Studies on the molecular mechanisms of effects of polyphenols on risk factors for glucose and lipid metabolic disorders aiming for the prevention of the metabolic syndrome
| Project/Area Number |
15K00865
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Shokei University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 機能性食品成分 / ポリフェノール / 代謝異常症 |
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| Outline of Final Research Achievements |
We examined the direct effects of polyphenols on the contractile response of mouse aortas and whether they are mediated by the endothelium-dependent mechanism. The polyphenols induced dose-dependent relaxation in the aortas precontracted with phenylephrine. The effects were dependent on endothelial nitric oxide (NO) and calcium-activated or voltage-dependent potassium channels as well. Additionally, the polyphenols enhanced acetylcholine-induced relaxation, which was also dependent on the potassium channels. The vasorelaxant effects of the polyphenols observed in this study lend pharmacological support to epidemiological studies, which postulate an inverse association between dietary polyphenol consumption and vascular complications in the related metabolic disorders.
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Report
(4 results)
Research Products
(4 results)
