Studies on dietary and exercise therapies against metabolic and locomotive disorders

• Project/Area Number: 15K00852
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanto Gakuin University
• Principal Investigator: Yamada Tetsuo 関東学院大学, 栄養学部, 教授 (90200724)
• Co-Investigator(Kenkyū-buntansha): 田中 明 女子栄養大学, 栄養学部, 教授 (70171733)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: メタボリックシンドローム / ロコモティブシンドローム / 食事療法 / 運動療法

Outline of Final Research Achievements

Protein intake, particularly branched chain amino acids (BCAAs), and exercise have opposing actions on insulin secretion, but the same action on protein anabolism. We examined the effects of BCAA-rich fat-free milk intake and/or exercise on levels of insulin secretion and indices related to muscle protein metabolism in order to assess the potency of dietary and exercise therapies against metabolic and locomotive disorders.
Adult male or female volunteers participated in the metabolic studies. Urinary C-peptide immunoreactivity excretion and serum insulin levels were significantly higher, but urinary 3-methyl-histidine excretion levels were significantly lower with low urinary catecholamine excretion in the fat-free milk-containing diet than in the control diet. These findings were reduced by exercise with high urinary catecholamine excretion. Fat-free milk intake enhanced insulin secretion and suppressed muscle protein degradation, but these effects are attenuated by exercise.

Research Products

• [Presentation] Decrease in serum insulin and IGF-1 levels after exercise under the dietary condition of increased skimmed milk Intakes (2017)
  • Author(s): Tetsuo Yamada, Masaki Okada, Masami Matsuzaki and Akira Tanaka
  • Organizer: International Conference on Frailty and Sarcopenia Research 2017
  • Place of Presentation: Barcelona, Espana
  • Year and Date: 2017-04-27
  • Int'l Joint Research
• [Presentation] Increase in Serum Insulin, Urinary C-peptide Immunoreactivity (CPR) Excretion Levels by Skimmed Milk Intakes Is Attenuated by Endurance Physical Exercise (2017)
  • Author(s): Tetsuo Yamada, Masaki Okada, Masami Matsuzaki and Akira Tanaka
  • Organizer: Experimental Biology 2017
  • Place of Presentation: Chicago, USA
  • Year and Date: 2017-04-22
  • Int'l Joint Research
• [Presentation] Increase in serum insulin, urinary C-Peptide immunoreactivity (CPR) excretion levels by skimmed milk intakes is attenuated by endurance physical exercise (2017)
  • Author(s): Tetsuo Yamada, Masaki Okada, Masami Matsuzaki, Akira Tanaka
  • Organizer: Experimental Biology 2017
  • Int'l Joint Research
• [Presentation] Decrease in serum insulin and IGF-1 levels after exercise under the dietary condition of increased skimmed milk intakes (2017)
  • Author(s): Tetsuo Yamada, Masaki Okada, Masami Matsuzaki, Akira Tanaka
  • Organizer: International Conference on Frailty and Sarcopenia Research 2017
  • Int'l Joint Research