| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We examined the direct effects of polyphenols on the contractile response of mouse aortas and whether they are mediated by the endothelium-dependent mechanism. The polyphenols induced dose-dependent relaxation in the aortas precontracted with phenylephrine. The effects were dependent on endothelial nitric oxide (NO) and calcium-activated or voltage-dependent potassium channels as well. Additionally, the polyphenols enhanced acetylcholine-induced relaxation, which was also dependent on the potassium channels. The vasorelaxant effects of the polyphenols observed in this study lend pharmacological support to epidemiological studies, which postulate an inverse association between dietary polyphenol consumption and vascular complications in the related metabolic disorders.
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