • URL

      http://www.takasaki-u.ac.jp/p_eiyo_labo/7995/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2021-02-19  

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