| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Transient forebrain ischemia causes brain inflammation such as edema and neuronal death. We found that decrease in food intake and body weight were induced by transient forebrain ischemia in mice. We also demonstrated that dietary supplementation with α-linolenic acid attenuated the anorexic responses following transient forebrain ischemia in mice but did not reduce arachidonic acid, precursor of eicosanoids content in brain phospholipids. Peripheral administration of lipopolysaccharide induces behavioral depression including feeding disorder, in which the central and peripheral inductions of proinflammatory cytokines are proposed to play an important role. We demonstrated that dietary supplementation with α-linolenic acid suppressed the gene expression of proinflammtory cytokines in the hypothalamus. These results suggest that dietaryα-linolenic acid attenuates feeding disorders by the suppression of cytokines generation rather than eicosanoids generation in hypothalamus.
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