| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
It is recognized that short-chain fatty acids (SCFA) produced by gut bacteria play important roles in energy homeostasis for the host. This study aimed to investigate the effects of hesperidin and its aglycone hesperetin on cecal SCFA in rats. Results demonstrated that hesperetin, but not hesperidin, significantly increased the SCFA pool of cecal digesta. Hesperetin limited starch digestion, suggesting that parts of undigested starch were utilized to produce SCFA by microbial fermentation in the large intestine. Treatment of diet with hesperetin significantly decreased the relative abundance of Clostridium subcluster XIVa in feces.
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