| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Indoxyl sulfate (IS) as uremic toxins, is accumulated in the serum to CKD patients. However, the relationship to between rise in serum FGF23 and IS has not been elucidated. The present study was undertaken to examine the effects of IS on FGF23 production in rat osteosarcoma UMR-106 cells. We obtained following findings: (1) The up-regulation of GalNAc-T3 by IS suppress proteolytic processing of FGF23 and probably stimulates the elevation of serum FGF23; (2) We investigated effect of an ethanol-extract from several vegetables on the FGF23 production in UMR106 cells. As a result, the production of FGF23 by IS was inhibited by addition of the ethanol extracts from Broccoli sprout (Brassica oleracea var. italica) and mulukhiya (Corchorus olitorius). Our finding could contributes to develop the FGF23-targeting the development of diet therapy for CKD.
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