Research of dietary marine xanthophylls with anti-mammary carcinogenic effects
| Project/Area Number |
15K00859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Koshien University (2017-2018)
Kansai Medical University (2015-2016) |
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Principal Investigator |
Yuri Takashi 甲子園大学, 栄養学部, 教授 (50330212)
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| Co-Investigator(Kenkyū-buntansha) |
義澤 克彦 武庫川女子大学, 生活環境学部, 教授 (70548396)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | アスタキサンチン / カンタキサンチン / 乳癌 / アディポネクチン / アディポサイトカイン / N-methyl-N-nitrosourea / 試験摂取 / ヒト乳癌細胞株 |
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| Outline of Final Research Achievements |
We investigated whether short-term dietary xanthophyll administration (canthaxanthin and astaxanthin) inhibits N-methyl-N-nitrosourea (MNU)-induced rat mammary carcinogenesis during initiation until early promotional stages of cancer development. Dietary administration of astaxanthin during the initiation and early promotion stages significantly suppressed MNU-induced rat mammary carcinogenesis. In contrast, inhibitory effects of dietary canthaxanthin were not observed. The immunoblotting and immunohistochemical results indicated that a possible mechanism explaining the effects of astaxanthin might be related to the secretion of adiponectin from mammary adipocytes.
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| Academic Significance and Societal Importance of the Research Achievements |
海藻やサーモンや甲殻類に含まれるアスタキサンチンは、本邦では美白効果など美容に効果のある天然食材として知られているが、乳がんの抑制にも効果があることを病理組織学的に証明した。アスタキサンチンなどの海洋性キサントフィルは、古来から日常的に摂取されてきた食品成分であるが、本邦で増加している乳がんの抑制効果も有していることを証明したことは、国民の健康増進に寄与しうる成果と考える。
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Report
(5 results)
Research Products
(2 results)
