| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Dietary fat affect the gene expression related to lipid metabolism both in liver and intestine. Maternal high-fat diet (HFD) consumption during pregnancy and lactation affects lipid metabolism of offspring in later life. The purpose of this study was to elucidate the effect of maternal fat intake on metabolic alteration of intestine as well as liver in male and female adult mice offspring. Female mice were fed either standard chow (C) or HFD (H). Offspring were fed a chow diet until eleven weeks, then challenged with either C or H diet, and divided into eight groups in accordance with mother's and offspring’s diets: male(M) CC, MHC, MCH, MHH, female(F) CC, FHC, FCH, and FHH. Hepatic expression of Oatp1a1 and Oatp1b2 was increased in MHH, compared to MCH. Hepatic expression of HMGCoAR, Cyp7a1, Sult2a1, and Oatp1a4 was increased in FHH, compared to FCH. On the other hand, intestinal mRNA expression of adult offspring was not affected by the maternal HFD.
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