| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In order to elucidate the cause of impaired glucose tolerance frequently occurred in young women, we examined whether insulin secretion ability is decreased by carbohydrate restriction.
Twenty-six healthy young women participated as subjects in a three-month open intervention trial taking 30% low-carbohydrate diet. We compared the results of 75 g OGTT before and after the intervention.
The insulin 30 minute value and the insulin inogenic index at 75 g OGTT decreased significantly. However, insulin sensitivity index was significantly increased and there was no significant difference in plasma glucose. As a result of examination using a generalized linear model, the factor affecting insulin secretion was only a decrease in carbohydrate intake. It was suggested that the low carbohydrate diet for 3 months reduced insulin secretion ability.
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