Suppressive effects of dietary antioxidants on inflammation of visceral adipose tissues in diet-induced obese mice

• Project/Area Number: 15K00867
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: KOBORI Masuko 国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, ユニット長 (50353941)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: クルクミン / ケルセチン / 内臓脂肪組織 / 慢性炎症 / 肥満 / 免疫 / β-クリプトキサンチン

Outline of Final Research Achievements

Inflammation of visceral adipose tissue is known to cause insulin resistance and metabolic syndrome. We examined the effects of dietary antioxidants on inflammation of visceral adipose tissue of diet-induced obese mice. Although the carotenoid β-cryptoxanthin scarcely suppressed the inflammation of epidydimal adipose tissue in diet-induced obese mice, curcumin suppressed the oxidative stress and inflammation on the tissue. We compared genes that were considerably up- or downregulated by curcumin with those altered by anti-oxidative flavonoid quercetin in epidydimal adipose tissue of obese mice. The results illustrated that curcumin suppressed the oxidative stress, ER stress and lipogenesis in the tissue. Quercetin was more effective in inhibiting the inflammation of the epidydimal adipose tissue. Quercetin was suggested to improve the inflammation through improving the lipid metabolism in the liver and reducing the fat accumulation in the tissue.

Research Products

• [Journal Article] Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet-induced obese mice. (2016)
  • Author(s): Masuko Kobori, Yumiko Takahashi, Mutsumi Sakurai, Yukari Akimoto, Tojiro Tsushida, Hideaki Oike, Katsunori Ippoushi
  • Journal Title: Molecular Nutrition & Food Research Volume: 60 Issue: 2 Pages: 300-312
  • DOI: 10.1002/mnfr.201500595
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] クルクミンが食餌性肥満モデルマウスの精巣上体脂肪組織に及ぼす影響 (2017)
  • Author(s): 小堀 真珠子,高橋 弓子,秋元 由香里,桜井 睦,大池 秀明,木村 俊之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] Curcumin alters gene expression and lipid profiles in visceral adipose tissue of diet-induced obese mice (2017)
  • Author(s): Masuko Kobori, Yumiko Takahashi, Hiroaki Takeda, Masatomo Takahashi, Yukari Akimoto, Mutsumi Sakurai, Hideaki Oike, Yoshihiro Izumi, Takeshi Bamba, Toshiyuki Kimura
  • Organizer: 46th Annual Meeting of Food and Agriculture Panel,US-Japan Cooperative Program in Natural Resources
  • Int'l Joint Research
• [Presentation] Effect of the antioxidant curcumin on transcriptome and lipid profiles in visceral adipose tissues of diet-induced obese mice. (2017)
  • Author(s): Masuko Kobori, Yumiko Takahashi, Hiroaki Takeda, Masatomo Takahashi, Yukari Akimoto, Mutsumi Sakurai, Hideaki Oike, Yoshihiro Izumi, Takeshi Bamba, Toshiyuki Kimura
  • Organizer: ISNFF2017 The International Conference and Exhibition on Nutraceutical & Functional Foods
  • Int'l Joint Research / Invited
• [Presentation] ffects of curcumin and quercetin on diet-induced obesity and metabolic syndrome in mice. (2016)
  • Author(s): Masuko Kobori
  • Organizer: 45th United States-Japan Cooperative Program in. Natural Resources (UJNR) Food and Agriculture Panel Meeting.
  • Place of Presentation: ホノルル（アメリカ）
  • Year and Date: 2016-11-07
  • Int'l Joint Research
• [Presentation] Dietary Quercetin Suppresses inflammation of Visceral Adipose Tissue and Improves Metabolic Syndrome in Diet-induced Obese Mice. (2016)
  • Author(s): Masuko Kobori
  • Organizer: 7th Annual Conference American Council for Medicinally Active Plants.
  • Place of Presentation: リマ（ペルー）
  • Year and Date: 2016-06-29
  • Int'l Joint Research / Invited
• [Presentation] ケルセチンの摂取は食餌性肥満モデルにおける精巣上体脂肪組織の炎症を抑制する (2016)
  • Author(s): 小堀真珠子、高橋弓子、桜井睦、秋元由香里、大池秀明、一法師克成
  • Organizer: 日本農芸化学会2016年度大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-27
• [Presentation] Quercetin suppresses the accumulation of immune cells in epididymal adipose tissues of diet-induced obese mice (2015)
  • Author(s): Masuko Kobori
  • Organizer: International Conference on Food Factors (ICoFF2015)
  • Place of Presentation: ソウル（韓国）
  • Year and Date: 2015-11-22
  • Int'l Joint Research / Invited