| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Inflammation of visceral adipose tissue is known to cause insulin resistance and metabolic syndrome. We examined the effects of dietary antioxidants on inflammation of visceral adipose tissue of diet-induced obese mice. Although the carotenoid β-cryptoxanthin scarcely suppressed the inflammation of epidydimal adipose tissue in diet-induced obese mice, curcumin suppressed the oxidative stress and inflammation on the tissue. We compared genes that were considerably up- or downregulated by curcumin with those altered by anti-oxidative flavonoid quercetin in epidydimal adipose tissue of obese mice. The results illustrated that curcumin suppressed the oxidative stress, ER stress and lipogenesis in the tissue. Quercetin was more effective in inhibiting the inflammation of the epidydimal adipose tissue. Quercetin was suggested to improve the inflammation through improving the lipid metabolism in the liver and reducing the fat accumulation in the tissue.
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