A study on the role of polyunsaturated fatty acids in the emotion formation of mouse neonates

• Project/Area Number: 15K00851
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Azabu University
• Principal Investigator: Moriguchi Toru 麻布大学, 生命・環境科学部, 教授 (10512006)
• Research Collaborator: HARAUMA Akiko 麻布大学, 生命・環境科学部, 特任准教授 (80727917)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: マウス / 多価不飽和脂肪酸 / 人工飼育 / 情動行動 / n-3系脂肪酸 / モノアミン / 食生活学 / 機能性食品

Outline of Final Research Achievements

To clear the importance of polyunsaturated fatty acids, especially n-3 fatty acids during the brain development and formation period, we investigated the importance of artificial milk containing n-3 fatty acids and measured emotional behavior and changes in monoamine content in the brain.
Artificial breeding by artificial milk is known to raise the level of anxiety rather than breeding of mothers. In addition, we detected the possibility that n-3 fatty acids in artificial milk stabilize monoamines production in the brain and its turnover rate.